Molecular host frameworks and methods of making and using same
AssigneeNew York University
InventorsMichael David Ward, Yuantao Li, Chunhua Tony Hu
Life of this patent
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Abstract
Crystalline molecular framework:small molecule compounds. The molecular framework is formed from guanidinium cations and organosulfonate anions and the guanidinium cations and organosulfonate anions are associated via one or more hydrogen bond. The small molecule(s) is/are encapsulated by the molecular framework. Methods for making crystalline molecular framework:small molecule compounds may include combining guanidinium cations, organosulfonate anions, and small molecules in a single step. The crystalline molecular framework:small molecule compounds can be used to determine the structure of the small molecule(s).
Claims18
A method of determining the structure of a small molecule comprising:
- subjecting a crystalline molecular framework:small molecule compound to structure determination by X-ray analysis, wherein the structure of one or more or all of the small molecule(s) and, optionally, the molecular framework and/or the crystalline molecular:small molecule compound is determined,
- wherein the crystalline molecular framework:small molecule compound comprises a molecular framework and one or more small molecules,
- the molecular framework comprises a plurality of guanidinium cations and a plurality of organosulfonate anions,
- the guanidinium cations and organosulfonate anions are associated via one or more hydrogen bond and the small molecule(s) is/are encapsulated by the molecular framework, and
- at least one small molecule or all of the small molecules has/have one or more stereocenters and the relative stereochemistry and the absolute configuration of one or more of the stereogenic centers in the small molecule(s) is/are determined.
Dependencies are inferred from the claim text.