# US 11,309,170 B2 · Methods for testing or adjusting a charged-particle detector, and related detection systems > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,309,170 B2 - Document ID: US11309170B2 - Status: Granted - Kind: B2 - Application number: 16/856,085 - Filed: 2020-04-23 - Published: 2020-11-12 - Granted: 2022-04-19 - Earliest claimed: 2018-02-13 - Assignees: Biomerieux - Applicants: bioMerieux, Inc. - Inventors: James Arthur VanGordon - Web page: https://patentgrep.com/patent/US11309170B2 ## CPC - H01J 49/0009: {Calibration of the apparatus} - H01J 49/025: {Detectors specially adapted to particle spectrometers (data acquisition H01J49/0036; detectors per se G01T, e.g. G01T1/28, G01T1/29)} - H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H) ## Abstract Methods for testing or adjusting a charged-particle detector are provided. A diagnostic and/or adjustment method for a charged-particle detector of an instrument includes providing, from a photon source, photons incident on the charged-particle detector. Moreover, the method includes detecting a response by the charged-particle detector to the photons incident thereon. Related detection systems are also provided. ## Claims ### Claim 1 A method for a charged-particle detector of a mass spectrometer, the method comprising: receiving photons at the charged-particle detector; detecting a response by the charged-particle detector that is independent of any ionizing event in the mass spectrometer; measuring a signal gain of the charged-particle detector; and comparing the signal gain of the charged-particle detector with a predetermined value or with a measured signal gain of another charged-particle detector, in response to an output signal of the charged-particle detector. ### Claim 2 (depends on 1) The method of claim 1, wherein the charged-particle detector comprises an ion detector, and wherein the detecting comprises determining whether the ion detector provides the output signal. ### Claim 3 (depends on 2) The method of claim 2, wherein determining whether the ion detector provides the output signal comprises determining whether the output signal of the ion detector pulses during pulsing of the photons. ### Claim 4 (depends on 2) The method of claim 2, further comprising: adjusting the signal gain of the ion detector, in response to determining that the signal gain of the ion detector does not match the predetermined value and/or does not match the measured signal gain of the another ion detector. ### Claim 5 (depends on 2) The method of claim 2, further comprising: removing one or more portions of an ion optics system from a housing of the mass spectrometer that includes a flight tube that is in communication with the ion detector, wherein the detecting is performed while the one or more portions of the ion optics system is removed. ### Claim 6 A mass spectrometer comprising: a housing enclosing an analysis flow path; a charged-particle detector; a light source configured to provide light inside the housing to generate ions incident on the charged-particle detector; and a pulsing photon source configured to provide pulses to the charged-particle detector, wherein the mass spectrometer is configured to detect a pulsed response by the charged-particle detector that is independent of any ionizing event in the mass spectrometer. ### Claim 7 (depends on 6) The mass spectrometer of claim 6, further comprising a flight tube in the housing and defining a free drift portion of the analysis flow path, wherein the charged-particle detector is in communication with the flight tube and comprises a Micro-Channel Plate (MCP). ### Claim 8 (depends on 7) The mass spectrometer of claim 7, wherein the flight tube comprises first and second cylinders. ### Claim 9 (depends on 6) The mass spectrometer of claim 6, wherein the light source comprises a laser. ### Claim 10 (depends on 6) The mass spectrometer of claim 6, further comprising an ion optics system through which the ions are configured to pass toward the charged-particle detector. ### Claim 11 A mass spectrometer comprising: a housing enclosing an analysis flow path; a charged-particle detector that is configured to receive photons; a light source configured to provide light inside the housing to generate ions incident on the charged-particle detector; and a processor that is configured to detect a response by the charged-particle detector that is independent of any ionizing event in the mass spectrometer, wherein the processor is further configured to: measure a signal gain of the charged-particle detector; and compare the signal gain of the charged-particle detector with a predetermined value or with a measured signal gain of another charged-particle detector, in response to an output signal of the charged-particle detector. ### Claim 12 (depends on 11) The mass spectrometer of claim 11, further comprising a flight tube in the housing and defining a free drill portion of the analysis flow path, wherein the charged-particle detector is in communication with the flight tube and comprises a Micro-Channel Plate (MCP). ### Claim 13 (depends on 12) The mass spectrometer of claim 12, wherein the flight tube comprises first and second cylinders. ### Claim 14 (depends on 11) The mass spectrometer of claim 11, wherein the light source comprises a laser. ### Claim 15 (depends on 11) The mass spectrometer of claim 11, further comprising an ion optics system through which the ions are configured to pass toward the charged-particle detector. ### Claim 16 (depends on 11) The mass spectrometer of claim 11, wherein the processor is configured to detect the response by determining whether the charged-particle detector provides the output signal. ### Claim 17 (depends on 11) The mass spectrometer of claim 11, wherein the processor is further configured to: adjust the signal gain of the charged-particle detector, in response to determining that the signal gain of the charged-particle detector does not match the predetermined value and/or does not match the measured signal gain of the another charged-particle detector. ### Claim 18 (depends on 11) The mass spectrometer of claim 11, further comprising: an ion optics system that includes a flight tube that is in communication with the charged-particle detector, wherein the processor is configured to detect the response while one or more portions of the ion optics system is removed from the housing. ### Claim 19 (depends on 11) The mass spectrometer of claim 11, wherein the charged-particle detector comprises an ion detector.