# US 11,304,889 B2 · Oral care compositions and methods for increasing the stability of the same

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- Number: US 11,304,889 B2
- Document ID: US11304889B2
- Status: Granted
- Kind: B2
- Application number: 15/840,050
- Filed: 2017-12-13
- Published: 2018-06-21
- Granted: 2022-04-19
- Earliest claimed: 2016-12-20
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Shyamala Pillai; Guofeng Xu; LaTonya Kilpatrick-Liverman; Xiang Chen; Suman Chopra; Robert Dicosimo; Mark S. Payne; Mahmoud Hassan
- Web page: https://patentgrep.com/patent/US11304889B2

## CPC

- A61K 8/66: Enzymes
- A61C 19/066: {Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips}
- A61K 8/06: Emulsions
- A61K 8/22: Peroxides; Oxygen; Ozone
- A61K 8/31: Hydrocarbons
- A61K 8/37: Esters of carboxylic acids
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/442: {substituted by amido group(s)}
- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 8/8147: {Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers}
- A61K 8/817: {Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)}
- A61K 8/8176: {Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers}
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/48: Thickener, Thickening system
- A61K 2800/882: Mixing prior to application
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61C: DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE (non-driven toothbrushes A46B; {tongue scrapers A61B17/24;} preparations for dentistry A61K6/00; preparations for cleaning the teeth or mouth A61K8/00, A61Q11/00)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

An oral care composition including a hydrophobic phase and a hydrophilic phase is disclosed. The hydrophobic phase may include a source of hydrogen peroxide and an acyl donor, and the hydrophilic phase may include an enzyme having perhydrolytic activity that catalyzes the generation of peracetic acid between the source of hydrogen peroxide and the acyl donor.

## Claims

### Claim 1

An oral care composition, comprising:
a hydrophobic phase comprising a source of hydrogen peroxide and an acyl donor,
a hydrophilic phase comprising an enzyme that catalyzes the generation of peracetic acid between the source of hydrogen peroxide and the acyl donor;
wherein the enzyme comprises a CE-7 signature motif that aligns with SEQ ID NO: 2, the CE-7 signature motif comprising;
a) an RGQ motif at positions corresponding to positions 118-120 of SEQ ID NO: 2;
b) a GXSQG (SEQ ID NO: 3) motif at positions corresponding to positions 179-183 of SEQ ID NO: 2;
c) an HE motif at positions corresponding to positions 298-299 of SEQ ID NO:2.

### Claim 2 (depends on 1)

The oral care composition of claim 1, wherein the hydrophobic phase further comprises one or more adhesion enhancing agents, optionally the adhesion enhancing agent includes at least one of petrolatum and mineral oil.

### Claim 3 (depends on 1)

The oral care composition according to claim 1, wherein the acyl donor is selected from one or more of a C2-18 carboxylic acid, a hydrolysable ester, and mixtures thereof.

### Claim 4 (depends on 1)

The oral care composition according to claim 1, wherein the acyl donor is triacetin.

### Claim 5 (depends on 1)

The oral care composition according to claim 1, wherein the hydrophobic phase is substantially free of water.

### Claim 6 (depends on 1)

The oral care composition according to claim 1, wherein the hydrophobic phase further comprises a thickener, optionally the thickener is polyvinylpyrrolidone.

### Claim 7 (depends on 1)

The oral care composition according to claim 1, wherein the source of hydrogen peroxide is a cross-linked polyvinylpyrrolidone (PVP) hydrogen peroxide complex.

### Claim 8 (depends on 1)

The oral care composition according to claim 1, wherein the hydrophilic phase further comprises a thickener, optionally the thickener of the hydrophilic phase comprises a carboxyvinyl polymer.

### Claim 9 (depends on 1)

The oral care composition according to claim 1, wherein the hydrophilic phase further comprises at least one surfactant, optionally the surfactant is cocamidopropyl betaine.

### Claim 10 (depends on 1)

The oral care composition according to claim 1, wherein the enzyme has perhydrolytic activity and is configured to generate peracetic acid via enzyme-catalyzed perhydrolysis.

### Claim 11 (depends on 1)

The oral care composition according to claim 1, wherein the enzyme comprises an amino acid sequence having at least 80% amino acid sequence identity to SEQ ID NO: 1.

### Claim 12 (depends on 1)

A method for whitening teeth, comprising:
contacting the hydrophobic phase and the hydrophilic phase of the oral care composition of claim 1 with one another to form a mixture; and
generating peracetic acid from the mixture.

### Claim 13 (depends on 12)

The method of claim 12, further comprising:
disposing the mixture in a dental tray; and
disposing the dental tray about the teeth to contact the peracetic acid with surfaces of the teeth.

### Claim 14 (depends on 1)

The oral care composition according to claim 1, wherein the hydrophobic phase has a hydrophobicity of at least 4.0 log P.

### Claim 15 (depends on 1)

The oral care composition according to claim 1, wherein the hydrophobic phase has a hydrophobicity of at least 5.5 log P.