# US 11,304,956 B2 · Use of 7-bromo-5-(O-chlorophenyl)-3-propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one for inhibition of neuropathic pain and seizures of different etiology

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- Number: US 11,304,956 B2
- Document ID: US11304956B2
- Status: Granted
- Kind: B2
- Application number: 16/338,902
- Filed: 2017-10-26
- Published: 2021-06-10
- Granted: 2022-04-19
- Earliest claimed: 2016-10-03
- Assignees: Anatoly Semenovich Reder; Dmytro Volodymyrovich Pozigun
- Applicants: Anatoliy Semenovich Reder; Dmytro Volodymyrovich Pozigun
- Inventors: Anatoly Semenovich Reder; Sergey Andreevich Adronati; Mykola Yakovich Golovenko; Viktor Ivanovich Pavlovskiy; Tatiyana Anatolyevna Kabanova; Olena Igorivna Khalimova; Vitaly Borysovich Larionov; Natalia Ivanivna Voloshchuk
- Web page: https://patentgrep.com/patent/US11304956B2

## CPC

- A61K 31/5513: 1,4-Benzodiazepines, e.g. diazepam {or clozapine}
- A61K 9/00: Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations A61K49/18; preparations containing radioactive substances A61K51/12)}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61P 23/00: Anaesthetics
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 25/08: Antiepileptics; Anticonvulsants
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C07D 243/24: Oxygen atoms
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The invention relates to medical chemistry, in particular to the use of 7-bromo-5-(o-chlorophenyl)-3-propoxy-1,2-di-hydro-3H-1,4-benzodiazepin-2-one as a drug which inhibits neuropathic pain without the formation of defects in the gastric mucosa (ulcerogenic effect), and possesses an anticonvulsant property.

## Claims

### Claim 1

A method for treating neuropathic pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound of formula (I):

### Claim 2 (depends on 1)

The method of claim 1, further comprising mitigating a side effect of an ulcerogenic event in the subject.

### Claim 3 (depends on 1)

The method of claim 1, wherein the neuropathic pain is caused by diabetes mellitus, herpetic infection, stroke, multiple sclerosis, malignant diseases, HIV infection, or post-traumatic or postoperative damage to the peripheral nervous system.

### Claim 4 (depends on 1)

The method of claim 1, wherein the therapeutically effective amount of the compound of formula (I) is administered orally or intraperitoneally.