# US 11,309,089 B2 · Human metabolic condition management

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- Number: US 11,309,089 B2
- Document ID: US11309089B2
- Status: Granted
- Kind: B2
- Application number: 16/701,401
- Filed: 2019-12-03
- Published: 2020-07-09
- Granted: 2022-04-19
- Earliest claimed: 2014-10-17
- Applicants: Bradley E. Kahlbaugh
- Inventors: Bradley E. Kahlbaugh
- Web page: https://patentgrep.com/patent/US11309089B2

## CPC

- G16H 50/50: for simulation or modelling of medical disorders
- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 5/7275: {Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor}
- A61M 5/14244: {adapted to be carried by the patient, e.g. portable on the body}
- A61M 5/1723: {using feedback of body parameters, e.g. blood sugar or pressure}
- G16H 20/10: relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H 20/40: relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
- G16H 20/60: relating to nutrition control, e.g. diets
- G16H 40/63: for local operation
- G16H 50/30: for calculating health indices; for individual health risk assessment
- A61M 2005/1726: {the body parameters being measured at, or proximate to, the infusion site}
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

Systems and methods for extracting blood glucose patterns and suggesting a behavior may include receiving, at a computing device comprising a processor, temporal data including information regarding glucose readings; identifying, by the computing device, at least one pattern based on metabolite levels extracted from the temporal data the model including variables corresponding to each of the patterns; formulating, by the computing device, a model for predicting a metabolic response; and storing the model on a data storage device. Based on the model, the behavior may be suggested to maintain a blood glucose level within a desired range.

## Claims

### Claim 1

A method comprising:
receiving, at a computing device comprising a processor, an indication of a food; a medication, or a combination of food and medication to be ingested by a user;
identifying, by the computing device, a metabolic rate for the food, the medication, or the combination of food and medication to be ingested;
formulating, by the computing device, a model for predicting a metabolite level change based on the metabolic rate for the food, the medication, or the combination of food and medication to be ingested, the model including variables corresponding to the food, the medication, or the combination of food and medication to be ingested;
validating the model against a subsample of temporal data not used to formulate the model;
storing the model on a data storage device;
receiving, at the computing device, a behavior input from a user, the behavior input including an indication of an ingestion of the food, the medication, or the combination of food and medication to be ingested;
determining, by the computing device, a metabolite level change based at least in part on the model;
selecting, by the computing device, a recommended behavior;
outputting the recommended behavior to a display associated with the computing device; and
performing the recommended behavior by the user.

### Claim 2 (depends on 1)

The method of claim 1, wherein the metabolic rate for the food, the medication, or the combination of food and medication to be ingested includes an absolute value for glucose.

### Claim 3 (depends on 1)

The method of claim 1, wherein the metabolic rate for the food, the medication, or the combination of food and medication to be ingested includes an increase in a blood glucose level.

### Claim 4 (depends on 1)

The method of claim 1, wherein the metabolic rate for the food, the medication, or the combination of food and medication to be ingested includes a decrease in a blood glucose level.

### Claim 5 (depends on 1)

The method of claim 1, wherein the temporal data includes exercise activities engaged in by the user that result in a change in a blood glucose level.

### Claim 6 (depends on 1)

The method of claim 1, wherein the temporal data includes the metabolite levels recorded over a time interval.

### Claim 7 (depends on 1)

The method of claim 1, wherein the model is formulated according to at least one of a statistical analysis, a Monte Carlo simulation, a single variable regression analysis, and a multivariable regression analysis.

### Claim 8 (depends on 1)

The method of claim 1, wherein receiving the temporal data includes receiving updated temporal data, the method further comprising:
identifying an updated metabolic rate based on metabolite levels extracted from the updated temporal data; and
wherein validating the model includes validating the model against the updated metabolic rate.

### Claim 9 (depends on 8)

The method of claim 8, further comprising formulating a new model when the model does not validate against the updated metabolic rate.

### Claim 10 (depends on 1)

The method of claim 1, wherein the recommended behavior includes two or more coupled metabolic effects.

### Claim 11

A system comprising:
a display;
a processor in electrical communication with the display; and
a memory that store instructions that, when executed by the processor, cause the processor to perform operations comprising:
receiving an indication of a food, a medication, or a combination of food and medication to be ingested by a user,
identifying a metabolic rate for the food, the medication, or the combination of food and medication to be ingested,
formulating a model for predicting a metabolite level change based on the metabolic rate for the food, the medication, or the combination of food and medication to be ingested, the model including variables corresponding to the food, the medication, or the combination of food and medication to be ingested,
validating the model against a subsample of temporal data not used to formulate the model,
storing, to the memory, the model,
receiving a behavior input from a user, the behavior input including an indication of an ingestion of the food, the medication, or the combination of food and medication to be ingested,
determining a metabolite level change based at least in part on the model,
selecting a recommended behavior,
outputting the recommended behavior to a display associated with the computing device, and
receiving an indication the user accepted the recommendation.

### Claim 12 (depends on 1)

The system of claim 1, wherein the metabolic rate for the food, the medication, or the combination of food and medication to be ingested includes an absolute value for glucose and an increase in a blood glucose level.

### Claim 13 (depends on 11)

The system of claim 11, wherein the metabolic rate for the food, the medication, or the combination of food and medication to be ingested includes a decrease in a blood glucose level.

### Claim 14 (depends on 11)

The system of claim 11, wherein the temporal data includes exercise activities engaged in by the user that result in a change in a blood glucose level.

### Claim 15 (depends on 11)

The system of claim 11, wherein the temporal data includes the metabolite levels recorded over a time interval.

### Claim 16 (depends on 11)

The system of claim 11, wherein the model is formulated according to at least one of a statistical analysis, a Monte Carlo simulation, a single variable regression analysis, and a multivariable regression analysis.

### Claim 17 (depends on 11)

The system of claim 11, wherein receiving the temporal data includes receiving updated temporal data, the method further comprising:
identifying an updated metabolic rate based on metabolite levels extracted from the updated temporal data; and
wherein validating the model includes validating the model against the updated metabolic rate.

### Claim 18 (depends on 17)

The system of claim 17, further comprising formulating anew model when the model does not validate against the updated metabolic rate.

### Claim 19 (depends on 11)

The system of claim 11, wherein the recommended behavior includes two or more coupled metabolic effects.

### Claim 20 (depends on 11)

The system of claim 11, wherein the system is one of a blood glucose meter, an infusion pump, and a smartphone.