Compound used as autophagy regulator, and preparation method therefor and uses thereof

A compound of general formula (IVd), or pharmaceutically acceptable salts thereof:

• wherein:
• R1 is selected from the group consisting of H deuterium, and C1-6 hydroxyalkyl;
• R3 is selected from the group consisting of
• wherein, Rc, Rc1, Rc2, Rc′ and Rc″ are each independently selected from the group consisting of H, hydroxyl, amino group, NRaRa′, halogen, cyano, nitro, carboxyl, formyl, amide group, ester group, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 alkoxy, C1-6 alkoxyalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, 3-10 membered heterocycloalkyl, 3-7 membered heterocycloalkenyl, C1-6 alkyl C6-10 aryl, 5-10 membered heteroaryl C1-6 alkyl or C1-6 alkyl 5-10 membered heteroaryl;
• and
• Ra and Ra′ are each independently H or C1-6 alkyl;
• or
• R3 is
• Rc is -hydroxyl, amino group, NRaRa′, halogen, cyano, nitro, carboxyl, formyl, amide group, ester group, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 alkoxy, C1-6 alkoxyalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, 3-10 membered heterocycloalkyl, 3-7 membered heterocycloalkenyl, C1-6 alkyl C6-10 aryl, 5-10 membered heteroaryl C1-6 alkyl, or C1-6 alkyl 5-10 membered heteroaryl, and Ra and Ra′ are each independently H or C1-6 alkyl;
• or
• R3 is selected from the following groups:
• wherein, X1 is F, Cl, Br, I or trifluoromethyl;
• X2 is H, F, Cl, Br, or I;
• Rc1, Rc2, Rc3, or Rc4 is each independently selected from the group consisting of H, hydroxyl, amino group, NRaRa′, halogen, cyano, nitro, carboxyl, formyl, amide group, ester group, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 alkoxy, C1-6 alkoxyalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, 3-10 membered heterocycloalkyl, 3-7 membered heterocycloalkenyl, C1-6 alkyl C6-10 aryl, 5-10 membered heteroaryl C1-6 alkyl or C1-6 alkyl 5-10 membered heteroaryl;
• and
• Ra and Ra′ are each independently H or C1-6 alkyl;
• and
• R4 is H;
• unsubstituted or substituted means that the group is unsubstituted or substituted by one or more substituents selected from the group consisting of hydroxyl, amino group, cyano, nitro, carboxyl, halogen, C1-6 alkyl, C1-6 haloalkyl or C1-6 hydroxyalkyl, or two adjacent substituents may be bonded to form a C6-10 aryl group, a C5-10 heteroaryl group, a C3-10 cycloalkyl group or a C3-10 heterocycloalkyl group.