# US 11,304,955 B2 · Small-molecule povidone analogs in coamorphous pharmaceutical phases

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- Number: US 11,304,955 B2
- Document ID: US11304955B2
- Status: Granted
- Kind: B2
- Application number: 16/620,831
- Filed: 2018-06-11
- Published: 2020-06-18
- Granted: 2022-04-19
- Earliest claimed: 2017-06-09
- Assignees: ISP Investments Inc.
- Applicants: Isp Investments LLC
- Inventors: Osama M. Musa; Jonathan W. Steed; David Berry; Melissa J. Goodwin
- Web page: https://patentgrep.com/patent/US11304955B2

## CPC

- A61K 31/522: having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A61K 31/55: having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K 9/145: {with organic compounds}
- A61K 31/135: having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)}
- A61K 31/136: having the amino group directly attached to the aromatic ring, e.g. benzeneamine
- A61K 31/137: Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone}
- A61K 31/14: Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205)
- A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 31/27: of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A61K 31/381: having five-membered rings
- A61K 31/41: having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K 31/44: Non condensed pyridines; Hydrogenated derivatives thereof
- A61K 31/4409: only substituted in position 4, e.g. isoniazid, iproniazid
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

An amorphous dispersion comprises bis(vinylcaprolactam) and an active pharmaceutical ingredient.

## Claims

### Claim 1

An amorphous dispersion comprising
(a) a compound having a structure of
and
(b) an active pharmaceutical ingredient selected from the group consisting of
wherein the mole ratio of said active pharmaceutical ingredient (b) to said compound (a) ranges from 1:1 to 3:1.