Acetate consuming yeast cell

A yeast cell that is genetically modified comprising:

• a) a disruption of one or more nucleotide sequence encoding an aldehyde dehydrogenase-6 (ALD6) (E.C. 1.2.1.4) native to the yeast;
• b) one or more nucleotide sequence encoding a heterologous NAD+-dependent acetylating acetaldehyde dehydrogenase (E.C. 1.2.1.10);
• c) one or more nucleotide sequence encoding a homologous or heterologous acetyl-CoA synthetase (E.C. 6.2.1.1);
• and
• d) a disruption or mutation in one or more endogenous gene encoding glycerol 3-phosphate phosphohydrolase (E.C. 3.1.3.21) and/or glycerol 3-phosphate dehydrogenase (E.C. 1.1.1.8 or E.C. 1.1.5.3), whereby said disruption or mutation reduces the amount of glycerol 3-phosphate phosphohydrolase and/or glycerol 3-phosphate dehydrogenase activity;
• e) one or more nucleotide sequence encoding a heterologous glycerol dehydrogenase (E.C. 1.1.1.6);
• f) one or more nucleotide sequence encoding a homologous or heterologous dihydroxyacetone kinase (E.C. 2.7.1.28 or E.C. 2.7.1.29);
• and
• wherein the yeast cell is a pentose and glucose fermenting yeast cell that is capable of anaerobic simultaneous pentose and glucose consumption.