# US 11,304,931 B1 · Method of treating subject exposed to radiation in space > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,304,931 B1 - Document ID: US11304931B1 - Status: Granted - Kind: B1 - Application number: 16/164,019 - Filed: 2018-10-18 - Granted: 2022-04-19 - Earliest claimed: 2017-11-13 - Applicants: Adam M. Hasse - Inventors: Adam M. Hasse - Web page: https://patentgrep.com/patent/US11304931B1 ## CPC - A61K 31/409: having four such rings, e.g. porphine derivatives, bilirubin, biliverdine (hemin, hematin A61K31/555) - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B 5/14556: {by fluorescence (A61B5/14555 takes precedence)} - A61N 5/06: using light - A61N 5/0613: {Apparatus adapted for a specific treatment} - A61N 5/062: {Photodynamic therapy, i.e. excitation of an agent} - A61N 2005/0636: {Irradiating the whole body} - A61N 2005/0645: {Applicators worn by the patient} - A61N 2005/0651: {Diodes} - A61N 2005/0653: {Organic light emitting diodes} - A61N 2005/0654: {Lamps} - A61N 2005/0661: {ultraviolet} - A61N 2005/0662: {Visible light} - A61N 2005/0667: {Filters} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Methods of treating a human subject exposed to radiation in space. The methods include the steps of administering to the subject in space a chlorophyll composition sufficient to provide at least about 0.15 μM of chlorophyll or its metabolites to the subject's bloodstream, and then exposing the subject in space to light having a wavelength of about 620 nm to about 760 nm and an intensity of about 5 W/m2 to about 1000 W/m2 for at least about 5 minutes. Methods for estimating the level of ubiquinol in the bloodstream of a subject having chlorophyll or chlorophyll metabolite in the bloodstream, which may be after treatment by the above methods, include the steps of exposing the subject's skin to light to induce fluorescence of the chlorophyll or chlorophyll metabolite, measuring the level of fluorescing chlorophyll or chlorophyll metabolite in the bloodstream using fluorescence spectroscopy, and correlating the level of fluorescing chlorophyll or chlorophyll metabolite to the level of ubiquinol using a predetermined scaling factor. ## Claims ### Claim 1 A method of treating a human subject exposed to radiation in space, the method comprising the steps of: (1) administering to the subject in space a chlorophyll composition sufficient to provide at least 1.0 μM of chlorophyll or its metabolites to the subject's bloodstream, and (2) then exposing the subject in space to light having a wavelength of 620 nm to 760 nm and an intensity of 5 W/m2 to 1000 W/m2 for at least 5 minutes to activate the chlorophyll composition in the bloodstream and catalyze the regeneration of ubiquinol antioxidant in the subject to reduce the risk of and ameliorate harmful effects from exposure to radiation in space. ### Claim 2 (depends on 1) The method of claim 1 where the steps (1) and (2) occur on at least a daily basis during the period of exposure to radiation in space. ### Claim 3 (depends on 1) The method of claim 1 where the steps (1) and (2) occur at least twice a day during the period of exposure to radiation in space. ### Claim 4 (depends on 1) The method of claim 1 where the chlorophyll composition provides at least 2.5 μM of chlorophyll or its metabolites to the subject's bloodstream. ### Claim 5 (depends on 1) The method of claim 1 where the step (2) occurs within a period of 1 hour to 10 hours after the step (1). ### Claim 6 (depends on 1) The method of claim 1 where in step (2) the subject is exposed to light having a wavelength of 620 nm to 700 nm and an intensity of 5 W/m2 to 500 W/m2 for at least 10 minutes. ### Claim 7 (depends on 1) The method of claim 1 where in step (2) the subject is exposed to light having a wavelength of 630 nm to 670 nm and an intensity of 5 W/m2 to 300 W/m2 for at least 20 minutes. ### Claim 8 (depends on 1) The method of claim 1 where in step (2) the light is provided by an LED light source. ### Claim 9 (depends on 1) The method of claim 1 further comprising exposing the subject to ultraviolet light having a wavelength of 270 nm to 320 nm for at least 10 minutes. ### Claim 10 (depends on 1) The method of claim 1 where Vitamin C is present in the subject's bloodstream. ### Claim 11 (depends on 1) The method of claim 1 further comprising administering to the subject on at least a daily basis a radiation-oxidative exposure treatment composition comprising micronutrient multivitamins, trace elements, antioxidants, chemopreventative agents, and fatty acids, and mixtures thereof. ### Claim 12 A method of treating a human subject exposed to radiation in space, the method comprising the steps of: (1) administering to the subject in space a chlorophyll composition sufficient to provide at least 1.0 μM of chlorophyll or its metabolites to the subject's bloodstream, and (2) then exposing the subject in space to light having a wavelength of 620 nm to 760 nm and an intensity of 5 W/m2 to 300 W/m2 for at least 20 minutes to activate the chlorophyll composition in the bloodstream and catalyze the regeneration of ubiquinol antioxidant in the subject to reduce the risk of and ameliorate harmful effects from exposure to radiation in space, where the steps (1) and (2) occur on at least a daily basis during the period of exposure to radiation in space.