Pharmaceutical active-containing film delivery device for oral transmucosal administration

A single layer transmucosal delivery device comprising:

• a polymer film comprising a polymer matrix, and
• a pharmaceutical composition comprising a taste masking agent and nalmefene or a salt thereof, wherein the composition is disposed on a surface of the polymer film in the form of a non-self-supporting domain, and wherein the pharmaceutical composition has a concentration of nalmefene such that upon administration of the composition to a subject, the subject has a mean plasma concentration of nalmefene of at least 1 ng/ml, within 30 minutes after administration,
• wherein the delivery device exhibits a residence time in the mouth of a subject ranging from about 5 minutes to about 15 minutes and is substantially mucoadhesive to a mucosal surface when placed sublingually under the tongue or placed buccally at the inner lining of the cheek of the subject.

A single layer transmucosal delivery device comprising:

• a polymer film comprising a polymer matrix, and
• a pharmaceutical composition disposed directly on a surface of the polymer film, the composition comprising one pharmaceutical active, wherein the one pharmaceutical active is nalmefene or a salt thereof.