# US 11,306,121 B2 · Composition for muscle relaxation

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- Number: US 11,306,121 B2
- Document ID: US11306121B2
- Status: Granted
- Kind: B2
- Application number: 17/251,609
- Filed: 2019-10-22
- Published: 2021-08-12
- Granted: 2022-04-19
- Earliest claimed: 2018-12-26
- Assignees: Caregen Co., Ltd.
- Applicants: Caregen Co., Ltd.
- Inventors: Yong Ji Chung; Eun Mi Kim; Eung Ji Lee
- Web page: https://patentgrep.com/patent/US11306121B2

## CPC

- A61Q 19/008: {Preparations for oily skin}
- C07K 7/06: having 5 to 11 amino acids
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/1652: {Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623)}
- A61K 9/2018: {Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates}
- A61K 9/2059: {Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin}
- A61K 9/4825: {Proteins, e.g. gelatin (gelatin capsule shells with substantial amounts of other macromolecular substances A61K9/4816)}
- A61K 9/4866: {Organic macromolecular compounds}
- A61K 38/08: Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)}
- A61P 21/02: Muscle relaxants, e.g. for tetanus or cramps
- A61Q 19/08: Anti-ageing preparations
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a peptide exhibiting physiological activities and a composition including the peptide. Because the peptide of the present invention exhibits various physiological activities such as muscle relaxation, skin wrinkle improvement, sebum production suppression, and the like, the peptide may be used as an active ingredient in a pharmaceutical composition for muscle relaxation, or cosmetics for improving skin wrinkles, suppressing sebum production, or ameliorating acne.

## Claims

### Claim 1

A method for relaxing muscles in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition, wherein the pharmaceutical composition comprises an effective amount of a peptide comprising the amino acid sequence set forth in SEQ ID NO: 1.

### Claim 2 (depends on 1)

The method of claim 1, wherein the peptide is included at a content of 0.001% by weight to 60% by weight, based on 100% by weight of the pharmaceutical composition.

### Claim 3

A method for treating a neuromuscular disease in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition, wherein the pharmaceutical composition comprises an effective amount of a peptide comprising the amino acid sequence set forth in SEO ID NO: 1.

### Claim 4 (depends on 3)

The method of claim 3, wherein the neuromuscular disease comprises any one selected from the group consisting of eyelid twitching, torticollis, cervical dystonia, tonic blepharospasm, axillary hyperhidrosis, anal fissure, colpospasm, achalasia, a headache disorder, idiopathic and neurogenic detrusor overactivity, focal dystonia, temporomandibular joint pain/disorder, diabetic neuropathy, vocal cord dysfunction, strabismus, chronic neuropathy, facial muscular hypertrophy, detrusor-sphincter dyssynergia, and benign prostatic hyperplasia.

### Claim 5 (depends on 4)

The method of claim 4, wherein the headache disorder is migraine.

### Claim 6 (depends on 3)

The method of claim 3, wherein the peptide suppresses secretion of acetylcholine.

### Claim 7

A method for improving a skin condition in a subject in need thereof, the method comprising administering to the subject a cosmetic composition, wherein the cosmetic composition comprises an effective amount of a peptide comprising the amino acid sequence set forth in SEQ ID NO: 1.

### Claim 8 (depends on 7)

The method of claim 7, wherein the skin condition comprises skin wrinkles, sebum production, acne, or combinations thereof.

### Claim 9 (depends on 7)

The method of claim 7, wherein the peptide is included at a content of 0.001% by weight to 60% by weight, based on 100% by weight of the cosmetic composition.

### Claim 10 (depends on 7)

The method of claim 7, wherein the peptide increases expression of collagen.

### Claim 11 (depends on 1)

The method of claim 1, wherein the peptide suppresses secretion of acetylcholine.