# US 11,304,921 B1 · Pharmaceutical micronutrient composition and its use to simultaneously treat nervous system function, cognitive ability and response to stressors > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,304,921 B1 - Document ID: US11304921B1 - Status: Granted - Kind: B1 - Application number: 17/549,086 - Filed: 2021-12-13 - Granted: 2022-04-19 - Earliest claimed: 2021-07-12 - Assignees: Matthias W. Rath - Applicants: Matthias W Rath - Inventors: Aleksandra Niedzwiecki; Matthias W Rath; Parthena Boulikas; Anna Goc - Web page: https://patentgrep.com/patent/US11304921B1 ## CPC - A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) - A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21) - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A23L 33/175: Amino acids - A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin - A61K 31/205: Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine - A61K 31/221: with compounds having an amino group, e.g. acetylcholine, acetylcarnitine - A61K 31/4745: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48) - A61K 31/7084: Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide - A61K 36/23: Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin - A61K 36/258: Panax (ginseng) - A61K 36/41: Crassulaceae (Stonecrop family) - A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae - A61K 36/68: Plantaginaceae (Plantain Family) - A61K 36/738: Rosa (rose) - A61K 36/80: Scrophulariaceae (Figwort family) - A61K 36/899: Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane - A61P 25/00: Drugs for disorders of the nervous system - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A pharmaceutical composition of micronutrients were tried to improve brain health and nervous system functions. Combination of L-theanine, Rhodiola rosea, Acetyl L-Carnitine (ALCAR), Bacopa monnieri, Mucuna pruriens, NAD+, Rose hips extract (trans-tiliroside), American Ginseng, Pyrroloquinoline quinone, Gotu Kola in physiological dose range shows multiple simultaneous positive effects in supporting key functions in cells building our nervous system essential for optimum mental and/or cognitive health including protecting nervous system cells against various damaging factors, increasing ATP production, stimulating mitochondria biogenesis, increasing mitochondrial membrane potential, increasing mitochondrial functions (Complex I activity), exhibiting anti-inflammatory capacity and increased BDNF secretion. ## Claims ### Claim 1 A pharmaceutical micronutrient composition, comprising; a L-theanine in the range of 0.1 mg to 10,000 mg, Rhodiola rosea in the range of 1 mg to 10,000 mg, Acetyl L-Carnitine in the range of 0.1 mg to 10,000 mg, Bacopa monnieri in the range of 1 mg to 10,000 mg, Mucuna pruriens in the range of 1 mg to 50,000 mg, NAD+ in the range of 0.1 mg to 20,000 mg, Rose hips extract in the range of 5 mg to 10,000 mg, American Ginseng in the range of 1 mg to 50,000 mg, Pyrroloquinoline quinone in the range of 0.1 mg to 50,000 mg, Gotu Kola in the range of 1 mg to 50,000 mg formulated as a tablet, coated tablet, capsule, pill, lozenges, emulsion, pastilles, suppository, or paste. ### Claim 2 (depends on 1) The pharmaceutical micronutrient composition according to claim 1, wherein the pharmaceutical micronutrient composition is used for a treatment of cognitive impairment, depression and other nervous system problems in the human and other species. ### Claim 3 (depends on 2) The pharmaceutical micronutrient composition according to claim 2, wherein a cognitive impairment is linked to mitochondrial dysfunction. ### Claim 4 (depends on 2) The pharmaceutical micronutrient composition according to claim 2, wherein a cognitive impairment is linked to dysfunction in BDNF secretion. ### Claim 5 (depends on 2) The pharmaceutical micronutrient composition according to claim 2, wherein a cognitive impairment is linked to exposure to excessive stress due to mental and chemical conditions. ### Claim 6 (depends on 1) The pharmaceutical micronutrient composition according to claim 1, wherein the pharmaceutical micronutrient composition is used for maintaining healthy function of the nervous system in the human and other species. ### Claim 7 (depends on 1) The pharmaceutical micronutrient composition according to claim 1, wherein the pharmaceutical micronutrient composition is used for preventing and mitigating the decline in cognitive and behavioral abilities due to age and other external and internal factors, wherein the pharmaceutical micronutrient composition is used for maintaining healthy function of the nervous system in the human and other species. ### Claim 8 (depends on 1) The pharmaceutical micronutrient composition of claim 1, wherein the Rhodiola rosea is from natural source as a whole plant, extract or a combination thereof, Bacopa monnieri is from natural source as a whole plant, an extract or a combination thereof, Mucuna pruriens is from natural source as a whole plant, an extract or a combination thereof, Rose hips extract from natural source as a whole plant, an extract or a combination thereof, American Ginseng is from natural source as a whole plant, an extract or a combination thereof, Gotu Kola is from natural source as a whole plant, an extract or a combination thereof. ### Claim 9 (depends on 1) The pharmaceutical micronutrient composition of claim 1, wherein the L-theanine is from natural and synthetic source, ALCAR is from a natural source and synthetic source, NAD+ is from a natural source and synthetic source, Pyrroloquinoline quinone is from a natural source and synthetic source.