# US 11,309,171 B2 · Analytical device, analytical method and program

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- Number: US 11,309,171 B2
- Document ID: US11309171B2
- Status: Granted
- Kind: B2
- Application number: 17/053,106
- Filed: 2018-05-07
- Published: 2021-03-04
- Granted: 2022-04-19
- Earliest claimed: 2018-05-07
- Assignees: Shimadzu Corporation
- Applicants: Shimadzu Corporation
- Inventors: Manabu Shimomura
- Web page: https://patentgrep.com/patent/US11309171B2

## CPC

- H01J 49/0027: {Methods for using particle spectrometers}
- H01J 49/0422: {for gaseous samples (interfaces to gas chromatographs G01N30/7206)}
- G01N 27/62: by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N 30/72: Mass spectrometers {(mass spectrometers per se H01J49/00)}
- H01J 49/4265: {Controlling the number of trapped ions; preventing space charge effects}
- H01J 49/4295: {Storage methods}
- H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

An analytical device, includes: an ionization unit that ionizes carrier gas introduced into the separation column; a mass separation unit that mass-separates ions generated in the ionization unit; a detection unit that detects the ions mass-separated by the mass separation unit in amplification with a predetermined multiplication factor, and outputs a detection signal; an analysis unit that analyzes the detection signal having been output from the detection unit; and an adjustment unit performs an adjustment of the multiplication factor of the detection unit and/or voltage applied to an electrode of an ion transport system of the mass separation unit based on magnitude of the detection signal corresponding to the carrier gas detected by the detection unit.

## Claims

### Claim 1

An analytical device, comprising:
an ionization unit that ionizes carrier gas introduced into a separation column;
a mass separation unit that mass-separates ions generated in the ionization unit;
a detection unit that detects the ions having been mass-separated by the mass separation unit in amplification with a predetermined multiplication factor, and outputs a detection signal;
an analysis unit that analyzes the detection signal having been output from the detection unit;
a flow rate measurement unit that measures a flow rate of the carrier gas; and
an adjustment unit that performs an adjustment of the multiplication factor of the detection unit and/or voltage applied to an electrode of an ion transport system of the mass separation unit based on the flow rate of the carrier gas having been measured and magnitude of the detection signal corresponding to the carrier gas detected by the detection unit.

### Claim 2 (depends on 1)

The analytical device according to claim 1, wherein:
the ion transport system is at least one selected from the group consisting of a lens electrode, an ion guide, and a quadrupole mass filter.

### Claim 3

An analytical method, comprising:
performing of an ionization of carrier gas introduced into a separation column;
performing of a mass-separation of ions generated by ionization;
performing of a detection of the ions having been mass-separated by amplification with a predetermined multiplication factor, and of an output of a detection signal by a detection unit;
performing of an analysis of the detection signal having been output;
performing of a measurement of a flow rate of the carrier gas; and
performing of an adjustment of the multiplication factor of the detection unit, and/or of a voltage applied to an electrode of an ion transport system in the mass-separation based on the flow rate of the carrier gas having been measured and magnitude of the detection signal corresponding to the carrier gas detected by the detection unit.

### Claim 4 (depends on 3)

The analytical method according to claim 3, wherein:
the ion transport system is at least one selected from the group consisting of a lens electrode, an ion guide, and a quadrupole mass filter.

### Claim 5

A non-transitory computer-readable medium including a program for a processing device of an analytical device, the analytical device performing:
an ionization of carrier gas introduced into a separation column;
a mass-separation of ions generated by ionization;
a detection of the ions having been mass-separated in amplification with a predetermined multiplication factor by a detection unit;
an output of a detection signal by the detection unit;
an analysis of the detection signal having been output; and
a measurement of a flow rate of the carrier gas, wherein:
the program causes the processing device to perform an adjustment of the multiplication factor of the detection unit and/or of a voltage applied to an electrode of an ion transport system in the mass-separation based on the flow rate of the carrier gas having been measured and magnitude of the detection signal corresponding to the carrier gas detected by the detection unit.