# US 11,307,277 B2 · Magnetization transfer based metric for chemical exchange saturation transfer MRI > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,307,277 B2 - Document ID: US11307277B2 - Status: Granted - Kind: B2 - Application number: 16/960,112 - Filed: 2019-01-02 - Published: 2021-03-04 - Granted: 2022-04-19 - Earliest claimed: 2018-01-11 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Jochen Keupp - Web page: https://patentgrep.com/patent/US11307277B2 ## CPC - G01R 33/5605: {by transferring coherence or polarization from a spin species to another, e.g. creating magnetization transfer contrast [MTC], polarization transfer using nuclear Overhauser enhancement [NOE]} - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - G01R 33/4838: {using spatially selective suppression or saturation of MR signals} - G01R 33/5608: {Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels (image data processing or generation, in general G06T)} - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A medical analysis system (111) for processing magnetic resonance imaging (MRI), data (170) from a target volume (208) in a subject (218) includes a memory (107) for storing machine executable instructions; and a processor (103) for controlling the system (111). Execution of the machine executable instructions causes the processor (103) to: determine from the MRI data (103) chemical exchange saturation transfer (CEST) voxel values corresponding to a transfer of saturation between a predefined pool of protons and water protons, the pool of protons having a predefined chemical shift; and weight the CEST values in order to distinguish CEST values of fluid-rich tissues (507) from CEST values of solid tissues (505) in the target volume (208), wherein the fluid-rich tissue comprises an amount of fluid higher than a predefined minimum amount of fluid. ## Claims ### Claim 1 A medical analysis system for processing magnetic resonance imaging (MRI) data from a target volume in a subject, the target volume includes fluid-rich tissues and solid tissues, wherein the fluid-rich tissue includes an amount of fluid higher than a predefined minimum amount of fluid, the system comprising: a memory configured to store machine executable instructions; and a processor for controlling the system, wherein execution of the machine executable instructions causes the processor to: determine from the MRI data chemical exchange saturation transfer, CEST, voxel values corresponding to a transfer of saturation between a predefined pool of protons and water protons, the pool of protons having a predefined chemical shift; weight the CEST values in order to distinguish CEST values of fluid-rich tissues from CEST values of solid tissues in the target volume, the MRI data being acquired using predefined MRI sequences, wherein the MRI data comprises non-saturated data at a predefined large saturation frequency offset or without RF saturation and saturation transfer data at N saturation frequency offsets, wherein N>=2, wherein the weighting comprises: performing a quantitative tissue scoring using a subset of the saturation transfer data comprising N2 saturation frequency offsets and the non-saturated data in order to assess fluid content and solid tissue content at each voxel in the MRI data, generating a correction function using results of the scoring, and using the correction function to weight the CEST value of each voxel, wherein using the correction function to weight the CEST values comprises multiplying a correction factor CF=ε×(MTR(+Δωc)+MTR(−Δωc)) with CEST values, wherein ±Δωc are the saturation frequency offsets and ε is a factor that is determined such that the application of the correction factor results in the CEST values within the fluid-rich tissues being rescaled while the CEST values remain unchanged for the solid tissues. ### Claim 2 (depends on 1) The system of claim 1, wherein the proton pool comprises amide protons, wherein the CEST values are amide proton transfer weighted, APTw, values. ### Claim 3 (depends on 1) The system of claim 1, the weighting being performed such that the CEST values within the fluid-rich tissues are rescaled while the CEST values remain unchanged for the solid tissues. ### Claim 4 (depends on 1) The system of claim 1, the execution of the machine executable instructions further causes the processor to generate from the subset of the saturation transfer data and non-saturated data N2 magnetization transfer ratios, MTRs, for each voxel at N2 saturation frequency offsets, wherein N2≤N, and combine the N2 MTRs for each voxel, wherein the quantitative tissue scoring is performed using the combined MTRs. ### Claim 5 (depends on 4) The system of claim 4, wherein the combined MTR for a given voxel is a weighted sum of the N2 MTRs of the given voxel. ### Claim 6 (depends on 1) The system of claim 1, wherein the MRI data comprises saturation transfer data at N saturation frequency offsets and non-saturated MRI data of the target volume, the execution of the machine executable instructions further causes the processor to generate from a subset of the saturation transfer data and the non-saturated MRI data magnetization transfer ratios, MTRs, for each voxel at N3 saturation frequency offsets, wherein N3≤N, wherein the CEST values being obtained by an analysis of the distribution of MTRs in comparison to a distribution which is symmetric with respect to the water resonance frequency. ### Claim 7 (depends on 6) The system of claim 6, wherein the CEST value of a given voxel is obtained by a magnetic transfer asymmetry analysis, MTRasym, which is the difference between the MTRs of the given voxel at two frequency offsets being symmetrically positioned on opposite sides of the water resonance frequency. ### Claim 8 (depends on 1) The system of claim 1, wherein the MRI data comprises saturation transfer data at multiple saturation frequency offsets having a predefined chemical shift difference with respect to the water resonance frequency. ### Claim 9 (depends on 1) The system of claim 1, wherein the saturation transfer data is corrected for B0 field inhomogeneity before the saturation transfer data being used. ### Claim 10 (depends on 1) The system of claim 1, wherein the fluid-rich tissue comprises at least one of the following tissue types: a cyst, hemorrhage, cerebrospinal fluid (CSF), edema, inflamed tissue, fluid parts of necrotic tissue or other fluid-rich tissues. ### Claim 11 (depends on 1) An MRI system comprising the medical analysis system of claim 1, and an acquisition component for acquiring the MRI data. ### Claim 12 A method for processing magnetic resonance imaging MRI data from a target volume in a subject, the method comprising: determining from the MRI data chemical exchange saturation transfer, CEST, voxel values corresponding to a transfer of saturation between a predefined pool of protons and water protons, the pool of protons having a predefined chemical shift; weighting the CEST values in order to distinguish CEST values of fluid-rich tissues from CEST values of solid tissues in the target volume, wherein the fluid-rich tissue comprises an amount of fluid higher than a predefined minimum amount of fluid, the MRI data being acquired using predefined MRI sequences, wherein the MRI data comprises non-saturated data at a predefined large saturation frequency offset or without RF saturation and saturation transfer data at N saturation frequency offsets, wherein N>=2, wherein the weighting comprises: performing a quantitative tissue scoring using a subset of the saturation transfer data comprising N2 saturation frequency offsets and the non-saturated data in order to assess fluid content and solid tissue content at each voxel in the MRI data, generating a correction function using results of the scoring, and using the correction function to weight the CEST value of each voxel, wherein using the correction function to weight the CEST values comprises multiplying a correction factor CF=ε×(MTR(+Δωc)+MTR(−Δωc)) with CEST values, wherein ±Δωc are the saturation frequency offsets and ε is a factor that is determined such that the application of the correction factor results in the CEST values within the fluid-rich tissues being rescaled while the CEST values remain unchanged for the solid tissues. ### Claim 13 A computer program product comprising machine executable instructions stored on a non-transitory computer readable medium for execution by a processor, wherein execution of the machine executable instructions causes the processor to process magnetic resonance imaging MRI data from a target volume in a subject by: determining from the MRI data chemical exchange saturation transfer, CEST, voxel values corresponding to a transfer of saturation between a predefined pool of protons and water protons, the pool of protons having a predefined chemical shift; and weighting the CEST values in order to distinguish CEST values of fluid-rich tissues from CEST values of solid tissues in the target volume, wherein the fluid-rich tissue comprises an amount of fluid higher than a predefined minimum amount of fluid, the MRI data being acquired using predefined MRI sequences, wherein the MRI data comprises non-saturated data at a predefined large saturation frequency offset or without RF saturation and saturation transfer data at N saturation frequency offsets, wherein N>=2, wherein the weighting comprises: performing a quantitative tissue scoring using a subset of the saturation transfer data comprising N2 saturation frequency offsets and the non-saturated data in order to assess fluid content and solid tissue content at each voxel in the MRI data, generating a correction function using results of the scoring, and using the correction function to weight the CEST value of each voxel, wherein using the correction function to weight the CEST values comprises multiplying a correction factor CF=ε×(MTR(+Δωc)+MTR(−Δωc)) with CEST values, wherein ±Δωc are the saturation frequency offsets and ε is a factor that is determined such that the application of the correction factor results in the CEST values within the fluid-rich tissues being rescaled while the CEST values remain unchanged for the solid tissues.