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US 11,312,676 B2Granted
Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer
AssigneeBaylor College of Medicine
InventorsDavid Michael Lonard, Lei Wang, Bert W. O'Malley, Jianming Xu, Yongcheng Song, Xiaonan Li, Timothy Gerald Palzkill
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Abstract
Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.
Claims7
A method for treating cancer in a subject, comprising:
- administering to the subject an effective amount of a compound of the following formula:
- or a pharmaceutically acceptable salt or prodrug thereof, wherein:
- A1, A2, A6, and A7 are each independently CR1, wherein each R1 is hydrogen, halogen, alkoxy, cyano, trifluoromethyl, or substituted or unsubstituted C1-6 alkyl;
- A3, A4, A5, A8, A9, and A10 are each CH;
- and
- X is NR4, wherein R4 is substituted or unsubstituted C3-6 alkyl
- wherein the cancer is selected from the group consisting of breast cancer, liver cancer, lung cancer, prostate cancer, and glioblastoma.
4 more elements
Dependencies are inferred from the claim text.