# US 11,306,101 B2 · Substituted 1-oxo-isoindoline-5-carboxamide compounds, compositions thereof, and methods of treatment therewith

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- Number: US 11,306,101 B2
- Document ID: US11306101B2
- Status: Granted
- Kind: B2
- Application number: 16/887,766
- Filed: 2020-05-29
- Published: 2020-12-03
- Granted: 2022-04-19
- Earliest claimed: 2019-05-31
- Assignees: Celgene Corporation
- Applicants: Celgene Corporation
- Inventors: Frans Baculi; Katherine Northcote; Matthew D. Correa; Joshua Hansen; Laurie A. Lebrun; Chin-Chun Lu; Gang Lu; Mark A. Nagy; Sophie Peng; Sophie Perrin-Ninkovic
- Web page: https://patentgrep.com/patent/US11306101B2

## CPC

- C07D 491/107: with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- A61P 35/02: specific for leukemia
- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- C07D 401/14: containing three or more hetero rings
- C07D 405/14: containing three or more hetero rings
- C07D 413/14: containing three or more hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided herein are 1-oxo-isoindoline-5-carboxamide compounds having the following structure: wherein R1, R2, R3, R4 and n are as defined herein, compositions comprising an effective amount of a 1-oxo-isoindoline-5-carboxamide compound, and methods for treating or preventing disorders.

## Claims

### Claim 1

A compound of Formula (I)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof,
wherein:
R1 is C1-3 alkyl, or C1-3 fluoroalkyl;
R2 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-10 cycloalkyl, substituted or unsubstituted 3-6-membered heterocyclyl, substituted or unsubstituted C6-10 aryl, or substituted or unsubstituted 5-10-membered heteroaryl;
substituents on R2 when present, are selected from F, Cl, Br, CN, OH, OCH3, OCF3, OCH2CH3, O-n-propyl, O-isopropyl, O-n-butyl, O-sec-butyl, O-tert-butyl, O-cyclopropyl, O-cyclobutyl, O-phenyl, CH3, CH2CH3, CF3, CH2CF3, CH2NHCH3, CH2N(CH3)2, and a —(C0-3 alkyl)(3-6 membered heterocyclyl) selected from piperidyl, piperazinyl, morpholino, CH2-aziridyl, CH2-pyrrolidyl, CH2-piperazinyl, CH2-piperidyl, CH2-morpholinyl, and CH2(2-oxa-6-azaspiro[3.3]heptyl), wherein the —(C0-3 alkyl)(3-6 membered heterocyclyl) is optionally substituted with one or more F, Cl or CH3;
R3 is H;
R4 is halogen; and
n is 0-3.

### Claim 2 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (II)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 3 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (III)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 4 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (IV)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 5 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (V)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 6 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (VI)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 7 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (VII)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 8 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (VIII)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 9 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (IX)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 10 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (X)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 11 (depends on 1)

The compound of claim 1, wherein the compound is a compound of Formula (XI)
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 12 (depends on 1)

The compound of claim 1, wherein R1 is methyl, ethyl, n-propyl, isopropyl, CH2F, CHF2, CF3, CH2CH2F, CH2CHF2, CH2CF3, CHFCH3, CF2CH3, or CF2CF3.

### Claim 13 (depends on 1)

The compound of claim 1, wherein R1 is methyl, ethyl, isopropyl, CHF2, CF3, CH2CF3, or CF2CH3.

### Claim 14 (depends on 1)

The compound of claim 1, wherein R2 is substituted with one or more substituents selected from F, Cl, CN, OH, OCH3, OCF3, O-isopropyl, O-cyclopropyl, O-phenyl, CH3, CF3, CH2CF3, CH2N(CH3)2, and a —(C0-3 alkyl)(3-6 membered heterocyclyl) selected from morpholino, piperazinyl, CH2-aziridyl, CH2-pyrrolidyl, CH2-piperazinyl, CH2-morpholinyl, and CH2(2-oxa-6-azaspiro[3.3]heptyl), wherein the —(C0-3 alkyl)(3-6 membered heterocyclyl) is optionally substituted with one or more F or CH3.

### Claim 15 (depends on 1)

The compound of claim 1, wherein R2 is C1-6 alkyl, unsubstituted or substituted with one or more substituents independently selected from F, CN, and OH.

### Claim 16 (depends on 15)

The compound of claim 15, wherein R2 is CH3, isopropyl, ter-butyl, C(CH3)2CH2OH, C(CH3)2CN, or C(CH3)2CF3.

### Claim 17 (depends on 1)

The compound of claim 1, wherein R2 is C3-10 cycloalkyl, unsubstituted, or substituted with one or more substitutents independently selected from F, OH, CH3, C(CH3)2OH, and CF3.

### Claim 18 (depends on 17)

The compound of claim 17 wherein R2 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, spiro[3.5]nonyl, bicyclo[1.1.1]pentyl, or spiro[2.5]octyl.

### Claim 19 (depends on 1)

The compound of claim 1, wherein R2 is 3-6-membered heterocyclyl, unsubstituted, or substituted with one or more CH3, and CH2CF3.

### Claim 20 (depends on 19)

The compound of claim 19, wherein R2 is oxetanyl, tetrahydropyranyl or piperidyl.

### Claim 21 (depends on 1)

The compound of claim 1, wherein R2 is C6-10 aryl, unsubstituted or substituted with one or more substituents independently selected from F, Cl, CN, OH, OCH3, OCF3, O-isopropyl, O-cyclopropyl, O-phenyl, CH3, CF3, and CH2N(CH3)2; and —(C0-3 alkyl)(3-6 membered heterocyclyl) selected from piperazinyl, morpholino, CH2-aziridyl, CH2-pyrrolidyl, CH2-piperazinyl, CH2-morpholinyl, and CH2(2-oxa-6-azaspiro[3.3]heptyl), wherein the —(C0-3 alkyl)(3-6 membered heterocyclyl) is optionally substituted with one or more F, or CH3.

### Claim 22 (depends on 21)

The compound of claim 21, wherein R2 is phenyl.

### Claim 23 (depends on 1)

The compound of claim 1, wherein R2 is 5-10-membered heteroaryl, unsubstituted or substituted with one or more substituents independently selected from F, Cl, OCH3, CH3, CF3, and CH2N(CH3)2.

### Claim 24 (depends on 1)

The compound of claim 1, wherein R2 is pyrazolyl, pyridyl, pyrazinyl, or pyrimidyl.

### Claim 25 (depends on 1)

The compound of claim 1, wherein R4 is F or Cl.

### Claim 26 (depends on 1)

The compound of claim 1, wherein n is 0, 1 or 2.

### Claim 27

A compound selected from the group consisting of
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-1-phenylethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N-isopropyl-1-oxoisoindoline-5-carboxamide;
N—((S)-1-cyclopentylethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((S)-1-cyclohexylethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((S)-1-cyclopropylethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-1-phenylpropyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-1-p-tolylethyl)isoindoline-5-carboxamide;
N—((S)-1-(4-chlorophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((S)-1-cyclobutylethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-1-(pyridin-2-yl)ethyl)isoindoline-5-carboxamide;
N—((S)-1-(3-cyanophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-1-(4-methoxyphenyl)ethyl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-1-(3-methoxyphenyl)ethyl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-1-(2-methoxyphenyl)ethyl)-1-oxoisoindoline-5-carboxamide;
N—((S)-1-(3-chlorophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-1-(4-fluorophenyl)ethyl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-1-(3-fluorophenyl)ethyl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-1-(2-fluorophenyl)ethyl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-1-(pyridin-3-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-1-o-tolylethyl)isoindoline-5-carboxamide;
N—((S)-1-(2-chlorophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-cyclohexylethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-cyclohexyl-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-phenylethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-3,3,3-trifluoro-1-phenylpropyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-1-(tetrahydro-2H-pyran-4-yl)ethyl)isoindoline-5-carboxamide;
N—((S)-1-cyclohexyl-2-methylpropyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-3-methylbutan-2-yl)-1-oxoisoindoline-5-carboxamide;
N—((S)-1-cyclohexyl-3,3,3-trifluoropropyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((S)-3,3-dimethylbutan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-1,1,1-trifluoro-3-methylbutan-2-yl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-1,1,1-trifluoro-3,3-dimethylbutan-2-yl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-methoxyphenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(tetrahydro-2H-pyran-4-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-fluorophenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-methoxyphenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(pyridin-4-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-(trifluoromethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-(trifluoromethoxy)phenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(4-chlorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-chlorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-(trifluoromethoxy)phenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(4,4-difluorocyclohexyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(4,4-dimethylcyclohexyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-(trifluoromethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(pyridin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-fluorophenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(2-chlorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((S)-1-(2,4-difluorophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-(trifluoromethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N-((1R)-2,2,2-trifluoro-1-(spiro[3.5]nonan-7-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(pyridin-3-yl)ethyl)isoindoline-5-carboxamide;
N—((S)-1-(4-chloro-2-fluorophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-((1r,4R)-4-hydroxycyclohexyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(bicyclo[1.1.1]pentan-1-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-(trifluoromethoxy)phenyl)ethyl)isoindoline-5-carboxamide;
N—((S)-1-(2-chloro-4-fluorophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-((R)-2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-phenylethyl)isoindoline-5-carboxamide;
2-((S)-2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-phenylethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-((1s,4S)-4-hydroxycyclohexyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(4-cyanophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-cyanophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(1-methyl-1H-pyrazol-3-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(pyrimidin-5-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-fluoro-2-methoxyphenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((R)-1,1,1,4,4,4-hexafluoro-3,3-dimethylbutan-2-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(1-methyl-1H-pyrazol-5-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(1-methyl-1H-pyrazol-4-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N-((1R)-2,2,2-trifluoro-1-(4-(trifluoromethyl)cyclohexyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(1-methylcyclobutyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(1-(trifluoromethyl)cyclopropyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(5-fluoropyridin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-fluoro-2-(trifluoromethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(1-methylcyclopropyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(4-chloro-2-fluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(2,4-difluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(1-methylpiperidin-4-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(pyrazin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(1-methylcylopentyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-phenylethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-N—((S)-1-phenylethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-fluoro-2-(trifluoromethoxy)phenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-3-cyano-1,1,1-trifluoro-3-methylbutan-2-yl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-(trifluoromethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-phenylethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-(trifluoromethyl)phenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(4-chlorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(4-chlorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-methyloxetan-3-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-1,1,1-trifluoro-4-hydroxy-3,3-dimethylbutan-2-yl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-(trifluoromethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-(trifluoromethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-fluorophenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-fluorophenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-hydroxyphenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-isopropoxyphenyl)ethyl)isoindoline-5-carboxamide;
2-((S)-2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)isoindoline-5-carboxamide;
2-((R)-2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(2,4-difluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-chloropyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-chlorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-fluorophenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(5-chloropyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-fluoropyridin-2-yl)ethyl)isoindoline-5-carboxamide;
N—((R)-2,2-difluoro-1-(4-fluorophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-2,2-difluoro-1-(4-fluorophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(2-chlorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(5-fluoropyridin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-(trifluoromethyl)pyridin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-fluoropyridin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-1-phenylpropyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-(trifluoromethyl)pyridin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-(trifluoromethoxy)phenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-cyclohexyl-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-cyclopropoxyphenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-3,3,3-trifluoro-1-(4-fluorophenyl)propyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((R)-2-methyl-1-phenylpropyl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(6-(trifluoromethyl)pyridin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(5-(trifluoromethyl)pyridin-2-yl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(5-chloro-3-fluoropyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-o-tolylethyl)isoindoline-5-carboxamide;
N—((S)-1-(4-chlorophenyl)-3,3,3-trifluoropropyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(4-cyclopropoxyphenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(2-cyanophenyl)ethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-cyclopentylethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3,5-difluoropyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-m-tolylethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-(trifluoromethoxy)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-(trifluoromethoxy)phenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-cyclopentyl-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(bicyclo[1.1.1]pentan-1-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-chloropyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-(morpholinomethyl)phenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(4-((dimethylamino)methyl)phenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-(morpholinomethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((R)-2,2,2-trifluoro-1-p-tolylethyl)isoindoline-5-carboxamide;
N—((R)-1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-N—((S)-3,3,3-trifluoro-1-(3-fluorophenyl)propyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-phenoxyphenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(4-cyclopropoxyphenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((S)-1-(4-chlorophenyl)-3,3,3-trifluoropropyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-((dimethylamino)methyl)phenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(2-chloro-6-fluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(2-chloro-3-fluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
4-chloro-2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-2-methyl-1-phenylpropyl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-(morpholinomethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-((1r,4R)-4-hydroxy-4-methylcyclohexyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(2-cyclopropoxyphenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-phenoxyphenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-phenoxyphenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(2-chloro-5-fluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(2-cyclopropoxyphenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-3,3,3-trifluoro-1-(3-fluorophenyl)propyl)isoindoline-5-carboxamide;
N—((R)-1-(2,4-dichlorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(2,4-dichlorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-(2-hydroxypropan-2-yl)bicyclo[1.1.1]pentan-1-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N-((1R)-2,2,2-trifluoro-1-(spiro[2.5]octan-6-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-1-(2-fluorophenyl)-2-methylpropyl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-((1s,4S)-4-hydroxy-4-methylcyclohexyl)ethyl)isoindoline-5-carboxamide;
N—((S)-1-(2-chlorophenyl)-2-methylpropyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-N—((S)-1-(4-fluorophenyl)-2-methylpropyl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-chloropyridin-2-yl)-2-methylpropyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((S)-1-(3-chloropyridin-2-yl)-2-methylpropyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-chloropyridin-2-yl)-2,2,2-trifluoroethyl)-2-((S)-2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N-(2,2-difluoro-1-(4-fluorophenyl)propyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-chloro-5-fluoropyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N-(2,2,2-trifluoro-1-(2-hydroxyspiro[3.5]nonan-7-yl)ethyl)isoindoline-5-carboxamide;
N—((S)-1-(4-chlorophenyl)-2-methylpropyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3,5-dichloropyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N-((1R)-1-(4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-(pyrrolidin-1-ylmethyl)phenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N-(2,2,2-trifluoro-1-(2-hydroxyspiro[3.5]nonan-7-yl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(3-chloropyridin-2-yl)-2,2,2-trifluoroethyl)-2-((R)-2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-chloro-5-fluoropyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3,5-dichloropyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-((4-methylpiperazin-1-yl)methyl)phenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(4-((dimethylamino)methyl)phenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-3,3,3-trifluoro-1-phenylpropyl)isoindoline-5-carboxamide;
N—((R)-1-(4-((3,3-difluoroazetidin-1-yl)methyl)phenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(4-(azetidin-1-ylmethyl)phenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-3,3,3-trifluoro-1-(3-fluorophenyl)propyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-3,3,3-trifluoro-1-(4-fluorophenyl)propyl)isoindoline-5-carboxamide;
N—((R)-1-(2-((dimethylamino)methyl)phenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(5-chloro-3-fluoropyridin-2-yl)-2,2,2-trifluoroethyl)-2-((S)-2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(3-chlorophenyl)-3,3,3-trifluoropropyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-3,3,3-trifluoro-1-(2-fluorophenyl)propyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-3,3,3-trifluoro-1-o-tolylpropyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((S)-2,2,2-trifluoro-1-(2-fluorophenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(2-chloro-4-((dimethylamino)methyl)phenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-methylpyridin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-methoxypyridin-2-yl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-morpholinophenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(3-chloro-5-((dimethylamino)methyl)pyridin-2-yl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
N—((R)-1-(2-chloro-4,6-difluorophenyl)-2,2,2-trifluoroethyl)-2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-morpholinophenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-morpholinophenyl)ethyl)isoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(2-(4-methylpiperazin-1-yl)phenyl)ethyl)isoindoline-5-carboxamide;
N—((R)-1-(3,5-dichloropyridin-2-yl)-2,2,2-trifluoroethyl)-2-((S)-2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxamide;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(4-(4-methylpiperazin-1-yl)phenyl)ethyl)isoindoline-5-carboxamide and;
2-(2,6-dioxopiperidin-3-yl)-1-oxo-N—((R)-2,2,2-trifluoro-1-(3-(4-methylpiperazin-1-yl)phenyl)ethyl)isoindoline-5-carboxamide;
or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.

### Claim 28 (depends on 1)

A pharmaceutical composition comprising an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, and a pharmaceutically acceptable carrier, excipient or vehicle.

### Claim 29 (depends on 1)

A method for treating acute myeloid leukemia, the method comprising administering to a subject in need thereof an effective amount of a compound of claim 1.

### Claim 30 (depends on 28)

A method for treating acute myeloid leukemia, the method comprising administering to a subject in need thereof an effective amount of the pharmaceutical composition of claim 28.

### Claim 31 (depends on 29)

The method of claim 29, wherein the acute myeloid leukemia is newly diagnosed acute myeloid leukemia.

### Claim 32 (depends on 31)

The method of claim 31, wherein the acute myeloid leukemia is relapsed, refractory or resistant to conventional therapy.

### Claim 33 (depends on 1)

A method for reducing CK1α protein levels, the method comprising contacting a cell with an effective amount of a compound of claim 1.

### Claim 34 (depends on 33)

The method of claim 33, wherein the cell is in a subject.

### Claim 35 (depends on 1)

A method for reducing CK1α protein levels in a cell ex vivo or in vitro, the method comprising contacting a cell with an effective amount of a compound of claim 1.