Heterocyclic naphthoquinones derivatives for use in the treatment of cancers including Cushing disease

A method for the treatment of cancer comprising administration to a subject in need thereof a compound of following formula (I):

• wherein:
• A is selected from the group consisting of:
• Ra and Rb each independently represent:
• when A is A1 or A3, a group of one of the following formulae:
• when A is A2, H or a group of one of the following formulae:
• provided that at least one of Ra and Rb is not H;
• RY and RZ each independently represent H, a C1-C10 linear or branched alkyl group, or a C3-C10 cycloalkyl group, or RY and RZ together form with the carbon atom to which they are attached a C3-C10 cycloalkyl group;
• X represents Cl or a group the following formula:
• RX represents a C1-C10 linear or branched alkyl group, a C3-C10 cycloalkyl group, an aryl group, or a C5-C10-membered heteroaryl;
• said C1-C10 linear or branched alkyl group, and C3-C10 cycloalkyl group being optionally substituted by at least one group selected from:
• a C3-C10 cycloalkyl group;
• a phenyl optionally substituted by at least one group selected from a C1-C10 linear or branched alkyl group, a C3-C10 cycloalkyl group, an halogen, a —ORii group, an amine of formula —NRii′Rii″, a nitrile or a nitro group;
• a —ORi group;
• or
• an amine of formula —NRi′Ri″;
• said aryl and C5-C10-membered heteroaryl being optionally substituted by at least one group selected from:
• a C1-C10 linear or branched alkyl group;
• a C3-C10 cycloalkyl group;
• a phenyl optionally substituted by at least one group selected from a C1-C10 linear or branched alkyl group, a C3-C10 cycloalkyl group, an halogen, a —ORii group, an amine of formula —NRii′Rii″, a nitrile or a nitro group;
• an halogen;
• a —ORi group;
• an amine of formula —NRi′Ri″;
• a nitrile;
• a nitro group;
• or
• a CF3 group;
• and/or said aryl and C5-C10-membered heteroaryl being substituted by two adjacent —ORi groups that form with the two C atoms bearing said —ORi groups a 1,4-dioxane ring;
• Ri and Rii each independently represent H, a C1-C10 linear or branched alkyl group, or a C3-C10 cycloalkyl group;
• Ri′ and Ri″ each independently represent H, a C1-C10 linear or branched alkyl group, or a C3-C10 cycloalkyl group, or Ri′ and Ri″ together form with the nitrogen atom to which they are attached a C4-C7 heterocycloalkyl group;
• Rii′ and Rii″ each independently represent H, a C1-C10 linear or branched alkyl group, or a C3-C10 cycloalkyl group, or Rii′ and Rii″ together form with the nitrogen atom to which they are attached a C4-C7 heterocycloalkyl group,
• said cancer being selected from the group consisting of prostate cancer, bladder cancer, breast cancer, lung cancer, colorectal cancer, pituitary adenomas and Cushing's disease.