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US 11,307,204 B2Granted
5-ALA for detection of brain tumors
AssigneePioma, Inc.
InventorAlan M. Ezrin
Life of this patent
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Abstract
The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) and detecting the conversion of 5-ALA to protoporphyrin IX (PPIX) associated with brain-derived microparticles.
Claims13
A method for detecting a tumor, wherein the method comprises
- (a) administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ALA) to a subject;
- (b) isolating tumor-derived microparticles from a biological sample from the subject;
- and
- (c) detecting a level of conversion of 5-ALA to protoporphyrin IX (PPIX) associated with the tumor-derived microparticles in the biological sample from the subject, thereby detecting the tumor,
- wherein the tumor is selected from the group consisting of ovarian, breast, pancreatic, prostate, lung, colorectal, renal and bladder tumor.
2 more elements
Dependencies are inferred from the claim text.