# US 11,305,241 B2 · Biological fluid separation device

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- Number: US 11,305,241 B2
- Document ID: US11305241B2
- Status: Granted
- Kind: B2
- Application number: 16/658,350
- Filed: 2019-10-21
- Published: 2020-02-13
- Granted: 2022-04-19
- Earliest claimed: 2016-03-02
- Assignees: Becton, Dickinson and Company
- Applicants: Becton Dickinson and Company
- Inventors: Qihua Xu; Kristin Weidemaier; Christopher Basciano; Sivaramakrishnan Balasubramanian; Patrick Downie
- Web page: https://patentgrep.com/patent/US11305241B2

## CPC

- B01D 71/50: Polycarbonates
- B01D 63/02: Hollow fibre modules
- B01D 63/08: Flat membrane modules
- G01N 33/491: {by separating the blood components (G01N15/05 takes precedence)}
- A61M 1/16: with membranes
- A61M 1/34: Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M 2205/3331: Pressure; Flow
- B01D 29/0004
- B01D 69/06: Flat membranes
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.

## Claims

### Claim 1

A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion, the biological fluid separation device comprising:
a housing, comprising:
a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet wherein the first chamber outlet is placed a lateral distance from the first chamber inlet in the first chamber,
a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating a portion of the first chamber and the second chamber such that the first chamber includes a filtration area underneath the separation member and a non-filtration area that is not underneath the separation member, wherein the first chamber inlet and the first chamber outlet are each placed in a different portion of the non-filtration area,
wherein the separation member defines a tangential flow path along the lateral distance from the first chamber inlet to the first chamber outlet and is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber; and
an actuator in communication with a portion of the housing, wherein the actuator is a vacuum source that provides a first pressure at the first chamber outlet and a second pressure at the second chamber outlet, wherein the first pressure is different from the second pressure and wherein, in response to the actuator, the biological fluid sample is drawn into the first chamber.

### Claim 2 (depends on 1)

The biological fluid separation device of claim 1, wherein the biological fluid sample is whole blood, the first portion is a red blood cell portion and the second portion is a plasma portion.

### Claim 3 (depends on 1)

The biological fluid separation device of claim 1, wherein actuation of the actuator draws the second portion of the biological fluid sample through the separation member.

### Claim 4 (depends on 1)

The biological fluid separation device of claim 1, wherein the vacuum source is an evacuated tube.

### Claim 5 (depends on 1)

The biological fluid separation device of claim 1, wherein the second chamber is a plasma collection container.

### Claim 6 (depends on 1)

The biological fluid separation device of claim 1, further comprising a plasma collection container in communication with the second chamber.

### Claim 7 (depends on 1)

The biological fluid separation device of claim 1, wherein the actuator is a single actuator in communication with the first chamber and the second chamber and which imparts a pressure to a portion of the first chamber to draw the biological fluid sample into the first chamber, and imparts another pressure to a portion of the second chamber to draw a portion of the second portion of the biological fluid sample into the second chamber.

### Claim 8 (depends on 1)

The biological fluid separation device of claim 1, wherein the separation member comprises a track-etched membrane.

### Claim 9 (depends on 8)

The biological fluid separation device of claim 8, wherein the track-etched membrane is a polycarbonate membrane.

### Claim 10 (depends on 1)

The biological fluid separation device of claim 1, further comprising a vent in communication with a portion of the second chamber, the vent transitionable between a closed position in which the vent seals the second chamber, and an open position in which the second chamber is vented to atmosphere.

### Claim 11 (depends on 10)

The biological fluid separation device of claim 10, wherein the vent is provided in the closed position during separation of the second portion of the biological fluid sample from the first portion of the biological fluid sample, and in the open position during removal of the second portion of the biological fluid sample from the second chamber.