# US 11,304,918 B2 · Methods and compositions for the treatment of diverticulosis

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- Number: US 11,304,918 B2
- Document ID: US11304918B2
- Status: Granted
- Kind: B2
- Application number: 16/501,039
- Filed: 2019-02-11
- Published: 2019-07-04
- Granted: 2022-04-19
- Earliest claimed: 2011-12-19
- Assignees: Emmaus Medical, Inc.
- Applicants: Emmaus Medical, Inc.
- Inventors: Yutaka Niihara
- Web page: https://patentgrep.com/patent/US11304918B2

## CPC

- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/175: Amino acids
- A23L 33/24: Cellulose or derivatives thereof
- A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)}
- A61K 31/717: Celluloses
- A61K 31/721: Dextrans
- A61K 36/68: Plantaginaceae (Plantain Family)
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The present invention is directed to methods and compositions for the treatment of diverticulosis. It is more specifically directed to compositions including L-glutamine, its salts, or its derivatives, and uses of such compositions in the treatment of diverticulosis. In a method aspect, the present invention provides a method of treating diverticulosis. The method includes ingestion of 0.05 g/kg body weight to 10.0 g/kg body weight of L-glutamine, an L-glutamine salt or an L-glutamine derivative per day by a person who has diverticulosis.

## Claims

### Claim 1

A method of treating diverticulosis, wherein the method consist essentially of ingestion of 0.05 g/kg body weight to 10 g/kg body weight of L-glutamine by a person who has diverticulosis, wherein L-glutamine is the only active ingredient.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the L-glutamine is ingested as part of an aqueous solution or suspension.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the L-glutamine is ingested for a period of at least six months.

### Claim 4 (depends on 3)

The method according to claim 3, wherein the number of diverticula in the person with diverticulosis is reduced by at least fifty percent.