# US 11,304,967 B2 · Compounds and compositions for improving power output and oxygen efficiency

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- Number: US 11,304,967 B2
- Document ID: US11304967B2
- Status: Granted
- Kind: B2
- Application number: 15/548,369
- Filed: 2016-02-11
- Published: 2018-02-01
- Granted: 2022-04-19
- Earliest claimed: 2015-02-11
- Assignees: BioActor BV
- Applicants: Bioactor BV
- Inventors: Antonie Johannes Van Der Saag; Sam Possemiers
- Web page: https://patentgrep.com/patent/US11304967B2

## CPC

- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 31/353: 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides the use of a compound of formula I, and compositions comprising such a compound, for improving power output and/or oxygen efficiency in a subject.

## Claims

### Claim 1

A method for improving oxygen efficiency by lowering the ratio of oxygen consumption over power output, the ratio represented by VO2/power, in a healthy subject, the method comprising administering prior to physical exercise and/or the onset of stress caused by such exercise to the subject a composition comprising hesperidin in a mixture of R- and S-enantiomers, wherein the R:S molar ratio of the mixture is between 1:2 and 1:5,
and wherein the healthy subject is selected from a trained athlete, a moderately trained subject or an untrained subject.

### Claim 2 (depends on 1)

The method of claim 1 wherein the method results in increased power output during physical activity.

### Claim 3 (depends on 1)

The method of claim 1, wherein said composition is administered orally.

### Claim 4 (depends on 1)

The method of claim 1, wherein the method results in increased power output while maintaining or lowering oxygen consumption.

### Claim 5 (depends on 1)

The method as claimed in claim 1, wherein the mixture is administered once daily in an amount of 250-1000 mg.

### Claim 6 (depends on 5)

The method as claimed in claim 5, wherein the mixture is administered once daily in an amount of 400-600 mg.

### Claim 7 (depends on 6)

The method as claimed in claim 6, wherein the mixture is administered once daily in an amount of 450-550 mg.