# US 11,306,062 B2 · Forms of fedratinib dihydrochloride

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- Number: US 11,306,062 B2
- Document ID: US11306062B2
- Status: Granted
- Kind: B2
- Application number: 17/084,154
- Filed: 2020-10-29
- Published: 2021-04-29
- Granted: 2022-04-19
- Earliest claimed: 2019-10-29
- Assignees: Johnson Matthey Public Limited Company
- Applicants: Johnson Matthey Public Limited Company
- Inventors: Na Yao
- Web page: https://patentgrep.com/patent/US11306062B2

## CPC

- C07D 239/69: Benzenesulfonamido-pyrimidines
- C07D 239/48: Two nitrogen atoms
- C07B 2200/13: Crystalline forms, e.g. polymorphs
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)

## Abstract

The present disclosure relates to novel forms of fedratinib dihydrochloride (diHCl) and processes for the preparation of the various forms. The present disclosure also relates to pharmaceutical compositions comprising the novel forms of fedratinib dihydrochloride and methods for treating disease using the forms.

## Claims

### Claim 1

A fedratinib diHCl co-crystal selected from a fedratinib diHCl co-crystal with succinic acid and a fedratinib diHCl co-crystal with fumaric acid.

### Claim 2 (depends on 1)

The fedratinib diHCl co-crystal with succinic acid of claim 1 which is characterized by having at least 2 or more X-ray powder diffraction peaks selected from about 4.5, 9.2, and 15.6° 2Θ±0.2° 2Θ.

### Claim 3 (depends on 1)

The fedratinib diHCl co-crystal with succinic acid of claim 1 which is characterized by endotherms with onset temperatures at about 118 and 207° C.±2° C., as measured by differential scanning calorimetry.

### Claim 4 (depends on 1)

The fedratinib diHCl co-crystal with fumaric acid of claim 1 which is characterized by having at least 2 or more X-ray powder diffraction peaks selected from about 9.4, 11.2, and 15.8° 2Θ±0.2° 2Θ.

### Claim 5 (depends on 1)

The fedratinib diHCl co-crystal with fumaric acid of claim 1 which is characterized by endotherms with onset temperatures at about 132 and 179°±2° C., as measured by differential scanning calorimetry.