# US 11,304,987 B2 · Argan extracts for the treatment of dermatological conditions

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- Number: US 11,304,987 B2
- Document ID: US11304987B2
- Status: Granted
- Kind: B2
- Application number: 16/809,148
- Filed: 2020-03-04
- Published: 2020-09-10
- Granted: 2022-04-19
- Earliest claimed: 2019-03-05
- Assignees: Fre Skincare Ltd
- Applicants: Fre Skincare Ltd
- Inventors: Michael Azoulay; Mickael Bensadoun; Sharon Rozenblat
- Web page: https://patentgrep.com/patent/US11304987B2

## CPC

- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 8/922: {of vegetable origin}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 31/661: Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion {or mevinphos}
- A61K 35/02: from inanimate materials (carbon A61K33/44)
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61P 17/06: Antipsoriatics
- A61P 17/08: Antiseborrheics
- A61P 17/10: Anti-acne agents
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/004: {Aftersun preparations}
- A61Q 19/08: Anti-ageing preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The application provides compositions, in particular dermatological compositions comprising extracts from argan tree for the treatment and prevention of dermatological conditions. More particularly, a composition comprising argan oil (AO), argan leaf extract (AL) and argan stem cells (ASC) is provided. Further provided is a method for reducing photoaging of the skin of a subject due to exposure to UV radiation which comprises applying the composition of the invention to the subject prior to exposure to UV radiation.

## Claims

### Claim 1

An emulsion having synergistic interleukin 6 inhibition comprising argan kernel oil, wherein the argan kernel oil is a cold pressed extract from kernel, argania spinosa leaf extract wherein the argania spinosa was extracted with water and/or glycerin; and Argania spinosa sprout cell culture extract that contains 50% of argania spinosa stem cell culture with isomalt, lecithin, sodium benzoate and water.

### Claim 2 (depends on 1)

The emulsion of claim 1, wherein the argan kernel oil, argan leaf extract and argan stem cells form a complex.

### Claim 3 (depends on 1)

The emulsion of claim 1, for treating a dermatological condition in a human.

### Claim 4 (depends on 3)

The emulsion of claim 3, wherein the dermatological condition is selected from the group consisting of ultraviolet radiation-induced skin damage, acne, atopic dermatitis, eczema, psoriasis, seborrhea, rocacea and combinations thereof.

### Claim 5 (depends on 1)

The emulsion of claim 1, wherein the combination of at least two of argan kernel oil, argan leaf extract, and argan stem cells has an antioxidative synergistic activity.

### Claim 6 (depends on 5)

The emulsion of claim 5, wherein the combination of argan kernel oil and argan stem cells has an antioxidative synergistic activity.

### Claim 7 (depends on 1)

The emulsion of claim 1, wherein the combination of at least two of argan kernel oil, argan leaf extract, and argan stem cells has an anti-inflammatory synergistic activity.

### Claim 8 (depends on 7)

The emulsion of claim 7, for daily use by the human.

### Claim 9 (depends on 1)

The emulsion of claim 1, wherein the ratio between argan kernel oil to argan leaf extract is about 1:1 and the ratio between argan kernel oil and argan stem cells is 1:0.001 to 1:0.2.

### Claim 10 (depends on 1)

The emulsion of claim 1, wherein the ratio between argan kernel oil to argan leaf extract is about 1:1.

### Claim 11 (depends on 1)

The emulsion of claim 1, wherein the argan stem cell levels are between about 0.001%-1%.

### Claim 12 (depends on 1)

A method of treating one or more of ultraviolet radiation-induced skin damage, acne, atopic dermatitis, eczema, psoriasis, seborrhea and rosacea, in a human in need thereof comprising contacting the human's skin with the emulsion of claim 1.

### Claim 13 (depends on 12)

The method of claim 12, wherein the contacting of the human's skin with the emulsion is performed before, during and/or after the exposure to ultraviolet raditation.

### Claim 14 (depends on 12)

The method of claim 12, wherein the human is an athlete.