# US 11,304,896 B2 · Antioxidant infused gum for improving oral health > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,304,896 B2 - Document ID: US11304896B2 - Status: Granted - Kind: B2 - Application number: 16/527,908 - Filed: 2019-07-31 - Published: 2020-02-06 - Granted: 2022-04-19 - Earliest claimed: 2018-07-31 - Assignees: The Board of Trustees of The University of Alabama - Applicants: The Board of Trustees of the University of Alabama - Inventors: Kristi Crowe-White - Web page: https://patentgrep.com/patent/US11304896B2 ## CPC - A23L 27/33: {containing sugars or derivatives} - A61K 9/0058: {Chewing gums (non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00)} - A23L 27/10: Natural spices, flavouring agents or condiments; Extracts thereof - A23L 29/30: containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin (products from apiculture A23L21/20; artificial sweetening agents A23L27/30) - A23L 33/105: Plant extracts, their artificial duplicates or their derivatives - A23L 33/125: containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates (indigestible substances A23L33/21) - A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics - A61K 8/67: Vitamins - A61K 8/9789: Magnoliopsida [dicotyledons] - A61K 36/185: Magnoliopsida (dicotyledons) - A61K 36/534: Mentha (mint) - A61K 36/537: Salvia (sage) - A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras - A61K 36/61: Myrtaceae (Myrtle family), e.g. teatree or eucalyptus - A61K 36/66: Papaveraceae (Poppy family), e.g. bloodroot - A61K 36/752: Citrus, e.g. lime, orange or lemon - A61K 36/82: Theaceae (Tea family), e.g. camellia - A61K 36/8962: Allium, e.g. garden onion, leek, garlic or chives - A61K 36/9066: Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger - A61K 36/9068: Zingiber, e.g. garden ginger - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract Disclosed herein are compositions and methods for treating, reducing or preventing oxidative stress in a subject. The compositions can be chewable confectionaries comprising a chewable base, one or more unprocessed phytochemical ingredients, and a sweetener comprising allulose. The unprocessed phytochemical ingredients can include ground plant materials selected from cinnamon, nutmeg, allspice, or combinations thereof. The chewable confectionary can exhibit a polyphenolic content of at least 100 μg gallic acid equivalents (GAE) or greater, per gram of the chewable confectionary and an antioxidant capacity of at least 3,200 μM Trolox equivalents per gram of the chewable confectionary, as determined by the oxygen radical absorbance (ORAC) assay. Kits, methods of making and using the chewable confectionary are also disclosed. ## Claims ### Claim 1 A chewable confectionary, comprising: a chewable base; one or more unprocessed plant materials comprising a Cinnamomum sp. (cinnamon) dispersed throughout the chewable base, wherein the one or more unprocessed plant materials are grounded particulate materials and present in an amount greater than 0.5% by weight, based on the total weight of the chewable confectionary; and a low or non-caloric sweetener comprising allulose, wherein a ratio between the cinnamon and allulose is from 1:1 to 1:180; and wherein the chewable confectionary has an antioxidant capacity of at least 1,500 μM Trolox equivalents per gram of the chewable confectionary, as determined by the oxygen radical absorbance (ORAC) assay. ### Claim 2 (depends on 1) The chewable confectionary of claim 1, wherein the sweetener consists essentially of allulose. ### Claim 3 (depends on 1) The chewable confectionary of claim 1, wherein the allulose is present in an amount of from 10% to 60% by weight, based on the weight of the chewable confectionary. ### Claim 4 (depends on 1) The chewable confectionary of claim 1, comprising more than one unprocessed plant materials. ### Claim 5 (depends on 4) The chewable confectionary of claim 4, comprising plant materials from Myristica fragrans (nutmeg) and Pimenta dioica (allspice). ### Claim 6 (depends on 1) The chewable confectionary of claim 1, wherein the unprocessed plant materials comprise cinnamon present in an amount from 0.45% to 10% by weight, based on the weight of the chewable confectionary. ### Claim 7 (depends on 5) The chewable confectionary of claim 5, wherein the plant materials comprise nutmeg present in an amount from 0.45% to 10% by weight, based on the weight of the chewable confectionary. ### Claim 8 (depends on 5) The chewable confectionary of claim 5, wherein the plant materials comprise allspice present in an amount from 0.45% to 10% by weight, based on the weight of the chewable confectionary. ### Claim 9 (depends on 1) The chewable confectionary of claim 1, wherein the unprocessed plant materials have an average particle size from 0.4 mm to 1.5 mm. ### Claim 10 (depends on 1) The chewable confectionary of claim 1, having a polyphenolic content from 100 μg to 5 mg gallic acid equivalents (GAE) per gram of the chewable confectionary. ### Claim 11 (depends on 1) The chewable confectionary of claim 1, further comprising an unprocessed plant material selected from Rosimarinus officinalis (rosemary), Ocium basilicum (sweet basil), Salvia officinalis (sage), Origanum valgare(oregano), Origanum marjorana (marjoram), and Mentha peperita (mint), Laurel nobilis (bay leaves), Petroselium crispum (parsley), Syzygium aromaticum (clove), Hyssopus officinalis L. Var. angustifolius (hyssop), Thymus vulgaris L. (thyme), Camellia sinensis L. (tea), Allium sativum L. (garlic), Zingiber officinale (ginger), Papaveraceae spp., Citrus limon, Citrus sinensis, or Curcuma longa L. (turmeric). ### Claim 12 (depends on 1) The chewable confectionary of claim 1, further comprising a plasticizing agent, bulking agents, diluents, additional sweeteners, colorants, vitamins, probiotics, prebiotics, emulsifiers, flavoring agents, or a combination thereof. ### Claim 13 (depends on 1) The chewable confectionary of claim 1, wherein the chewable confectionary is selected from the group consisting of chewing gums and chewable tablets. ### Claim 14 (depends on 1) A chewing gum comprising the chewable confectionary of claim 1. ### Claim 15 (depends on 1) A method of making a chewable confectionary according to claim 1, comprising mixing a chewable base, one or more unprocessed plant materials comprising a Cinnamomum sp. to disperse the plant material throughout the chewable base, and a low or non-caloric sweetener comprising allulose, wherein a ratio between the cinnamon and allulose is from 1:1 to 1:180; and wherein the one or more unprocessed plant materials are grounded particulate materials and present in an amount greater than 0.5% by weight, based on the total weight of the chewable confectionary. ### Claim 16 (depends on 1) A method for treating, reducing or preventing oral oxidative stress in a subject comprising consuming a chewable confectionary according to claim 1, wherein antioxidants in the chewable confectionary are present in a therapeutically effective amount to treat, reduce or prevent oral oxidative stress in a subject. ### Claim 17 (depends on 16) The method of claim 16, wherein the subject's saliva exhibits an increase in total antioxidant capacity of at least 10% in Trolox equivalents per gram of the chewable confectionary after an oral residence time of greater than one minute, as determined by the oxygen radical absorbance (ORAC) assay, compared to the subject's saliva prior to chewing the chewable confectionary. ### Claim 18 (depends on 16) The method of claim 16, wherein the chewable confectionary is consumed at least once per week. ### Claim 19 (depends on 16) The method of claim 16, wherein the chewable confectionary is consumed in combination with an additional therapeutic agent for treating, reducing or preventing oxidative stress. ### Claim 20 (depends on 1) A kit comprising at least three chewable confectionaries according to claim 1. ### Claim 21 (depends on 20) The kit according to claim 20, wherein at least one of the chewable confectionary is a chewing gum. ### Claim 22 A chewable confectionary, comprising: a chewable base; one or more unprocessed plant materials comprising a phytochemical ingredient dispersed throughout the chewable base, wherein the one or more unprocessed plant materials are grounded particulate materials and present in an amount greater than 0.5% by weight, based on the total weight of the chewable confectionary; and a low or non-caloric sweetener comprising allulose, wherein a ratio between the cinnamon and allulose is from 1:1 to 1:180; and wherein the chewable confectionary has an antioxidant capacity of at least 1,500 μM Trolox equivalents per gram of the chewable confectionary, as determined by the oxygen radical absorbance (ORAC) assay.