Nucleic acid for treating mite allergy
AssigneeAstellas Pharma Inc.
InventorsTakanori Marui, Masao Uchida
Life of this patent
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Abstract
[Problem] To provide a nucleic acid expected to be useful for treating mite allergy. [Means to be solved] Provided is a nucleic acid comprising a nucleotide sequence encoding a chimeric protein, wherein the nucleic acid comprises a nucleotide sequence encoding a signal peptide, a nucleotide sequence encoding an intra-organelle stabilizing domain of LAMP, a nucleotide sequence encoding an allergen domain comprising Der p 1, Der p 2, Der p 23, and Der p 7, a nucleotide sequence encoding a transmembrane domain and a nucleotide sequence encoding an endosomal/lysosomal targeting domain of LAMP in this order.
Claims12
A nucleic acid encoding a chimeric protein, wherein the nucleic acid comprises the following nucleotide sequences in this order:
- a nucleotide sequence encoding a signal peptide;
- a nucleotide sequence encoding an intra-organelle stabilizing domain of lysosome-associated membrane proteins (LAMP) consisting of amino acids 28 to 380 of SEQ ID NO:
- 2;
- a nucleotide sequence encoding an allergen domain consisting of amino acids 383 to 1002 of SEQ ID NO:
- 2;
- a nucleotide sequence encoding a transmembrane domain of LAMP-1 consisting of amino acids 1006 to 1028 of SEQ ID NO:
- 2;
- and
- a nucleotide sequence encoding an endosomal/lysosomal targeting domain of LAMP-1 consisting of amino acids 1037 to 1040 of SEQ ID NO:
- 2.
A nucleic acid encoding a chimeric protein consisting of an amino acid sequence having at least 90% identity to SEQ ID NO:
- 2.
A nucleic acid comprising:
- a) a nucleotide sequence encoding a chimeric protein consisting of the nucleic acid sequence of SEQ ID NO:
- 2;
- or
- b) a nucleotide sequence encoding a chimeric protein consisting of an amino acid sequence of SEQ ID NO:
- 2 in which 1 to 10 amino acids are deleted, substituted, inserted and/or added.
A nucleic acid comprising:
- a nucleotide sequence encoding a chimeric protein consisting of the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.