# US 11,304,880 B2 · Glass ionomer compositions and methods including water-miscible, silane-treated, nano-sized silica particles > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,304,880 B2 - Document ID: US11304880B2 - Status: Granted - Kind: B2 - Application number: 16/613,368 - Filed: 2018-05-09 - Published: 2020-03-05 - Granted: 2022-04-19 - Earliest claimed: 2017-05-18 - Assignees: 3M Innovative Properties Company - Applicants: 3M Innovative Properties Company - Inventors: Mark B. Agre; Bradley D. Craig; Michael Jahns; Adrian S. Eckert - Web page: https://patentgrep.com/patent/US11304880B2 ## CPC - A61K 6/889: Polycarboxylate cements; Glass ionomer cements - A61K 6/17: Particle size - A61K 6/54: Filling; Sealing - A61K 6/816: comprising titanium oxide - A61K 6/818: comprising zirconium oxide - A61K 6/831: comprising non-metallic elements or compounds thereof, e.g. carbon - C03C 3/062: with less than 40% silica by weight - C03C 4/0021: {for dental use} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - C03C: CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS ## Abstract Disclosed herein are curable glass ionomer compositions that include a first paste and a second paste, and methods for using the disclosed compositions. The first paste includes water, a polyacid, and a non acid-reactive filler. The second paste includes water, an acid-reactive filler; and non-aggregated, water-miscible, nano-sized silica particles having at least 25% surface coverage of the particles with a silane. The composition is essentially free of a resin. In some embodiments, the water content of the first paste and the second paste of the paste/paste GI composition disclosed herein is less than 20% by weight, based on the total weight of the composition. ## Claims ### Claim 1 A curable glass ionomer composition comprising: a first paste comprising: water, a polyacid, and a non acid-reactive filler; and a second paste comprising: water, an acid-reactive filler; and non-aggregated, water-miscible, nano-sized silica particles having at least 25% surface coverage of the particles with a silane; wherein the composition is essentially free of a resin. ### Claim 2 (depends on 1) The composition of claim 1, or wherein the silane is essentially free of unsaturated polymerizable groups. ### Claim 3 (depends on 1) The composition of claim 1, wherein the silane is represented by the formula: (R1O)3—Si—(CH2)n—(O—R2)x—OR3, wherein: R1 is a C1-C3 alkyl group; R2 is a C2-C3 alkylene group; R3 is a C1-C10 alkyl group or 2,3-epoxypropyl; n=2 to 6; and x=0 to 200. ### Claim 4 (depends on 3) The composition of claim 3, or wherein R2 represents —CH2CH2—. ### Claim 5 (depends on 3) The composition of claim 3, wherein n=3. ### Claim 6 (depends on 1) The composition of claim 1, wherein the non-aggregated, water-miscible, nano-sized silica particles are substantially free of fumed silica. ### Claim 7 (depends on 1) The composition of claim 1, wherein at least one of the first paste and the second paste further comprises pyrogenic silica particles. ### Claim 8 (depends on 1) The composition of claim 1, wherein the water content of the first paste and the second paste combined is less than 20% by weight, based on the total weight of the composition. ### Claim 9 (depends on 1) The composition of claim 1, wherein the non acid-reactive filler comprises particles and/or fibers. ### Claim 10 (depends on 1) The composition of claim 1, wherein the non acid-reactive filler is selected from the group consisting of quartz, nitrides, kaolin, borosilicate glass, strontium oxide based glass, barium oxide based glass, silica, alumina, titania, zirconia, and combinations thereof. ### Claim 11 (depends on 1) The composition of claim 1, wherein the non acid-reactive filler comprises substantially crystalline inorganic fibers. ### Claim 12 (depends on 11) The composition of claim 11, wherein the substantially crystalline inorganic fibers comprise ceramics and/or metal oxides. ### Claim 13 (depends on 11) The composition of claim 11, wherein the substantially crystalline inorganic fibers have a crystallinity index of at least 0.05 as measured by the XRD Crystallinity Index Test Method. ### Claim 14 (depends on 1) The composition of claim 1, wherein the acid-reactive filler comprises an inorganic filler selected from the group consisting of basic metal oxides, metal hydroxides, hydroxyapatite, aluminosilicate glasses, fluoroaluminosilicate glasses, glasses having a Si/Al weight percent ratio less than 1.5, and combinations thereof. ### Claim 15 (depends on 1) The composition of claim 1, wherein the acid-reactive filler has a mean particle size of 3 micrometers to 10 micrometers. ### Claim 16 (depends on 1) The composition of claim 1, wherein the first paste further comprises a complexing agent. ### Claim 17 (depends on 1) The composition of claim 1, wherein the composition remains sufficiently workable or mixable to form a curable glass ionomer composition after storage at room temperature for at least one month. ### Claim 18 (depends on 1) The composition of claim 1, wherein the composition remains sufficiently workable or mixable to form a curable glass ionomer composition after storage at room temperature for at least three months. ### Claim 19 (depends on 1) A method of preparing a cured composition comprising: providing a curable glass ionomer composition of claim 1; combining the first paste and the second paste to form a mixture; and allowing the mixture to cure to form the cured composition. ### Claim 20 (depends on 1) A device for storing a composition of claim 1, the device comprising: a first compartment containing the first paste; and a second compartment containing the second paste.