# US 11,305,064 B2 · Mixing vial > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,305,064 B2 - Document ID: US11305064B2 - Status: Granted - Kind: B2 - Application number: 15/860,141 - Filed: 2018-01-02 - Published: 2018-07-19 - Granted: 2022-04-19 - Earliest claimed: 2017-01-01 - Assignees: Balanced Pharma Incorporated - Applicants: Balanced Pharma Incorporated - Inventors: John Scott Keadle - Web page: https://patentgrep.com/patent/US11305064B2 ## CPC - A61M 5/2448: {comprising means for injection of two or more media, e.g. by mixing} - A61J 1/2041: {having removable plugs} - A61J 1/2093: {Containers having several compartments for products to be mixed} - A61M 5/19: having more than one chamber - A61M 5/284: {comprising means for injection of two or more media, e.g. by mixing} - A61M 5/315: Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod {or piston}; Appliances on the rod for facilitating dosing {; Dosing mechanisms} - A61M 5/31596: {comprising means for injection of two or more media, e.g. by mixing} - A61M 2005/2451: {preventing delivery before mixing is completed, e.g. by locking mechanisms} - A61M 2005/2462: {by displacing occluding plugs} - A61M 2005/287: {by displacing occluding plugs} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE ## Abstract A mixing vial having a hollow interior chamber with a tubular portion having distal and proximal open ends and a stopper positioned in sealing relationship in the tubular portion, the stopper having a hollow interior chamber with an open end and a dislodgeable plug positioned in and sealing the open end. ## Claims ### Claim 1 A syringe system, the system comprising: a syringe with an axially movable plunger having a distal end defining a shoulder, wherein a harpoon extends axially from the distal end of the plunger, wherein the shoulder has a larger diameter than a harpoon minimum diameter, wherein the harpoon is static with respect to the plunger; and a mixing vial for use in the syringe, said mixing vial including: a vessel, the vessel comprising a hollow interior chamber with proximal and distal ends, a neck at the proximal end, the neck having distal and proximal open ends; and a stopper-pistol the stopper-piston comprising a hollow interior chamber with an open distal end and a closed proximal end, and the entire shipper-piston being slidably positioned in a sealing relationship with said neck, wherein the entire stopper-piston is slidable from a first position to a second position, wherein the entire stopper-piston is adjacent the proximal end of the vessel when in the first position, and wherein the entire stopper-piston is closer to the distal end of the vessel than to the proximal end of the vessel when in the second position; and a dislodgeable plug positioned in and sealing said open distal end of said hollow interior chamber of the stopper-piston, wherein the entire dislodgeable plug is fully dislodgeable as a single piece from the open distal end of the stopper-piston; wherein said stopper-piston comprises a radially inwardly extending flange, wherein the radially inwardly extending flange defines an inward facing annular groove that receives an edge of the dislodgeable plug, wherein a stopper-piston breakout force is required to cause the stopper-piston to slide in a direction from the first position toward the second position, and a plug dislodging force is required to fully dislodge the dislodgeable plug from the inward facing annular groove defined by the radially inwardly extending flange of the stopper-piston in the direction from the first position toward the second position, wherein the plug dislodging force is less than the stopper-piston breakout force; and wherein, when the mixing vial is disposed in the syringe and the plunger is axially moved, the harpoon penetrates the closed proximal end of the stopper-piston, contacts the dislodgeable plug, and fully dislodges the dislodgeable plug prior to the shoulder of the plunger contacting the closed proximal end of the stopper-piston. ### Claim 2 (depends on 1) The system of claim 1, wherein said interior chamber of said vessel comprises an anesthetic, and said interior chamber of said stopper-piston comprises a buffering reagent. ### Claim 3 (depends on 1) The system of claim 1, wherein the syringe comprises a dental syringe, the vessel comprising a shape that allows use with the dental syringe. ### Claim 4 (depends on 1) The system of claim 1, wherein the distal end of the vessel is open and sealed by a sealing cap. ### Claim 5 (depends on 1) The system of claim 1, wherein the stopper-piston comprises an elastomeric plastic or rubber. ### Claim 6 (depends on 4) The system of claim 4, wherein the stopper-piston slides within the hollow interior chamber of the vessel. ### Claim 7 (depends on 4) The system of claim 4, wherein the harpoon pierces the stopper-piston and dislodges the dislodgeable plug when the mixing vial is loaded into or placed in the syringe. ### Claim 8 (depends on 7) The system of claim 7, wherein said interior chamber of said vessel comprises an anesthetic, and said interior chamber of said stopper-piston comprises a buffering reagent, and the anesthetic and the buffering reagent are mixed. ### Claim 9 (depends on 1) The system of claim 1, wherein the plug dislodging force is less than the a force necessary to penetrate the dislodgeable plug. ### Claim 10 (depends on 1) The system of claim 1, wherein the dislodgeable plug includes a strike plate, wherein the dislodgeable plug is disposed within the open distal end of the stopper-piston such that the strike plate faces the hollow interior chamber of the stopper-piston, the strike plate being configured to resist penetration by the harpoon when the harpoon is used to dislodge the dislodgeable plug.