N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

A method of preparing a compound of formula A2:

• the method comprising:
• (a) deprotecting the compound of formula C2 to form the compound of formula A2;
• wherein:
• the compound of formula C2 is:
• and
• and wherein, in the compounds of formulae A2 and C2:
• R is:
• and
• R3, R4, R5, R6, and R7 are independently selected from the group consisting of H, halo, alkylsulfonyl, N-hydroxylsulfonamidyl, perhaloalkyl, nitro, aryl, cyano, alkoxy, perhaloalkoxy, alkyl, substituted aryloxy, alkylsulfanyl, alkylsulfinyl, heterocycloalkyl, substituted heterocycloalkyl, dialkylamino, cycloalkoxy, cycloalkylsulfanyl, arylsulfanyl and arylsulfinyl,
• provided that:
• (1) at least one of R3, R4, R5, R6, and R7 is other than H.

A method of preparing a compound of the formula A2:

• the method comprising:
• (a) combining a compound of formula C1 with a compound of formula A1 to form a compound of formula C2;
• and
• (b) deprotecting the compound of formula C2 to form the compound of formula A2;
• wherein:
• the compound of formula C1 is:
• the compound of formula A1 is:
• the compound of formula C2 is:
• and
• and wherein, in the compounds of formulae A1, A2 and C2:
• R is:
• and
• R3, R4, R5, R6, and R7 are independently selected from the group consisting of H, halo, alkylsulfonyl, N-hydroxylsulfonamidyl, perhaloalkyl, nitro, aryl, cyano, alkoxy, perhaloalkoxy, alkyl, substituted aryloxy, alkylsulfanyl, alkylsulfinyl, heterocycloalkyl, substituted heterocycloalkyl, dialkylamino, cycloalkoxy, cycloalkylsulfanyl, arylsulfanyl and arylsulfinyl,
• provided that:
• (1) at least one of R3, R4, R5, R6, and R′ is other than H.