# US 11,306,871 B2 · Pressurized sub-cooled cryogenic system and method of use > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,306,871 B2 - Document ID: US11306871B2 - Status: Granted - Kind: B2 - Application number: 16/042,411 - Filed: 2018-07-23 - Published: 2018-11-29 - Granted: 2022-04-19 - Earliest claimed: 2014-04-16 - Assignees: CPSI Holdings LLC - Applicants: CPSI Holdings LLC - Inventors: John M. Baust; Joshua T. Smith; Anthony T. Robilotto; Jennie F. McKain - Web page: https://patentgrep.com/patent/US11306871B2 ## CPC - F17C 1/00: Pressure vessels, e.g. gas cylinder, gas tank, replaceable cartridge (pressurised apparatus for purposes other than storage, see the relevant subclasses such as A62C, B05B; associated with vehicles, see the appropriate subclass of classes B60 - B64; pressure vessels in general F16J12/00 {; autoclaves B01J3/04; tank vehicles B60P3/22; railway tank wagons for carrying fluent materials B61D5/00; accumulators for supplying fluid under pressure F15B1/04; liquefied gas stoves F24C3/00}) - A61B 18/02: by cooling, e.g. cryogenic techniques - F17C 3/00: Vessels not under pressure - F17C 5/02: for filling with liquefied gases - A61B 2018/00714: {Temperature} - A61B 2018/00744: {Fluid flow} - A61B 2018/00791: {Temperature} - A61B 2018/0293: {using an instrument interstitially inserted into the body, e.g. needle} - A61B 2090/064: {for measuring force, pressure or mechanical tension} - F17C 2201/0109: with exteriorly curved end-piece - F17C 2201/032: with substantially vertical main axis - F17C 2201/056: Small (<1 m3) - F17C 2203/0329: Foam - F17C 2203/0391: by vacuum - F17C 2203/0643: Stainless steels - F17C 2205/0107: Frames - F17C 2205/0161: with wheels - F17C 2205/0367: Arrangements in parallel - F17C 2221/011: Oxygen - F17C 2221/012: Hydrogen - F17C 2221/014: Nitrogen - F17C 2221/016: Noble gases (Ar, Kr, Xe) - F17C 2221/017: Helium - F17C 2221/035: Propane butane, e.g. LPG, GPL - F17C 2223/0169: subcooled - F17C 2223/035: High pressure (>10 bar) - F17C 2223/036: Very high pressure (>80 bar) - F17C 2227/0341: using another fluid - F17C 2227/0353: using cryocooler - F17C 2227/0374: in the liquid - F17C 2250/032: using computers - F17C 2250/0408: Level of content in the vessel - F17C 2250/0439: Temperature - F17C 2270/02: for medical applications - F17C 2270/0509: "Dewar" vessels - Y02E 60/32: Hydrogen storage - F17C: VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES (storing fluids in natural or artificial cavities or chambers in the earth B65G5/00; construction or assembling of bulk storage containers employing civil-engineering techniques E04H7/00; variable-capacity gas-holders F17B; liquefaction or refrigeration machines, plants, or systems F25) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - Y02E: REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION ## Abstract A cryogenic system as well as a method of generating a pressurized, sub-cooled mixed-phase cryogen and a method of delivering such a cryogen to a cryoprobe are disclosed. In an embodiment, the cryogenic system includes a reservoir containing a liquid cryogen and a sub-cooling coil immersed in the liquid cryogen. The cryogen is supplied to the sub-cooling coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the sub-cooling coil. This pressurized mixed phase cryogen is provided via supply line to a cryo-device for use. ## Claims ### Claim 1 A cryogenic system comprising: a reservoir containing a liquid cryogen; an enclosure in which the reservoir is disposed; a heat exchange coil immersed in a pressurized cryogen, wherein the pressurized cryogen is supplied to the heat exchange coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the heat exchange coil; a cryoprobe fluidly connected to the heat exchange coil by a supply line such that the pressurized mixed phase cryogen is delivered to the cryoprobe, wherein the cryoprobe further comprises; an umbilical line coupled to the enclosure; a probe handle coupled to the umbilical line; and a probe shaft having an outer sheath disposed thereon, the probe shaft extending from the probe handle, wherein the supply line is disposed within the umbilical, the probe handle, and the probe shaft, placing the cryoprobe in fluid communication with the heat exchange coil within the enclosure; and a vacuum lumen disposed within the probe shaft; a return line configured to conduct the used cryogen away from the cryoprobe, wherein the return line conducts the used cryogen to a heat exchanger venting system. ### Claim 2 (depends on 1) The cryogenic system of claim 1, further comprising a boiling chamber disposed at a distal tip of the cryoprobe, wherein the return line axially extends a first distance into the boiling chamber, and the supply line axially extends a second, longer distance into the boiling chamber, such that the supply line terminates nearer to the distal tip of the cryoprobe than the return line. ### Claim 3 (depends on 1) The cryogenic system of claim 1, wherein the vacuum lumen is in fluid connection with a vacuum pump disposed within the enclosure. ### Claim 4 (depends on 1) The cryogenic system of claim 1, wherein the at least one pressurized gas cryogen supply further comprises: two or more pressurized cryogen cylinder linked together in series or in parallel. ### Claim 5 (depends on 1) The cryogenic system of claim 1, further comprising at least one pressurized gas cryogen supply including: a low pressure cryogen supply and a compressor for pressurizing the pressurized cryogen. ### Claim 6 (depends on 1) The cryogenic system of claim 1, wherein the liquid cryogen contained within the reservoir is a liquefied gas cryogen and is one of: nitrogen, argon, oxygen, helium, hydrogen, propane, ethylene glycol, propanediol, or alcohol. ### Claim 7 (depends on 1) The cryogenic system of claim 1, further comprising: at least one sensor for monitoring one or more of: a pressure of a pressurized cryogen supplied to the heat exchange coil, a pressure of the pressurized mixed phase cryogen output from the heat exchange coil, a temperature of the pressurized cryogen supplied to the heat exchange coil, a temperature of the pressurized mixed phase cryogen output from the heat exchange coil, a temperature of the liquid cryogen contained within the reservoir, a temperature of a tip of the cryoprobe, a flow rate of the pressurized cryogen supplied to the heat exchange coil, a flow rate of the pressurized mixed phase cryogen output from the heat exchange coil, a vessel fluid level in the reservoir, or a vessel fluid level in a pressurized cryogen supply. ### Claim 8 (depends on 7) The cryogenic system of claim 7, further comprising: a control center including a computer-readable storage medium which, when executed by a computing device, causes the computing device to carry out: receiving feedback from the at least one sensor; and based on the feedback, controlling at least one operation parameter of the cryogenic system, the at least one operation parameter including one or more of: the pressure of a pressurized cryogen supplied to the heat exchange coil, the pressure of the pressurized mixed phase cryogen output from the heat exchange coil, the temperature of the pressurized cryogen supplied to the heat exchange coil, the temperature of the pressurized mixed phase cryogen output from the heat exchange coil, the temperature of the liquid cryogen contained within the reservoir, the temperature of a tip of the cryoprobe, the flow rate of the pressurized cryogen supplied to the heat exchange coil, the flow rate of the pressurized mixed phase cryogen output from the heat exchange coil, the vessel fluid level in the reservoir, or the vessel fluid level in a pressurized cryogen supply. ### Claim 9 (depends on 1) The cryogenic system of claim 1, further comprising a plurality of heat exchange coils immersed in liquid cryogen, wherein the pressurized cryogen gas is supplied to each heat exchange coil and wherein the pressurized cryogen gas is cooled in each coil to produce a pressurized mixed phase cryogen. ### Claim 10 (depends on 1) The cryogenic system of claim 1, further comprising one or more pressure regulators on a cryogen gas input line configured to adjust a pressure of the incoming pressurized cryogen supplied to the heat exchange coil. ### Claim 11 (depends on 1) The cryogenic system of claim 1, further comprising an ultra-cold refrigeration system configured to cool the reservoir, wherein the ultra-cold refrigeration system is capable of cooling the liquid cryogen from −12° C. to −218° C. ### Claim 12 (depends on 8) The cryogenic system of claim 8, further comprising: a multi-component cryogenic system, wherein in the multi-component cryogenic system further comprises: a cryogen cart; a control console; and a plurality of connection lines, including one or more connection lines to connect: the control console and cryogen cart, and wherein the connection lines include a cryogen connection, an electrical connection, and a communication connection between the cryogen cart and the control console. ### Claim 13 (depends on 1) The cryogenic system of claim 1, wherein the heat exchanger venting system is configured to conduct the used cryogen away from the return line, and wherein the heat exchanger venting system is configured to warm the cryogen that is collected from the return line, and to vent the warmed used cryogen from the cryogenic system. ### Claim 14 (depends on 1) The cryogenic system of claim 1, further comprising: at least one pressurized gas cryogen supply including: a pressurized cryogen cylinder configured to supply the pressurized cryogen to the heat exchange coil at a first pressure, wherein the heat exchange coil is configured to output the pressurized cryogen to the cryoprobe at a second pressure that is lower than the first pressure.