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US 11,306,137 B2Granted
Antibody binding agents that bind Acinetobactor and uses thereof
AssigneeLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
InventorsBrad Spellberg, Kevin Bruhn, Travis Nielsen
Life of this patent
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Abstract
Presented herein, in certain embodiments, are compositions comprising antibody binding agents that specifically bind to A. baumannii and inhibit and/or block A. baumannii infection, and uses thereof.
Claims18
A chimeric, CDR-grafted, humanized, or bispecific antibody or antigen binding portion thereof that specifically binds to A. baumannii, comprising:
- a CDR-L1 comprising the amino acid sequence of SEQ ID NO:4;
- a CDR-L2 comprising the amino acid sequence of SEQ ID NO:8;
- a CDR-L3 comprising the amino acid sequence of SEQ ID NO:12;
- a CDR-H1 comprising the amino acid sequence of SEQ ID NO:16;
- a CDR-H2 comprising the amino acid sequence of SEQ ID NO:20;
- and
- a CDR-H3 comprising the amino acid sequence of SEQ ID NO:24.
4 more elements
A chimeric, CDR-grafted, humanized, or bispecific antibody or antigen binding portion thereof that specifically binds to A. baumannii, comprising:
- a CDR-L1 comprising the amino acid sequence of SEQ ID NO:4;
- a CDR-L2 comprising the amino acid sequence of SEQ ID NO:8;
- a CDR-L3 comprising the amino acid sequence of SEQ ID NO:12;
- a CDR-H1 comprising the amino acid sequence of SEQ ID NO:55;
- a CDR-H2 comprising the amino acid sequence of SEQ ID NO:59;
- and
- a CDR-H3 comprising the amino acid sequence of SEQ ID NO:63.
4 more elements
Dependencies are inferred from the claim text.