# US 11,307,313 B2 · System, method, and detector module for pet imaging

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- Number: US 11,307,313 B2
- Document ID: US11307313B2
- Status: Granted
- Kind: B2
- Application number: 15/793,959
- Filed: 2017-10-25
- Published: 2019-02-28
- Granted: 2022-04-19
- Earliest claimed: 2017-08-30
- Assignees: Shanghai United Imaging Healthcare Co., Ltd.
- Applicants: Shanghai United Imaging Healthcare Co., Ltd.
- Inventors: Ze Chen; Ting Lu
- Web page: https://patentgrep.com/patent/US11307313B2

## CPC

- G01T 1/2002: {Optical details, e.g. reflecting or diffusing layers}
- A61B 5/0059: {using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455)}
- A61B 6/4258: {for detecting non x-ray radiation, e.g. gamma radiation (A61B6/037 takes precedence)}
- G01N 21/6408: {with measurement of decay time, time resolved fluorescence}
- G01T 1/1642: {using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras}
- G01T 1/1644: {using an array of optically separate scintillation elements permitting direct location of scintillations (G01T1/1645 takes precedence)}
- G01T 1/2985: {In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis); (using external radiation sources A61B6/02)}
- G01T: MEASUREMENT OF NUCLEAR OR X-RADIATION (radiation analysis of materials, mass spectrometry G01N23/00; tubes for determining the presence, intensity, density or energy of radiation or particles H01J47/00)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present disclosure relates to a system for PET imaging. The system may include a detector module and an electronics module. The detector module may include a scintillator array having N rows of scintillators arranged in a first direction and M columns of scintillators arranged in a second direction, a first set of photosensors coupled to the scintillator array and extending in the second direction, and a second set of photosensors coupled to the scintillator array and extending in the first direction. The electronics module may detect a first set of electrical signals generated by the first set of photosensors and a second set of electrical signals generated by the second set of photosensors, and identify a scintillator within the scintillator array that has interacted with an impinging radiation ray relating to an electrical signal of the first set of electrical signals or the second set of electrical signals.

## Claims

### Claim 1

A PET system, comprising:
a detector module configured to receive radiation rays and generate a plurality of light signals in response to the received radiation rays, the detector module comprising:
a scintillator array having N rows of scintillators and M columns of scintillators, each row of scintillators being arranged in a first direction, each column of scintillators being arranged in a second direction;
a first set of photosensors optically coupled to a first surface of the scintillator array, each photosensor of the first set of photosensors extending longitudinally in the second direction so as to be optically coupled to two or more scintillators in the second direction and being optically coupled to two rows of scintillators arranged in the first direction, each scintillator in the scintillator array being optically coupled to only one photosensor of the first set of photosensors; and
a second set of photosensors optically coupled to a second surface of the scintillator array, each photosensor of the second set of photosensors extending longitudinally in the first direction so as to be optically coupled to two or more scintillators in the first direction and being optically coupled to two columns of scintillators arranged in the second direction, each scintillator in the scintillator array being optically coupled to only one photosensor of the second set of photosensors; and
an electronics module coupled to the first set of photosensors and the second set of photosensors, the electronics module being configured to:
detect a first set of electrical signals generated by the first set of photosensors and a second set of electrical signals generated by the second set of photosensors; and
identify a scintillator within the scintillator array that has interacted with an impinging radiation ray relating to an electrical signal of the first set of electrical signals or the second set of electrical signals.

### Claim 2 (depends on 1)

The PET system of claim 1, wherein the first direction is approximately perpendicular to the second direction.

### Claim 3 (depends on 1)

The PET system of claim 1, wherein an area of a first photosensor of the first set of photosensors is less than a sum of areas of the two rows of scintillators to which the first photosensor is coupled, or an area of a second photosensor of the second set of photosensors is less than a sum of areas of the two columns of scintillators to which the second photosensor is coupled.

### Claim 4 (depends on 1)

The PET system of claim 1, wherein a number of the first set of photosensors is no less than a half of M, or a number of the second set of photosensors is no less than a half of N.

### Claim 5 (depends on 1)

The PET system of claim 1, wherein the electronics module is further configured to determine a depth of interaction of the impinging radiation ray in the identified scintillator.

### Claim 6 (depends on 1)

The PET system of claim 1, wherein the electronics module comprises:
a plurality of analog-to-digital converters (ADC) configured to digitize the first set of electrical signals and the second set of electrical signals; and
a processor configured to identify, based on the digitized first set of electrical signals and the digitized second set of electrical signals, the scintillator within the scintillator array that has interacted with the impinging radiation ray.

### Claim 7 (depends on 6)

The PET system of claim 6, wherein the electronics module further comprises:
a lower limit detection (LLD) circuit, or a constant fraction discriminator (CFD) circuit; and
a time-to-digital converter (TDC) configured to determine an interaction time when the impinging radiation ray interacts with the identified scintillator.

### Claim 8 (depends on 1)

The PET system of claim 1, wherein a spacing between each pair of neighboring photosensors of the first set of photosensors extends along the first direction such that each scintillator in the scintillator array being optically coupled to only one photosensor of the first set of photosensors.

### Claim 9 (depends on 1)

The PET system of claim 1, wherein a spacing between each pair of neighboring photosensors of the second set of photosensors extends along the second direction such that each scintillator in the scintillator array being optically coupled to only one photosensor of the second set of photosensors.

### Claim 10

A method for PET imaging, comprising:
detecting, using a scintillator array, a plurality of radiation rays, wherein the scintillator array includes N rows of scintillators and M columns of scintillators, each row of scintillators being arranged in a first direction, each column of scintillators being arranged in a second direction;
generating, using a first set of photosensors, a first set of electrical signals based on the plurality of radiation rays, wherein the first set of photosensors are optically coupled to a first surface of the scintillator array, each photosensor of the first set of photosensors extending longitudinally in the second direction so as to be optically coupled to two or more scintillators in the second direction and being optically coupled to two rows of scintillators arranged in the first direction, each scintillator in the scintillator array being optically coupled to only one photosensor of the first set of photosensors;
generating, using a second set of photosensors, a second set of electrical signals based on the plurality of radiation rays, wherein the second set of photosensors are optically coupled to a second surface of the scintillator array, each photosensor of the second set of photosensors extending longitudinally in the first direction so as to be optically coupled to two or more scintillators in the first direction and being optically coupled to two columns of scintillators arranged in the second direction, each scintillator in the scintillator array being optically coupled to only one photosensor of the second set of photosensors; and
identifying, using an electronics module, a scintillator within the scintillator array that has interacted with an impinging radiation ray relating to an electrical signal of the first set of electrical signals or the second set of electrical signals.

### Claim 11 (depends on 10)

The method of claim 10, wherein the identifying, using an electronics module, a scintillator within the scintillator array that has interacted with an impinging radiation ray relating to an electrical signal of the first set of electrical signals or the second set of electrical signals, comprises:
determining a first position of the impinging radiation ray that has interacted with the scintillator array in the first direction, based on the first set of electrical signals;
determining a second position of the impinging radiation ray that has interacted with the scintillator array in the second direction, based on the second set of electrical signals; and
identifying, based on the first position and the second position, the scintillator within the scintillator array that has interacted with the impinging radiation ray.

### Claim 12 (depends on 10)

The method of claim 10, further comprising:
identifying a depth of interaction of the impinging radiation ray in the identified scintillator, based on the first set of electrical signals and the second set of electrical signals.

### Claim 13 (depends on 10)

The method of claim 10, further comprising:
determining, using a time-to-digital converter (TDC), an interaction time when the impinging radiation ray interacts with the identified scintillator.

### Claim 14 (depends on 11)

The method of claim 11, wherein the first direction corresponds to an X axis direction, the first position of the impinging radiation ray corresponds to a position in the X axis direction, and wherein the determining the first position of the impinging radiation ray that has interacted with the scintillator array in the first direction comprises:
identifying a position of a first photosensor that generates an electrical signal with maximum energy of the first set of electrical signals in the X axis direction as the first position; or
identifying a position of an energy centroid of the first set of electrical signals in the X axis direction as the first position.

### Claim 15 (depends on 11)

The method of claim 11, wherein the second direction corresponds to a Y axis direction, the second position of the impinging radiation ray corresponds to a position in the Y axis direction, and wherein the determining the second position of the impinging radiation ray that has interacted with the scintillator array in the second direction comprises:
identifying a position of a second photosensor that generates an electrical signal with maximum energy of the second set of electrical signals in the Y axis direction as the second position; or
identifying a position of an energy centroid of the second set of electrical signals in the Y axis direction as the second position.

### Claim 16 (depends on 12)

The method of claim 12, wherein the depth of interaction of the impinging radiation ray in the identified scintillator corresponds to a position in a Z axis direction that is perpendicular to the first direction and the second direction, and wherein the identifying the depth of interaction of the impinging radiation ray in the identified scintillator comprises:
determining, based on a ratio of first energy relating to the first set of electrical signals to second energy relating to the first set of electrical signals and the second set of electrical signals, a proportional distribution coefficient; and
determining, based on the proportional distribution coefficient, the depth of interaction of the impinging radiation ray.

### Claim 17 (depends on 13)

The method of claim 13, wherein the impinging radiation ray interacts with the scintillator array from the first surface or the second surface of the scintillator array, and wherein the determining an interaction time comprises:
determining a sum of the first set of electrical signals or the second set of electrical signals; and
determining the interaction time based on the sum of the first set of electrical signals or the second set of electrical signals.

### Claim 18 (depends on 10)

The method of claim 10, wherein the scintillator array further includes S rows of blocks arranged in the first direction and T columns of blocks arranged in the second direction, each block including N rows of scintillators and M columns of scintillators, and the method further comprising:
identifying a sum of S electrical signals generated by S photosensors that are optically coupled to the first surface of the scintillator array and arranged in a same column of the T columns of blocks as one of the first set of electrical signals; and
identifying a sum of T electrical signals generated by T photosensors that are optically coupled to the second surface of the scintillator array and arranged in a same row of the S rows of blocks as one of the second set of electrical signals.

### Claim 19

A detector module configured to receive radiation rays and generate a plurality of light signals in response to the received radiation rays, comprising:
a scintillator array having N rows of scintillators and M columns of scintillators, each row of scintillators being arranged in a first direction, each column of scintillators being arranged in a second direction;
a first set of photosensors optically coupled to a first surface of the scintillator array, each photosensor of the first set of photosensors extending longitudinally in the second direction so as to be optically coupled to two or more scintillators in the second direction and being optically coupled to two rows of scintillators arranged in the first direction, each scintillator in the scintillator array being optically coupled to only one photosensor of the first set of photosensors; and
a second set of photosensors optically coupled to a second surface of the scintillator array, each photosensor of the second set of photosensors extending longitudinally in the first direction so as to be optically coupled to two or more scintillators in the first direction and being optically coupled to two columns of scintillators arranged in the second direction, each scintillator in the scintillator array being optically coupled to only one photosensor of the second set of photosensors.

### Claim 20 (depends on 19)

The detector module of claim 19, wherein a number of the first set of photosensors is no less than a half of M, or a number of the second set of photosensors is no less than a half of N.
