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US 11,312,986 B2Granted
Biosynthesis of everninomicin analogs in Micromonospora carbonacea var aurantiaca
AssigneeVanderbilt University
InventorsBrian O. Bachmann, Emilianne M. Limbrick, Kasia Derewacz
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Abstract
Disclosed are methods of preparing everninomicin analogs by genetic alteration of Micromonospora carbonacea. Everninomicin analogs prepared by these methods and methods of using these analogs to treat infections are also disclose.
Claims8
A compound having the structure:
- wherein
- R3 is H or CH3;
- R5 is H, OH, or OCH3;
- R6 is H, or substituted C1-C6 alkyl;
- R7 is H, or substituted C1-C6 alkyl;
- R8 is substituted C1-C6 alkyl;
- and
- R11 is H, NH2, NO2, NOH, or C1-C6 alkyl, optionally substituted with alkyl, alkoxy, alkenyl, amino, azido, carboxylic acid, cyano, halide, hydroxy, nitro, or a 1-20 atom linker bound to rosaramicin;
- or a pharmaceutically acceptable salt thereof.
6 more elements
A compound having the structure:
- wherein
- R3 is H or CH3;
- R5 is H, OH, or OCH3;
- R6 is H or substituted C1-C6 alkyl;
- R7 is H or substituted C1-C6 alkyl;
- R8 is substituted C1-C6 alkyl;
- and
- R11 is H, NH2, NO2, NOH, or C1-C6 alkyl, optionally substituted with alkyl, alkoxy, amino, azido, carboxylic acid, cyano, halide, hydroxy, nitro, or a 1-20 atom linker bound to rosaramicin;
- or a pharmaceutically acceptable salt thereof.
6 more elements
A compound having the structure:
- wherein R1 and R5 are each, individually, H, OH, or OCH3;
- R2 is H or Cl;
- R6 is H, or substituted C1-C6 alkyl;
- R7 is H, or substituted C1-C6 alkyl;
- and
- R8 is substituted C1-C6 alkyl;
- and
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.