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US 11,311,483 B2Granted
Curcumin solubilisate
AssigneeAquanova AG
InventorDariush Behnam
Life of this patent
Estimating the term…
Abstract
A solubilisate consisting of curcumin in a quantity of less than or equal to 10% by weight, preferably less than or equal to 7.5% by weight, particularly preferably 6% by weight, and at least one emulsifier having an HLB value in the range between 13 and 18, in particular polysorbate 80 or polysorbate 20 or a mixture of polysorbate 20 and polysorbate 80, wherein the average diameter of the micelles loaded with curcumin is between 5 nm and 40 nm, preferably between 6 nm and 20 nm, particularly preferably between 7 nm and 10 nm.
Claims6
A transparent, water-soluble liquid curcumin formulation prepared by a process comprising:
- (a) heating polysorbate 80 to a temperature of about 48° C. to about 52° C.,
- (b) adding curcumin to the polysorbate 80 with stirring and heating the resulting mixture to a temperature of about 87° C. to about 91° C.;
- and
- (c) cooling the resulting formulation of step (b) to about 60° C.,
- wherein the water-soluble liquid curcumin formulation consists of:
- curcumin in a quantity of more than 6% by weight to less than or equal to 7.5% by weight;
- and
- polysorbate 80,
- wherein upon dilution of the transparent, water-soluble liquid curcumin formulation, micelles of curcumin and the polysorbate 80 can be detected,
- wherein the average diameter of the micelles is between 5 nm and 40 nm in a 1:1000 aqueous dilution of the transparent, water-soluble liquid curcumin formulation,
- wherein the width of the diameter distribution of the micelles ranges from approximately 4 nm to approximately 30 nm, and
- wherein the turbidity of a 1:1000 aqueous dilution of the transparent, water-soluble liquid curcumin formulation is less than 20 FNU, determined by scattered light measurement with infrared light according to the requirements of the ISO 7027 standard, measured after 1 hour storage under one or more of the following conditions:
- 37° C. and pH 1.1, and
- 37° C. and pH 7.
11 more elements
Dependencies are inferred from the claim text.