# US 11,304,981 B2 · Platelet lysate gel

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- Number: US 11,304,981 B2
- Document ID: US11304981B2
- Status: Granted
- Kind: B2
- Application number: 16/165,627
- Filed: 2018-10-19
- Published: 2019-05-30
- Granted: 2022-04-19
- Earliest claimed: 2011-11-23
- Assignees: Cell Therapy Limited
- Applicants: Cell Therapy Limited
- Inventors: Thomas Averell Houze; Martin John Evans; Ajan Trevor Reginald; Ina Laura Pieper
- Web page: https://patentgrep.com/patent/US11304981B2

## CPC

- A61K 35/19: Platelets; Megacaryocytes
- A61K 8/042: {Gels}
- A61K 8/19: containing inorganic ingredients
- A61K 8/27: Zinc; Compounds thereof
- A61K 8/43: Guanidines
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/447: {containing sulfur}
- A61K 8/4913: {having five membered rings, e.g. pyrrolidone carboxylic acid}
- A61K 8/4946: {Imidazoles or their condensed derivatives, e.g. benzimidazoles}
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/72: containing organic macromolecular compounds
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/96: containing materials, or derivatives thereof of undetermined constitution
- A61K 8/983: {Blood, e.g. plasma}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0031: {Rectum, anus}
- A61K 9/0034: {Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants}
- A61K 35/12: Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells (vaccines or medicinal preparations containing antigens or antibodies A61K39/00)
- A61K 35/16: Blood plasma; Blood serum (umbilical cord blood A61K35/51)
- A61K 35/33: Fibroblasts
- A61L 26/0019: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds}
- A61L 26/0023: {Polysaccharides}
- A61L 26/0061: {Use of materials characterised by their function or physical properties}
- A61L 26/008: {Hydrogels or hydrocolloids}
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 15/02: for disorders of the vagina
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61Q 19/08: Anti-ageing preparations
- C12N 5/0644: {Platelets; Megakaryocytes}
- A61K 2800/524: Preservatives
- A61L 2300/30: Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

The invention concerns a pharmaceutical composition comprising a platelet lysate and its use to treat a wound, an anal fissure, vaginal atrophy or a wrinkle.

## Claims

### Claim 1

A pharmaceutical composition in the form of a gel comprising a human platelet lysate produced according to a method comprising (a) subjecting a population of human platelets to four freeze-thaw cycles, wherein the freeze portion of each cycle is carried out at a temperature lower than or equal to −190° C. and (b) mixing the platelet lysate with at least one pharmaceutically acceptable polymer and at least one pharmaceutically acceptable positively charged chemical species such that the resulting composition is an aqueous gel having a viscosity in the range of 1000 to 500,000 mPa·s (cps) at room temperature.