# US 11,309,846 B2 · Cascode common source transimpedance amplifiers for analyte monitoring systems > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,309,846 B2 - Document ID: US11309846B2 - Status: Granted - Kind: B2 - Application number: 16/008,864 - Filed: 2018-06-14 - Published: 2019-04-25 - Granted: 2022-04-19 - Earliest claimed: 2017-08-25 - Assignees: University of South Florida - Applicants: University of South Florida - Inventors: Kavyashree Puttananjegowda; Sylvia Thomas - Web page: https://patentgrep.com/patent/US11309846B2 ## CPC - H03F 1/223: {with MOSFET's} - B01L 3/5023: {with a sample being transported to, and subsequently stored in an absorbent for analysis} - G01N 27/327: Biochemical electrodes {, e.g. electrical or mechanical details for in vitro measurements} - G01N 33/49: Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} - H03F 3/16: with field-effect devices - H03F 3/345: with field-effect devices (H03F3/347 takes precedence) - H10K 19/10: comprising field-effect transistors - B01L 2300/023: Sending and receiving of information, e.g. using Bluetooth® - B01L 2300/0636: Integrated biosensor, microarrays - B01L 2300/0825: Test strips - H03F 2200/129: there being a feedback over the complete amplifier - H03F 2200/144: the feedback circuit of the amplifier stage comprising a passive resistor and passive capacitor - H03F 2200/294: the amplifier being a low noise amplifier [LNA] - H10K 10/464: {Lateral top-gate IGFETs comprising only a single gate} - H10K 85/221: {Carbon nanotubes} - H03F: AMPLIFIERS - B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - H10K: ORGANIC ELECTRIC SOLID-STATE DEVICES ## Abstract A biosensor for an analyte monitoring system. In one embodiment, the biosensor includes a cascode common source transimpedance amplifier circuit, an analog to digital converter, and an output circuit. The cascode common source transimpedance amplifier circuit is configured to receive an electrical current generated by an electrochemical reaction of an analyte on a test strip. The cascode common source transimpedance amplifier circuit is also configured to convert the electrical current to an analog voltage signal. The analog to digital converter is configured to convert the analog voltage signal to a digital voltage signal. The output circuit is configured to transmit a signal indicating a measured level of the analyte based on the digital voltage signal. ## Claims ### Claim 1 A biosensor comprising: a cascode common source transimpedance amplifier circuit comprising: an input terminal for receiving an electrical current generated by an electrochemical reaction of an analyte on a test strip; and a first stage having a first n-type channel metal oxide semiconductor (NMOS) transistor having a gate electrode connected to the input terminal; a second NMOS transistor cascode connected to the first NMOS transistor; a first p-type channel metal oxide semiconductor (PMOS) transistor connected to the second NMOS transistor, a second PMOS transistor cascode connected to the first PMOS transistor, a second stage having a third NMOS transistor connected to an output of the first stage, and a fourth NMOS transistor cascode connected to the third NMOS transistor, and an output terminal connected to an output of the second stage, the output terminal being directly connected to the third NMOS transistor and the fourth NMOS transistor the cascode common source transimpedance amplifier circuit configured to convert the electrical current to an analog voltage signal; an analog to digital converter configured to convert the analog voltage signal to a digital voltage signal; and an output circuit configured to transmit a signal indicating a measured level of the analyte based on the digital voltage signal. ### Claim 2 (depends on 1) The biosensor of claim 1, wherein the cascode common source transimpedance amplifier circuit further includes a resistor connected in series between the output terminal and the input terminal, and a capacitor connected in series between the output terminal and the input terminal. ### Claim 3 (depends on 1) The biosensor of claim 1, wherein a transimpedance gain of the cascode common source transimpedance amplifier circuit is 1.72 gigaohms at a bandwidth of 180 kilohertz. ### Claim 4 (depends on 1) The biosensor of claim 1, wherein the cascode common source transimpedance amplifier circuit is connected to a power supply voltage source of 1.4 volts. ### Claim 5 (depends on 4) The biosensor of claim 4, the cascode common source transimpedance amplifier circuit is configured to consume 45.7 microwatts of power from the power supply voltage source. ### Claim 6 (depends on 1) The biosensor of claim 1, wherein the first stage further comprises: a source electrode of the first NMOS transistor that is connected to a reference voltage terminal; a source electrode of the second NMOS transistor that is connected to a drain electrode of the first NMOS transistor; wherein a drain electrode of the first PMOS transistor is connected to a drain electrode of the second NMOS transistor, wherein a source electrode of the second PMOS transistor is connected to a power supply voltage source terminal, wherein a drain electrode of the second PMOS transistor is connected to a source electrode of the first PMOS transistor, the second stage further comprising: a gate electrode of the third NMOS transistor connected to the drain electrode of the second NMOS transistor and to the drain electrode of the first PMOS transistor, wherein a drain electrode of the third NMOS transistor is connected to the power supply voltage source terminal, and a drain electrode of the fourth NMOS transistor connected to a source electrode of the third NMOS transistor, wherein a source electrode of the fourth NMOS transistor is connected to the reference voltage terminal, and wherein the output terminal is connected to the source electrode of the third NMOS transistor and to the drain electrode of the fourth NMOS transistor. ### Claim 7 (depends on 6) The biosensor of claim 6, wherein the cascode common source transimpedance amplifier circuit further includes a resistor connected in series between the output terminal and the input terminal, and a capacitor connected in series between the output terminal and the input terminal. ### Claim 8 (depends on 1) The biosensor of claim 1, wherein the output circuit provides a low frequency. ### Claim 9 (depends on 1) The biosensor of claim 1, wherein the output circuit provides a frequency in a range of 1 hertz to 50 kilohertz. ### Claim 10 (depends on 1) The biosensor of claim 1, further comprising a biasing circuit that comprises a n-type transistor and a p-type transistor, the n-type transistor configured to generate a first biasing voltage for a n-type transistor of a first stage cascode amplifier of a cascode common source transimpedance amplifier circuit, the p-type transistor configured to generate a second biasing voltage for a p-type transistor of the first stage cascode amplifier. ### Claim 11 (depends on 1) The biosensor of claim 1, wherein the analyte is blood glucose. ### Claim 12 A biosensor, comprising: a cascode common source transimpedance amplifier circuit including an input terminal for receiving an electrical current generated by an electrochemical reaction of an analyte on a test strip; and a first stage having a first n-type channel carbon nanotube field effect transistor (NCNTFET) having a gate electrode coupled to the input terminal, a second NCNTFET cascode connected to the first NCNTFET, a first p-type channel carbon nanotube field effect transistor (PCNTFET) connected to the second NCNTFET, a second PCNTFET cascode connected to the first PCNTFET, a second stage having a third NCNTFET connected to an output of the first stage, and a fourth NCNTFET cascode connected to the third NCNTFET, an output terminal connected to an output of the second stage, the output terminal being directly connected to the third NCNTFET and the fourth NCNTFET; the cascode common source transimpedance amplifier circuit configured to convert the electrical current to an analog voltage signal; an analog to digital converter configured to convert the analog voltage signal to a digital voltage signal; and an output circuit configured to transmit a signal indicating a measured level of the analyte based on the digital voltage signal. ### Claim 13 (depends on 12) The biosensor of claim 12, wherein a transimpedance gain of the cascode common source transimpedance amplifier circuit is 5.7 gigaohms at a bandwidth of 200 megahertz. ### Claim 14 (depends on 12) The biosensor of claim 12, wherein the cascode common source transimpedance amplifier circuit is connected to a power supply voltage source of 1.8 volts. ### Claim 15 (depends on 14) The biosensor of claim 14, wherein the cascode common source transimpedance amplifier circuit is configured to consume 6.3 picowatts of power from the power supply voltage source. ### Claim 16 (depends on 12) The biosensor of claim 12, wherein a source electrode of the first NCNTFET is connected to a reference voltage terminal, wherein a drain electrode of the first NCNTFET is connected to a source electrode of the second NCNTFET, wherein a drain electrode of the second NCNTFET is connected to a drain electrode of the first PCNTFET, wherein a source electrode of the first PCNTFET is connected to a drain electrode of the second PCNTFET, wherein a source electrode of the second PCNTFET is connected to a power supply voltage source terminal, wherein a gate electrode of the third NCNTFET is connected to the drain electrode of the second NCNTFET and to the drain electrode of the first PCNTFET, wherein a drain electrode of the third NCNTFET is connected to the power supply voltage source terminal, wherein a source electrode of the third NCNTFET is connected to a drain electrode of the fourth NCNTFET, wherein a source electrode of the fourth NCNTFET is connected to the reference voltage terminal, and wherein the output terminal is connected to the source electrode of the third NCNTFET and to the drain electrode of the fourth NCNTFET. ### Claim 17 (depends on 12) The biosensor of claim 12, wherein the cascode common source transimpedance amplifier circuit a resistor connected in series between the output terminal and the input terminal, and a capacitor connected in series between the output terminal and the input terminal.