# US 11,305,063 B2 · Medicament delivery device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,305,063 B2 - Document ID: US11305063B2 - Status: Granted - Kind: B2 - Application number: 16/482,363 - Filed: 2018-01-22 - Published: 2020-01-02 - Granted: 2022-04-19 - Earliest claimed: 2017-02-06 - Assignees: Consort Medical PLC - Applicants: Consort Medical PLC - Inventors: Ian Anderson; Alastair Willoughby; Rachel Koppelman - Web page: https://patentgrep.com/patent/US11305063B2 ## CPC - A61M 5/2046: {Media being expelled from injector by gas generation, e.g. explosive charge} - A61M 5/2053: {Media being expelled from injector by pressurised fluid or vacuum (for infusion A61M5/145, A61M5/155)} - A61M 5/3158: {the component being manually operated or triggered by an axially moving actuator operated by user, e.g. an axially movable injection button} - A61M 5/31591: {Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means} - A61M 5/3232: {Semi-automatic needle retraction, i.e. in which triggering of the needle retraction requires a deliberate action by the user, e.g. manual release of spring-biased retraction means} - A61M 5/3234: {Fully automatic needle retraction, i.e. in which triggering of the needle does not require a deliberate action by the user} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A medicament delivery device comprises a housing and a syringe axially movable in the housing and the syringe having a barrel. The device further comprises a stopper axially movable in the barrel and which separates a first chamber and second chamber from one another. The stopper is axially movable in the barrel in response to a vapour pressure being received in the second chamber. The device also includes a biasing mechanism to axially move the syringe in the housing between a first syringe position and a second syringe position in response to a first reduction in the vapour pressure in the second chamber. In the first syringe position venting of the propellant from the second chamber through a first fluid pathway is permitted to enable the first reduction in the vapour pressure in the second chamber while venting of the propellant from the second chamber through a second fluid pathway is substantially prevented. In the second syringe position venting of the propellant from the second chamber through the second fluid pathway is permitted to enable a second reduction in the vapour pressure in the second chamber. ## Claims ### Claim 1 A medicament delivery device comprising: a housing; a syringe axially movable in the housing, the syringe having a barrel; a stopper axially movable in the barrel, the stopper separating a first chamber and a second chamber from one another, the first chamber being axially forward of the stopper and configured to receive a medicament and the second chamber being axially rearward of the stopper and configured to receive a propellant from a propellant source to provide a vapour pressure to the second chamber, the stopper being axially movable in the barrel between a first stopper position and a second stopper position in response to the vapour pressure being received in the second chamber; and a biasing mechanism configured to axially move the syringe in the housing between a first syringe position and a second syringe position in response to a first reduction in the vapour pressure in the second chamber, wherein when the syringe is in the first syringe position, venting of the propellant from the second chamber through a first fluid pathway is permitted to enable the first reduction in the vapour pressure in the second chamber while venting of the propellant from the second chamber through a second fluid pathway is substantially prevented, and wherein when the syringe is in the second syringe position venting of the propellant from the second chamber through the second fluid pathway is permitted to enable a second reduction in the vapour pressure in the second chamber. ### Claim 2 (depends on 1) The medicament delivery device of claim 1, wherein the first and second fluid pathways are configured to enable a faster flow rate of propellant out of the second chamber when venting the propellant from the second chamber through the second fluid pathway than when venting the propellant from the second chamber through the first fluid pathway. ### Claim 3 (depends on 1) The medicament delivery device of claim 1, wherein when the stopper is in the first stopper position venting of the propellant from the second chamber through the first fluid pathway is substantially prevented and when the stopper is in the second stopper position, venting of the propellant from the second chamber through the first fluid pathway is permitted to enable the first reduction in the vapour pressure in the second chamber. ### Claim 4 (depends on 1) The medicament delivery device of claim 1, wherein the biasing mechanism is configured to axially move the syringe between the second syringe position and a third syringe position in response to the second reduction in the vapour pressure in the second chamber. ### Claim 5 (depends on 1) The medicament delivery device of claim 1, wherein the medicament delivery device further comprises an expandable drive mechanism configured to receive the propellant from the propellant source to provide a vapour pressure to the expandable drive mechanism, the expandable drive mechanism being expandable in response to receiving the vapour pressure in the expandable drive mechanism to cause forward axial movement of the syringe in the housing. ### Claim 6 (depends on 5) The medicament delivery device of claim 5, wherein the biasing mechanism is configured to axially move the syringe between the second syringe position and a third syringe position in response to the second reduction in the vapour pressure in the second chamber and wherein the syringe is axially moveable between the third syringe position and the first syringe position in response to the vapour pressure being received in the expandable drive mechanism. ### Claim 7 (depends on 5) The medicament delivery device of claim 5, wherein the expandable drive mechanism comprises a first part fluidly sealable to the propellant source and a second part fluidly sealable to the barrel of the syringe, the second part being slidably and sealably engaged with the first part so as to be capable of expanding the expandable drive mechanism in response to the vapour pressure being received in the expandable drive mechanism. ### Claim 8 (depends on 5) The medicament delivery device of claim 5, wherein the expandable drive mechanism at least partially defines a third chamber configured to receive the propellant from the propellant source and the second chamber is configured to receive the propellant from the propellant source through the third chamber. ### Claim 9 (depends on 5) The medicament delivery device of claim 5, wherein the biasing mechanism is configured to axially move the syringe between the second syringe position and a third syringe position in response to the second reduction in the vapour pressure in the second chamber; and where the biasing mechanism is compressible in response to the syringe being moved axially forward relative to the housing so as to provide at least in part a biasing force for biasing the syringe between the second syringe position and the third syringe position. ### Claim 10 (depends on 1) The medicament delivery device of claim 1, wherein the biasing mechanism is compressible in response to the syringe being moved axially forward relative to the housing so as to provide at least in part a biasing force for biasing the syringe between the first syringe position and the second syringe position. ### Claim 11 (depends on 1) The medicament delivery device of claim 1, wherein the biasing mechanism comprises a spring. ### Claim 12 (depends on 1) The medicament delivery device of claim 1, wherein the stopper is configured to selectively separate an opening of the first fluid pathway and the second chamber from one another to selectively prevent venting of the propellant from the second chamber through the first fluid pathway. ### Claim 13 (depends on 1) The medicament delivery device of claim 1, wherein the medicament delivery device further comprises a sealing surface configured to selectively seal an opening of the second fluid pathway to selectively prevent venting of the propellant from the second chamber through the second fluid pathway. ### Claim 14 (depends on 13) The medicament delivery device of claim 13, wherein the sealing surface seals the opening of the second fluid pathway in response to the vapour pressure in an expandable drive mechanism, the expandable drive mechanism being configured to receive the propellant from the propellant source to provide a vapour pressure to the expandable drive mechanism, the expandable drive mechanism being expandable in response to receiving the vapour pressure in the expandable drive mechanism to cause forward axial movement of the syringe in the housing. ### Claim 15 (depends on 13) The medicament delivery device of claim 13, wherein the sealing surface seals the opening of the second fluid pathway in response to axially forward movement of the syringe. ### Claim 16 (depends on 13) The medicament delivery device of claim 13, wherein the sealing surface comprises a resilient material. ### Claim 17 (depends on 13) The medicament delivery device of claim 13, wherein the housing comprises the sealing surface. ### Claim 18 (depends on 1) The medicament delivery device of claim 1, wherein the medicament delivery device further comprises the propellant source. ### Claim 19 (depends on 1) The medicament delivery device of claim 1, wherein the propellant source comprises a volume of a liquefied gas propellant. ### Claim 20 (depends on 1) The medicament delivery device of claim 1, wherein the propellant source comprises a propellant which includes at least one of the group consisting of a hydrofluoroalkane (“HFA”) and a hydrofluoroolefin (“HFO”).