# US 11,306,072 B2 · 5-bromo-indirubins

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- Number: US 11,306,072 B2
- Document ID: US11306072B2
- Status: Granted
- Kind: B2
- Application number: 16/790,611
- Filed: 2020-02-13
- Published: 2020-09-10
- Granted: 2022-04-19
- Earliest claimed: 2013-03-14
- Assignees: City of Hope; National and Kapodistrian University of Athens
- Applicants: City of Hope; National and Kapodistrian University of Athens
- Inventors: Richard Jove; Sangkil Nam; David Horne; Jun Xie; Alexios Leandros Skaltsounis; Marina Kritsanida; Nicolas Gaboriaud-Kolar
- Web page: https://patentgrep.com/patent/US11306072B2

## CPC

- C07D 403/14: containing three or more hetero rings
- A61K 31/404: Indoles, e.g. pindolol
- A61K 31/4439: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465)
- A61K 31/496: Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 209/40: Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
- C07D 209/48: with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- C07D 401/14: containing three or more hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.

## Claims

### Claim 1

A method of treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound
or a pharmaceutically acceptable salt thereof; and
wherein said cancer is lung cancer, breast cancer, ovarian cancer, leukemia, melanoma, pancreatic cancer, or prostate cancer.

### Claim 2 (depends on 1)

The method of claim 1, wherein said compound is in a pharmaceutical composition comprising a pharmaceutically acceptable excipient.

### Claim 3 (depends on 1)

The method of claim 1, wherein said compound is co-administered with an effective amount of an anti-cancer agent.