# US 11,306,081 B2 · Phenylacetamides as inhibitors of rock

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- Number: US 11,306,081 B2
- Document ID: US11306081B2
- Status: Granted
- Kind: B2
- Application number: 16/629,736
- Filed: 2018-07-11
- Published: 2021-05-20
- Granted: 2022-04-19
- Earliest claimed: 2017-07-12
- Assignees: Bristol-Myers Squibb Company
- Applicants: Bristol-Myers Squibb Company
- Inventors: Michael J. Orwat; Donald J. P. Pinto
- Web page: https://patentgrep.com/patent/US11306081B2

## CPC

- C07D 417/14: containing three or more hetero rings
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 35/00: Antineoplastic agents
- A61P 37/00: Drugs for immunological or allergic disorders
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 405/14: containing three or more hetero rings
- C07D 413/12: linked by a chain containing hetero atoms as chain links
- C07D 417/12: linked by a chain containing hetero atoms as chain links
- C07D 471/04: Ortho-condensed systems
- C07D 513/04: Ortho-condensed systems
- C07F 9/65583: {each of the hetero rings containing nitrogen as ring hetero atom}
- C07F 9/6561: containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

The present invention provides compounds of Formula (I): Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

## Claims

### Claim 1

A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein
A1, at each occurrence, is independently selected from CR3 and N; provided that A1 is not all CR3 and that no more than two A1 variables are N;
R1 is NR5R5;
R2, at each occurrence, is independently selected from halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, —OH, —CH2OH, —OCH2F, —OCHF2, —OCF3, CN, —NH2, —NH(C1-4 alkyl), —N(C1-4 alkyl)2, —CO2H, —CH2CO2H, —CO2(C1-4 alkyl), —CO(C1-4 alkyl), —CH2NH2, —CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, —OCH2CO2H, —NHCO(C1-4 alkyl), —NHCO2(C1-4 alkyl), —NHSO2(C1-4 alkyl), —SO2NH2, —C(═NH)NH2, carbocycle, and heterocycle, wherein said alkyl, alkoxy, alkylthio, haloalkyl, carbocycle, and heterocycle are substituted with 0-4 R9;
R3, at each occurrence, is independently selected from H, halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, —CH2OH, —OCH2F, —OCHF2, —OCF3, CN, —NH2, —NH(C1-4 alkyl), —N(C1-4 alkyl)2, —CO2H, —CH2CO2H, —CO2(C1-4 alkyl), —CO(C1-4 alkyl), —CH2NH2, —CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, —OCH2CO2H, —NHCO(C1-4 alkyl), —NHCO2(C1-4 alkyl), —NHSO2(C1-4 alkyl), —SO2NH2, —C(═NH)NH2, carbocycle, and heterocycle, wherein said alkyl, alkoxy, alkylthio, haloalkyl, carbocycle, and heterocycle are substituted with 0-4 R9;
R4, at each occurrence, is independently selected from H and C1-4 alkyl;
R5, at each occurrence, is independently selected from H, —(CR6R6)n—C3-10 carbocycle, and —(CR6R6)n— 4-15 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said alkyl, carbocycle and heterocycle are substituted with 1-4 R7;
alternatively, R5 and R5 are taken together with the nitrogen atom to which they are attached to form 4- to 15-membered heterocycle substituted with 1-4 R7;
R6, at each occurrence, is independently selected from H and C1-4 alkyl;
R7, at each occurrence, is independently selected from H, ═O, NO2, halogen, C1-4 alkyl, C1-4 alkoxy, CN, OH, CF3, —(CH2)n—CO2H, —(CH2)n—CO2(C1-4 alkyl), —(CH2)n—NR8R8, —NHCO(C1-4 alkyl), —NHCOCF3, —NHCO2(C1-4 alkyl), —NHCO2(CH2)2O(C1-4 alkyl), —NHCO2(CH2)3O(C1-4 alkyl), —NHCO2(CH2)2OH, —NHCO2(CH2)2NH2, —NHCO2(CH2)2N(C1-4 alkyl)2, —NHCO2CH2CO2H, —CH2NHCO2(C1-4 alkyl), —NHC(O)NR8R8, —NHSO2(C1-4 alkyl), —SO2NH2, —SO2NH(C1-4 alkyl), —SO2N(C1-4 alkyl)2, —SO2NH(CH2)2OH, —SO2NH(CH2)2O(C1-4 alkyl), —(CH2)n—CONR8R8, —O(CH2)n-carbocycle, —O(CH2)n-heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH2)n-carbocycle, and —(CH2)n-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said alkyl, alkenyl, alkynyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R9;
R8, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, —(CH2)n—C(O)C1-4alkyl, —(CH2)n—C(O)carbocycle, —(CH2)n—C(O)heterocycle, —(CH2)n—C(O)NRaRa, —(CH2)n—C(O)O-alkyl, —(CH2)n—C(O)O-carbocycle, —(CH2)n—C(O)O-heterocycle, —(CH2)n—SO2alkyl, —(CH2)n SO2carbocycle, —(CH2)n—SO2heterocycle, —(CH2)n—SO2NRaRa, —(CH2)n-carbocycle, and —(CH2)n-heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R9;
alternatively, R8 and R8 are taken together with the nitrogen atom to which they are attached to form 4- to 10-membered heterocycle substituted with 0-4 R9;
R9, at each occurrence, is independently selected from halogen, OH, NO2, CHF2, CF3, C1-4 alkyl, C1-4 alkoxy, CH2OH, CO(C1-4 alkyl), CO2H, CO2(C1-4 alkyl), —(CH2)nNRaRa, —(CH2)nCONRaRa, —O(CH2)ncarbocycle, —O(CH2)nheterocycle, —O(CH2)nNRaRa, —(CR10R10)n— 4-10 membered heterocycle, wherein said alkyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 Rb;
R10 is selected from H and C1-4 alkyl;
Ra, at each occurrence, is independently selected from H, C1-4 alkyl, —(CH2)nOH, CO(C1-4 alkyl), COCF3, CO2(C1-4 alkyl), —CONH2, —CONH—C1-4 alkylene-CO2(C1-4 alkyl), C1-4 alkylene-CO2(C1-4 alkyl), Rc, CO2Rc, and CONHRc; alternatively, Ra and Ra are taken together with the nitrogen atom to which they are attached to form 4- to 10-membered heterocycle, wherein said alkyl, alkylene, and heterocycle are substituted with 0-4 Rb;
Rb, at each occurrence, is independently selected from ═O, OH, halogen, C1-4 alkyl, C1-4 alkoxy, OCF3, NH2, NO2, N(C1-4 alkyl)2, CO(C1-4 alkyl), CO(C1-4 haloalkyl), CO2(C1-4 alkyl), CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, —CONH—C1-4 alkylene-O(C1-4 alkyl), —CONH—C1-4 alkylene-N(C1-4 alkyl)2, —CONH—C1-4 alkylene-N(C1-4 alkyl)2, —C1-4 alkylene-O—P(O)(OH)2, —NHCO2(C1-4 alkyl), —Rc, CORc, CO2Rc, and CONHRc;
Rc, at each occurrence, is independently selected from —(CH2)n—C3-6 cycloalkyl, —(CH2)n-phenyl, and —(CH2)n-5- to 6-membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C1-4 alkyl), O, and S(O)p; wherein each ring moiety is substituted with 0-2 Rd;
Rd, at each occurrence, is independently selected from ═O, halogen, —OH, C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, C1-4 alkoxy, and —NHCO(C1-4 alkyl), and heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C1-4 alkyl), O, and S(O)p;
n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and
p, at each occurrence, is independently selected from 0, 1, and 2.

### Claim 2 (depends on 1)

The compound of claim 1, having Formula (II):
or a pharmaceutically acceptable salt thereof, wherein
R2 is independently selected from halogen and C1-6 alkyl;
R5 is a 4-15 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said heterocycle is substituted with 1-4 R7;
R7, at each occurrence, is independently selected from H, ═O, NO2, halogen, C1-4 alkyl, C1-4 alkoxy, CN, OH, CF3, —(CH2)n—CO2H, —(CH2)n—CO2(C1-4 alkyl), —(CH2)n—NR8R8, —NHCO(C1-4 alkyl), —NHCOCF3, —NHCO2(C1-4 alkyl), —NHCO2(CH2)2O(C1-4 alkyl), —NHCO2(CH2)3O(C1-4 alkyl), —NHCO2(CH2)2OH, —NHCO2(CH2)2NH2, —NHCO2(CH2)2N(C1-4 alkyl)2, —NHCO2CH2CO2H, —CH2NHCO2(C1-4 alkyl), —NHC(O)NR8R8, —NHSO2(C1-4 alkyl), —SO2NH2, —SO2NH(C1-4 alkyl), —SO2N(C1-4 alkyl)2, —SO2NH(CH2)2OH, —SO2NH(CH2)2O(C1-4 alkyl), —(CH2)n—CONR8R8, —O(CH2)n-carbocycle, —O(CH2)n-heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH2)n-carbocycle, and —(CH2)n-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said alkyl, alkenyl, alkynyl, alkoxy, carbocycle, and heterocycle are substituted with 0-4 R9;
R8, at each occurrence, is independently selected from H, C1-4 alkyl, C(O)C1-4alkyl, —(CH2)n C(O)NRaRa, C(O)O-alkyl, SO2alkyl, SO2NRaRa, —(CH2)n-carbocycle, and —(CH2)n-heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R9;
R9, at each occurrence, is independently selected from halogen, OH, NO2, CHF2, CF3, C1-4 alkyl, C1-4 alkoxy, CH2OH, CO2H, CO2(C1-4 alkyl), CONH2, —(CH2)nNRaRa, —(CH2)nCONRaRa, —O(CH2)nheterocycle, —O(CH2)(2-4)NRaRa, —(CH2)n— 4-10 membered heterocycle, wherein said alkyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 Rb;
Ra, at each occurrence, is independently selected from H, C1-4 alkyl, —(CH2)nOH, CO(C1-4 alkyl), COCF3, CO2(C1-4 alkyl), —CONH2, —CONH—C1-4 alkylene-CO2(C1-4 alkyl), C1-4 alkylene-CO2(C1-4 alkyl), Rc, CO2Rc, and CONHRc; alternatively, Ra and Ra are taken together with the nitrogen atom to which they are attached to form 4- to 10-membered heterocycle, wherein said alkyl, alkylene, and heterocycle are substituted with 0-4 Rb;
Rb, at each occurrence, is independently selected from ═O, halogen, C1-4 alkyl, C1-4 alkoxy, OCF3, NH2, NO2, N(C1-4 alkyl)2, CO(C1-4 alkyl), CO(C1-4 haloalkyl), CO2(C1-4 alkyl), CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, —CONH—C1-4 alkylene-O(C1-4 alkyl), —CONH—C1-4 alkylene-N(C1-4 alkyl)2, —CONH—C1-4 alkylene-N(C1-4 alkyl)2, —C1-4 alkylene-O—P(O)(OH)2, —NHCO2(C1-4 alkyl), —Rc, CORc, CO2Rc, and CONHRc;
Rc, at each occurrence, is independently selected from —(CH2)n—C3-6 cycloalkyl, —(CH2)n-phenyl, and —(CH2)n-5- to 6-membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C1-4 alkyl), O, and S(O)p; wherein each ring moiety is substituted with 0-2 Rd;
Rd, at each occurrence, is independently selected from ═O, halogen, —OH, C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, C1-4 alkoxy, and —NHCO(C1-4 alkyl), and heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C1-4 alkyl), O, and S(O)p;
n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4;
p, at each occurrence, is independently selected from 0, 1, and 2.

### Claim 3 (depends on 2)

The compound of claim 2, or a pharmaceutically acceptable salt thereof, wherein
R2 is independently selected from F, Cl, and Br;
R5 is selected from
R7, at each occurrence, is independently selected from H, ═O, halogen, C1-4 alkyl, C1-4 alkoxy, CN, OH, CF3, —(CH2)n—CO2H, —(CH2)n—CO2(C1-4 alkyl), —(CH2)n—NR8R8, —NHCO(C1-4 alkyl), —NHCOCF3, —NHCO2(C1-4 alkyl), —NHCO2(CH2)2O(C1-4 alkyl), —NHCO2(CH2)3O(C1-4 alkyl), —NHCO2(CH2)2OH, —NHCO2(CH2)2NH2, —NHCO2(CH2)2N(C1-4 alkyl)2, —NHCO2CH2CO2H, —CH2NHCO2(C1-4 alkyl), —NHC(O)NR8R8, —NHSO2(C1-4 alkyl), —SO2NH2, —SO2NH(C1-4 alkyl), —SO2N(C1-4 alkyl)2, —SO2NH(CH2)2OH, —SO2NH(CH2)2O(C1-4 alkyl), —(CH2)n—CONR8R8, —O(CH2)n-carbocycle, —O(CH2)n-heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH2)n-carbocycle, and —(CH2)n-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said alkyl, alkenyl, alkynyl, alkoxy, carbocycle, and heterocycle are substituted with 0-4 R9;
R8, at each occurrence, is independently selected from H, C1-4 alkyl, —(CH2)n-carbocycle, and —(CH2)n-heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R9; and
R9, at each occurrence, is independently selected from halogen, OH, NO2, CHF2, CF3, C1-4 alkyl, C1-4 alkoxy, CH2OH, CO2H, CO2(C1-4 alkyl), CONH2, —(CH2)nNH2, —(CH2)nCONH2, —O(CH2)nheterocycle, —O(CH2)(2-4)NH2, —(CH2)n-4-10 membered heterocycle.

### Claim 4 (depends on 3)

The compound of claim 3, or a pharmaceutically acceptable salt thereof, wherein
R2 is independently selected from F and Cl;
R5 is selected from
R7, at each occurrence, is independently selected from H, halogen, C1-4 alkyl, C1-4 alkoxy, a carbocycle, and a heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said alkyl, alkenyl, alkynyl, alkoxy, carbocycle, and heterocycle are substituted with 0-4 R9;
R8, at each occurrence, is independently selected from H, C1-4 alkyl, and —(CH2)n—C3-6cycloalkyl; and
R9, at each occurrence, is independently selected from halogen, OH, CHF2, CF3, C1-4 alkyl, C1-4 alkoxy, CH2OH, CO2H, CO2(C1-4 alkyl), and CONH2.

### Claim 5 (depends on 4)

The compound of claim 4, or a pharmaceutically acceptable salt thereof, wherein R7, at each occurrence, is independently selected from H, F, Cl, Br, Me, Et, OMe, OEt, OCH2C(CH2)2OH,
R9, at each occurrence, is independently selected from F, Cl, Br, OH, CHF2, CF3, C1-4 alkyl, and C1-4 alkoxy.

### Claim 6 (depends on 1)

The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein
R5 and R5 are taken together with the nitrogen atom to which they are attached to form
and
R7 is selected from H, CN, C1-4 alkyl substituted with 0-4 R9, C1-4 alkoxy substituted with 0-4 R9; and
R9 is selected from halogen, OH, C3-6 cycloalkyl, phenyl, and heterocycle.

### Claim 7

A compound having Formula (III):
or a pharmaceutically acceptable salt thereof, wherein
R2 is selected from F, Cl, Br, and OC1-4 alkyl;
R4 is selected from H and C1-4 alkyl;
R5 is selected from
R7, at each occurrence, is independently selected from H, ═O, NO2, halogen, C1-4 alkyl, C1-4 alkoxy, CN, OH, CF3, —(CH2)n—CO(C1-4 alkyl), —(CH2)n—CO2H, —(CH2)n—CO2(C1-4 alkyl), —(CH2)n—NR8R8, —NHCO(C1-4 alkyl), —NHCOCF3, —NHCO2(C1-4 alkyl), —NHCO2(CH2)2O(C1-4 alkyl), —NHCO2(CH2)3O(C1-4 alkyl), —NHCO2(CH2)2OH, —NHCO2(CH2)2NH2, —NHCO2(CH2)2N(C1-4 alkyl)2, —NHCO2CH2CO2H, —CH2NHCO2(C1-4 alkyl), —NHC(O)NR8R8, —NHSO2(C1-4 alkyl), —P(═O)(C1-3 alkyl)2, —SO2C1-4 alkyl, —SO2NH2, —SO2NH(C1-4 alkyl), —SO2N(C1-4 alkyl)2, —SO2NH(CH2)2OH, —SO2NH(CH2)2O(C1-4 alkyl), —(CH2)n—CONR8R8, —O(CH2)n-carbocycle, —O(CH2)n-heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —CO-carbocycle, —CO-heterocycle, —(CH2)n-carbocycle, and —(CH2)n-heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR8, O, and S(O)p, wherein said alkyl, alkenyl, alkynyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R9;
R8, at each occurrence, is independently selected from H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, —(CH2)n—C(O)C1-4alkyl, —(CH2)n—C(O)carbocycle, —(CH2)n—C(O)heterocycle, —(CH2)n—C(O)NRaRa, —(CH2)n—C(O)O-alkyl, —(CH2)n—C(O)O-carbocycle, —(CH2)n—C(O)O-heterocycle, —(CH2)n—SO2alkyl, —(CH2)n SO2carbocycle, —(CH2)n—SO2heterocycle, —(CH2)n—SO2NRaRa, —(CH2)n-carbocycle, and —(CH2)n-heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R9;
alternatively, R8 and R8 are taken together with the nitrogen atom to which they are attached to form 4- to 10-membered heterocycle substituted with 0-4 R9;
R9, at each occurrence, is independently selected from halogen, OH, NO2, CHF2, CN, CF3, C1-4 alkyl, C1-4 alkoxy, CH2OH, CO(C1-4 alkyl), CO2H, CO2(C1-4 alkyl), —(CH2)nNRaRa, —(CH2)nCONRaRa, —O(CH2)ncarbocycle, —O(CH2)nheterocycle, —O(CH2)nNRaRa, NRaCO2(C1-4 alkyl), S(O)pC1-4 alkyl, —(CR10R10)n-carbocycle, —(CR10R10)n— 4-10 membered heterocycle, wherein said alkyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 Rb;
R10 is selected from H and C1-4 alkyl;
Ra, at each occurrence, is independently selected from H, C1-4 alkyl, —(CH2)nOH, CO(C1-4 alkyl), COCF3, CO2(C1-4 alkyl), —CONH2, —CONH—C1-4 alkylene-CO2(C1-4 alkyl), C1-4 alkylene-CO2(C1-4 alkyl), Rc, CO2Rc, and CONHRc; alternatively, Ra and Ra are taken together with the nitrogen atom to which they are attached to form 4- to 10-membered heterocycle, wherein said alkyl, alkylene, and heterocycle are substituted with 0-4 Rb;
Rb, at each occurrence, is independently selected from ═O, OH, halogen, C1-4 alkyl, C1-4 alkoxy, OCF3, NH2, NO2, N(C1-4 alkyl)2, CO(C1-4 alkyl), CO(C1-4 haloalkyl), CO2(C1-4 alkyl), CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, —CONH—C1-4 alkylene-O(C1-4 alkyl), —CONH—C1-4 alkylene-N(C1-4 alkyl)2, —CONH—C1-4 alkylene-N(C1-4 alkyl)2, —C1-4 alkylene-O—P(O)(OH)2, —NHCO2(C1-4 alkyl), —Rc, CORc, CO2Rc, and CONHRc;
Rc, at each occurrence, is independently selected from —(CH2)n—C3-6 cycloalkyl, —(CH2)n-phenyl, and —(CH2)n-5- to 6-membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C1-4 alkyl), O, and S(O)p; wherein each ring moiety is substituted with 0-2 Rd;
Rd, at each occurrence, is independently selected from ═O, halogen, —OH, C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, C1-4 alkoxy, and —NHCO(C1-4 alkyl), and heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C1-4 alkyl), O, and S(O)p;
n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and
p, at each occurrence, is independently selected from 0, 1, and 2.

### Claim 8 (depends on 7)

The compound of claim 7, or a pharmaceutically acceptable salt thereof, wherein
R2 is selected from F, Cl, and OCH3;
R5 is selected from
R7 is selected from H, C1-3alkyl substituted with halogen,
R8 is selected from H and C1-3alkyl optionally substituted with halogen;
R9 is selected from F, Cl, CN, C1-4 alkyl substituted with 0-2 Rb, C1-3 alkoxy, C3-6 cycloalkyl, NHCOOC1-4 alkyl, SO2C1-3 alkyl, and
and
Rb, at each occurrence, is independently selected from OH and halogen.

### Claim 9 (depends on 7)

The compound of claim 7, or a pharmaceutically acceptable salt thereof, wherein
R2 is independently selected from F, Cl, and OCH3;
R5 is selected from
R7 is selected from H, F, Cl, Br, C1-3 alkyl substituted with 0-4 R9, C1-3 alkoxy substituted with 0-4 R9, CN, CO2C1-4 alkyl, P(═O)(C1-3 alkyl)2, SO2C1-4 alkyl,
R8 is selected from H and C1-3 alkyl substituted with 0-4 R9;
R9 is selected from halogen, OH, CN, C1-3 alkyl substituted with 0-4 Rb, C1-3 alkoxy substituted with 0-4 Rb, CO2(C1-4 alkyl), CONH2, NHCO2(C1-3 alkyl), C3-6 cycloalkyl, phenyl, and heterocycle; and
Rb, at each occurrence, is independently selected from OH and halogen.

### Claim 10 (depends on 7)

The compound of claim 7, or a pharmaceutically acceptable salt thereof, wherein
R2 is independently selected from F, Cl, and OCH3;
R5 is selected from
R7 is selected from H, CN, C1-3 alkyl substituted with 0-4 R9, C1-3 alkoxy substituted with 0-4 R9, CO2C1-4 alkyl, CONH2, P(═O)(C1-3 alkyl)2, SO2C1-3 alkyl,
R8 is selected from H and C1-3 alkyl substituted with 0-4 R9;
R9 is selected from halogen, OH, CN, C1-3 alkyl substituted with 0-4 Rb; C1-3 alkoxy substituted with 0-4 Rb, CO2(C1-4 alkyl), CONH2, NHCO2(C1-3 alkyl), C3-6 cycloalkyl, phenyl, and heterocycle; and
Rb, at each occurrence, is independently selected from OH and halogen.

### Claim 11 (depends on 7)

The compound of claim 7 or a pharmaceutically acceptable salt thereof, wherein
R2 is selected from F, Cl, and OCH3;
R5 is
R7 is selected from H, F, Cl, Br, CN, C1-3 alkyl substituted with 0-4 R9, C1-3 alkoxy substituted with 0-4 R9, CO2C1-4 alkyl, CONH2, P(═O)(C1-3 alkyl)2, SO2C1-3 alkyl, and
R8 is selected from H and C1-3 alkyl substituted with 0-4 R9;
R9 is selected from halogen, OH, CN, C1-3 alkyl substituted with 0-4 Rb; C1-3 alkoxy substituted with 0-4 Rb, CO2(C1-4 alkyl), CONH2, NHCO2(C1-3 alkyl), C3-6 cycloalkyl, phenyl, and heterocycle; and
Rb, at each occurrence, is independently selected from OH and halogen.

### Claim 12 (depends on 1)

A pharmaceutical composition comprising one or more compounds according to claim 1 and a pharmaceutically acceptable carrier or diluent.

### Claim 13 (depends on 1)

A compound according to claim 1, wherein the compound is selected from
2-(2-fluoro-4-(2-((7-methoxy-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-methoxybenzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy) nicotinamide;
2-(2-fluoro-4-(2-((5-(2-hydroxy-2-methylpropoxy)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-(1,3-dimethyl-1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((5-(3,5-dimethyl-1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide
2-(2-chloro-4-(2-((1-(cyclopropylmethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((7-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((6-bromoimidazo[1,2-a]pyridin-2-yl)amino)-2-oxoethyl)-2-chlorophenoxy)nicotinamide;
2-(2-chloro-4-(2-((1-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((5-(pyrazin-2-yl)-1,3,4-thiadiazol-2yl)amino)ethyl)phenoxy) nicotinamide;
2-(2-fluoro-4-(2-((4-methyl-5-(pyridin-2-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((4-(5-fluoropyridin-2-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-methyl-4-phenylthiazol-2-yl)amino)-2-oxoethyl)phenoxy) nicotinamide;
2-(2-fluoro-4-(2-((4-(6-fluoropyridin-2-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-(benzo[d]thiazol-2-ylamino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-((4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((4-(2-oxo-1,2-dihydropyridin-4-yl)thiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
methyl (4-(2-(2-(4-((3-carbamoylpyridin-2-yl)oxy)-3-fluorophenyl)acetamido)-5-methylthiazol-4-yl)pyridin-2-yl)carbamate;
2-(2-fluoro-4-(2-((5-methyl-4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((4-(1-(difluoromethyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-chloro-4-(2-((5-methyl-4-(6-methylpyridin-2-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((4-cyclobutyl-5-(pyridin-2-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((5-(2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-(3-cyclopropyl-1-methyl-1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((5-(1,3,4-trimethyl-1H-pyrazol-5-yl)benzo[d]thiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-((5-(1,3-dimethyl-1H-pyrazol-5-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((5-(1-(difluoromethyl)-1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-(1-methyl-1H-pyrazol-5-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((5-(3-(trifluoromethyl)-1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-(1-methyl-1H-pyrazol-3-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-(1-(methyl-d3)-1H-pyrazol-3-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-(1-methyl-1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-(1-methyl-1H-pyrazol-4-yl)-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-4-(2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((4-(2-methoxypyrimidin-5-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-4-(pyrimidin-5-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((4-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((4-(6-methoxypyridin-2-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-4-(pyridin-4-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((4-(6-cyanopyridin-2-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((4-cyclopropyl-5-methylthiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-4-(4-(methylsulfonyl)phenyl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((4-(4-(isopropylsulfonyl)phenyl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-(benzo[d]thiazol-2-ylamino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((4-(3-chloro-4-methylphenyl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((4-(3,4-dimethoxyphenyl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-oxo-2-((4-phenylthiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-((7-methoxy-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-(benzo[d]oxazol-2-ylamino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-methyl-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-(7-cyano-5-methoxyindolin-1-yl)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-oxo-2-((5-phenyl-1,3,4-thiadiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-(5-(benzyloxy)indolin-1-yl)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-methyl-4-phenylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-oxo-2-((4-(2-oxo-2H-chromen-5-yl)thiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-oxo-2-((4-(3-(trifluoromethoxy)phenyl)thiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-((4-(3-cyanophenyl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((4-(3-fluorophenyl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
methyl 2-(2-(4-((3-carbamoylpyridin-2-yl)oxy)phenyl)acetamido)benzo[d]thiazole-5-carboxylate;
2-(2-(4-((3-carbamoylpyridin-2-yl)oxy)phenyl)acetamido)benzo[d]thiazole-6-carboxamide;
2-(4-(2-((6-methoxybenzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-methyl-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-oxo-2-((5-(propylsulfonyl)-1H-benzo[d]imidazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
methyl 2-(2-(4-((3-carbamoylpyridin-2-yl)oxy)phenyl)acetamido)benzo[d]thiazole-6-carboxylate;
2-(4-(2-((5-cyano-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-benzoyl-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((7-chloro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
methyl 2-(2-(4-((3-carbamoylpyridin-2-yl)oxy)phenyl)acetamido)-1-methyl-1H-benzo[d]imidazole-5-carboxylate;
2-(4-(2-((1-methyl-1H-indazol-3-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((6-(methylsulfonyl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-oxo-2-((4-(m-tolylamino)quinazolin-6-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-((4-(4-fluorophenyl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide,
2-(4-(2-((1-benzyl-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-chlorophenoxy)nicotinamide;
2-(2-chloro-4-(2-((4-(2-fluorophenyl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((4-(6-methylimidazo[2,1-b]thiazol-5-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-4,5,6,7-tetrahydrothiazolo[4,5-c]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((4-(6-fluoropyridin-3-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-4-(1-methyl-1H-pyrazol-5-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-4-(pyridin-2-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-4-(2-methylpyrimidin-4-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-((5-cyclopropyl-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((5-(3,4-dimethoxybenzyl)-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-((8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-((4,5-dimethylthiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide,
2-(2-fluoro-4-(2-oxo-2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl)amino)ethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((1-(5-(trifluoromethyl)pyridin-2-yl)-1H-pyrazol-3-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-((3-cyclopropyl-1,2,4-thiadiazol-5-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-chloro-4-(2-((4-(2-fluoropyridin-3-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((4-(6-fluoropyridin-3-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((5-methyl-4-(1-methyl-1H-pyrazol-4-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((4-(6-chloropyridin-3-yl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(1-((7-methoxy-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)amino)-1-oxopropan-2-yl)phenoxy)nicotinamide;
2-(4-(2-((5-(2-hydroxy-2-methylpropoxy)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((7-(2-hydroxy-2-methylpropoxy)-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((6-(2-hydroxy-2-methylpropoxy)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((7-(2-hydroxy-2-methylpropoxy)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-chloro-4-(2-((5-(2-hydroxy-2-methylpropoxy)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((7-(2-hydroxy-2-methylpropoxy)-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-(6-(2-hydroxy-2-methylpropoxy)indolin-1-yl)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((5-methoxybenzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((7-methoxy-4,5-dihydronaphtho[1,2-d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-methoxy-4-(2-((5-methoxybenzo[d]thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((5-(2-hydroxy-2-methylpropoxy)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)-2-methoxyphenoxy)nicotinamide;
2-(2-bromo-4-(2-((7-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((1-(2,2-difluoroethyl)-5-methoxy-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-chloro-4-(2-((5-(difluoromethoxy)thiazolo[5,4-b]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((1H-indazol-3-yl)amino)-2-oxoethyl)-2-chlorophenoxy)nicotinamide;
2-(4-(2-((1-(2,2-difluoroethyl)-6-methoxy-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((7-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((7-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((5-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((8-fluoro-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((6-fluoro-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((6-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-((6,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((5,6-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(4-(2-((7-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((7-(1-(difluoromethyl)-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((7-(1,3-dimethyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-((7-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((6-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((8-(difluoromethoxy)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((6-(trifluoromethoxy)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((8-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)ethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((7-fluoro-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((7-(benzyloxy)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-6-(dimethylphosphoryl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((5-(dimethylphosphoryl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((5-(dimethylphosphoryl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((5-(dimethylphosphoryl)-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((6-(dimethylphosphoryl)imidazo[1,2-a]pyridin-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(2,2-difluoroethyl)-6-(dimethylphosphoryl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-((5-methyl-4-(6-methylpyridin-2-yl)thiazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((1-(cyclobutylmethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-fluoro-4-(2-((1-isopropyl-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-phenoxy)nicotinamide;
2-(2-fluoro-4-(2-oxo-2-((1-(3,3,3-trifluoropropyl)-1H-benzo[d]-imidazol-2-yl)-amino)ethyl)phenoxy)nicotinamide;
2-(2-fluoro-4-(2-((1-(2-methoxyethyl)-1H-benzo[d]imid-azol-2-yl)amino)-2-oxoethyl)-phenoxy)nicotinamide;
2-(2-(4-((3-carbamoylpyridin-2-yl)oxy)-3-fluorophenyl)acetamido)-1-(2-methoxyethyl)-1H-benzo[d]imidazole-5-carboxamide;
2-(2-fluoro-4-(2-((6-methoxy-1-(2-methoxyethyl)-1H-benzo[d]-imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-(4-((3-carbamoylpyridin-2-yl)oxy)-3-fluorophenyl)acetamido)-1-(2-methoxyethyl)-1H-benzo[d]-imidazole-6-carboxamide;
2-(2-fluoro-4-(2-oxo-2-((1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)amino)ethyl)-phenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-6-methoxy-1H-benzo[d]-imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-4-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-5-methoxy-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-4-methoxy-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-7-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-5-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(2,2-difluoroethyl)-6-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-6-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(4-(2-((6-(benzyloxy)-1-(cyclopropylmethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-chloro-4-(2-((1-(cyclopropylmethyl)-4-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((1-(cyclopropylmethyl)-6-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((1-(cyclopropylmethyl)-5-fluoro-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(4-(2-((1-(cyclopropylmethyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
2-(2-chloro-4-(2-((1-(cyclopropylmethyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide;
2-(2-chloro-4-(2-((1-(cyclopropylmethyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)phenoxy)nicotinamide; or
2-(4-(2-((1-(cyclopropylmethyl)-6-(2-hydroxy-2-methylpropoxy)-1H-benzo[d]imidazol-2-yl)amino)-2-oxoethyl)-2-fluorophenoxy)nicotinamide;
or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof.

### Claim 14 (depends on 1)

A method for treatment of a disorder selected from the group consisting of angina, atherosclerosis, stroke, cerebrovascular disease, heart failure, coronary artery disease, myocardial infarction, peripheral vascular disease, stenosis, vasospasm, hypertension and pulmonary hypertension, comprising administrating to a patient in need thereof a therapeutically effective amount of a compound according to claim 1.