# US 11,304,934 B2 · Use of isoxazoline derivatives for the treatment or prevention of arthropod infestations in poultry

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- Number: US 11,304,934 B2
- Document ID: US11304934B2
- Status: Granted
- Kind: B2
- Application number: 16/849,487
- Filed: 2020-04-15
- Published: 2020-07-30
- Granted: 2022-04-19
- Earliest claimed: 2013-12-20
- Assignees: Intervet Inc.
- Applicants: Intervet Inc.
- Inventors: Anja Regina Heckeroth; Hartmut Zoller; Annie Flochlay-Sigognault; Bruno Huyghe
- Web page: https://patentgrep.com/patent/US11304934B2

## CPC

- A61K 31/42: Oxazoles
- A01N 43/80: five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
- A01N 43/90: having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 31/422: not condensed and containing further heterocyclic rings
- A61K 31/437: the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61P 33/14: Ectoparasiticides, e.g. scabicides
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to methods of treating or preventing arthropod infestations of poultry animals and methods of controlling arthropod infestations in poultry animal's environment by administering an isoxazoline compound of formula (I) via drinking water.

## Claims

### Claim 1

A method of preventing or treating an infestations of a laying hen by a temporary parasitic arthropod comprising administering via the drinking water an effective amount of an isoxazoline compound wherein the isoxazoline compound is sarolaner or a salt or solvate thereof

### Claim 2 (depends on 1)

The method according to claim 1 wherein the temporary parasitic arthropod is selected from fowl ticks (Argas persicus), poultry red mites (Dermanyssus gallinae), tropical fowl mite (Ornithonyssus bursa) and bed bugs (Cimex lectularius).

### Claim 3 (depends on 1)

The method according to claim 1 wherein the temporary parasitic arthropod infestation is a mite infestation.

### Claim 4 (depends on 1)

The method of claim 1 wherein the temporary parasitic arthropod infestation is an infestation by Dermanyssus spp. and/or Ornithonyssus spp. mites.

### Claim 5 (depends on 1)

The method of claim 1 wherein the temporary parasitic arthropod infestation is an infestation by Dermanyssus gallinae.

### Claim 6 (depends on 1)

The method according to claim 1 wherein the effective amount is between 0.01 and 50 mg/kg body weight of animals treated.

### Claim 7 (depends on 1)

The method according to claim 1 wherein the effective dose of the isoxazoline compound is administered via the drinking water in two separate dosages.

### Claim 8 (depends on 7)

The method according to claim 7 wherein the two separate dosages of isoxazoline compound are administered approximately 7 days apart.

### Claim 9 (depends on 7)

The method according to claim 7 wherein the two separate dosages of isoxazoline compound are administered approximately 14 days apart.

### Claim 10

A method for the prevention or treatment of parasitic arthropod infestations of laying hens during the laying period comprising administering via drinking water an effective amount of an isoxazoline compound wherein the isoxazoline compound is sarolaner or a salt or solvate thereof, and a pharmaceutically acceptable carrier.

### Claim 11

A Method of controlling darkling beetles in the environment of poultry animals comprising administering via drinking water an effective amount of an isoxazoline compound wherein the isoxazoline compound is sarolaner or a salt or solvate thereof.