# US 11,304,922 B1 · Pharmaceutical micronutrient composition for simultaneously treating nervous system function, cognitive ability and response to stressors

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- Number: US 11,304,922 B1
- Document ID: US11304922B1
- Status: Granted
- Kind: B1
- Application number: 17/552,189
- Filed: 2021-12-15
- Granted: 2022-04-19
- Earliest claimed: 2021-07-12
- Assignees: Matthias W. Rath
- Applicants: Matthias W Rath
- Inventors: Aleksandra Niedzwiecki; Matthias W Rath; Parthena Boulikas; Anna Goc
- Web page: https://patentgrep.com/patent/US11304922B1

## CPC

- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/175: Amino acids
- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 31/205: Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A61K 31/221: with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
- A61K 31/4745: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48)
- A61K 31/7084: Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
- A61K 36/23: Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K 36/258: Panax (ginseng)
- A61K 36/41: Crassulaceae (Stonecrop family)
- A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K 36/68: Plantaginaceae (Plantain Family)
- A61K 36/738: Rosa (rose)
- A61K 36/80: Scrophulariaceae (Figwort family)
- A61K 36/899: Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61P 25/00: Drugs for disorders of the nervous system
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A pharmaceutical composition of micronutrients were tried to improve cognitive brain function, brain health and nervous system functions. Combination consisting of Avena sativa (green oat straw extract), Coenzyme Q10, NAD+, American Ginseng, and Pyrroloquinoline quinone in physiological dose range shows multiple simultaneous positive effects in supporting key functions in cells building our nervous system essential for optimum mental and/or cognitive health including protecting nervous system cells against various damaging factors, increasing ATP production, stimulating mitochondria biogenesis, increasing mitochondrial membrane potential, increasing mitochondrial functions (Complex I activity), exhibiting anti-inflammatory capacity and increased BDNF secretion.

## Claims

### Claim 1

A pharmaceutical micronutrient composition,
consisting of:
Avena sativa in the range of 1 mg to 50,000 mg, Coenzyme Q10 in the range of 10 mcg to 20,000 mg, NAD+ in the range of 0.1 mg to 20,000 mg, American Ginseng in the range of 1 mg to 50,000 mg, and Pyrroloquinoline quinone in the range of 0.1 mg to 50,000 mg formulated as a tablet, coated tablet, capsule, pill, lozenges, emulsion, pastilles, suppository, or paste.

### Claim 2 (depends on 1)

The pharmaceutical micronutrient composition according to claim 1, wherein the pharmaceutical micronutrient composition is used for a treatment of cognitive impairment, depression and other nervous system problems in the human and other species.

### Claim 3 (depends on 2)

The pharmaceutical micronutrient composition according to claim 2, wherein a cognitive impairment is linked to mitochondrial dysfunction.

### Claim 4 (depends on 2)

The pharmaceutical micronutrient composition according to claim 2, wherein a cognitive impairment is linked to dysfunction in BDNF secretion.

### Claim 5 (depends on 2)

The pharmaceutical micronutrient composition according to claim 2, wherein a cognitive impairment is linked to exposure to excessive stress due to mental and chemical conditions.

### Claim 6 (depends on 1)

The pharmaceutical micronutrient composition according to claim 1, wherein the pharmaceutical micronutrient composition is used for maintaining healthy function of the nervous system in the human and other species.

### Claim 7 (depends on 1)

The pharmaceutical micronutrient composition according to claim 1, wherein the pharmaceutical micronutrient composition is used for preventing and mitigating the decline in cognitive and behavioral abilities due to age and other external and internal factors, wherein the pharmaceutical micronutrient composition is used for maintaining healthy function of the nervous system in the human and other species.

### Claim 8 (depends on 1)

The pharmaceutical micronutrient composition of claim 1, wherein the American Ginseng is from natural source as a whole plant, an extract or a combination thereof and Coenzyme Q10 is from a natural source and synthetic source.

### Claim 9 (depends on 1)

The pharmaceutical micronutrient composition of claim 1, wherein the NAD+ is from a natural source, synthetic source or a combination thereof, Pyrroloquinoline quinone is from a natural source, synthetic source or a combination thereof.