# US 11,304,854 B2 · Buffered adhesive compositions for skin-adhering medical products

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- Number: US 11,304,854 B2
- Document ID: US11304854B2
- Status: Granted
- Kind: B2
- Application number: 16/594,665
- Filed: 2019-10-07
- Published: 2020-01-30
- Granted: 2022-04-19
- Earliest claimed: 2012-02-29
- Assignees: Hollister Incorporated
- Applicants: Hollister Incorporated
- Inventors: Jan Wohlgemuth; Mette Maack; Carsten Rikhof; Peter Skov; Kristoffer Nielsen; Per Ladefoged; Kenneth Nielsen; Michael Taylor; Richard Murahata
- Web page: https://patentgrep.com/patent/US11304854B2

## CPC

- A61F 13/0253: {characterized by the adhesive material}
- A61F 5/443: having {adhesive seals for securing to the body, e.g. of} hydrocolloid type seals, e.g. gels, starches or karaya gums
- A61F 13/0203: with fluid retention members
- A61L 15/585: {Mixtures of macromolecular compounds}
- A61L 15/60: Liquid-swellable gel-forming materials, e.g. super-absorbents
- A61L 24/0031: {Hydrogels or hydrocolloids}
- A61L 24/043: {Mixtures of macromolecular materials}
- A61L 26/0052: {Mixtures of macromolecular compounds}
- A61L 26/008: {Hydrogels or hydrocolloids}
- C08L 23/18: Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
- C08L 33/02: Homopolymers or copolymers of acids; Metal or ammonium salts thereof
- C08L 53/02: of vinyl-aromatic monomers and conjugated dienes
- C09J 123/20: having four to nine carbon atoms
- C09J 123/22: Copolymers of isobutene; Butyl rubber {; Homo- or copolymers of other iso-olefines}
- C09J 133/02: Homopolymers or copolymers of acids; Metal or ammonium salts thereof
- C08L 2205/16: Fibres; Fibrils
- C08L 2205/22: Mixtures comprising a continuous polymer matrix in which are dispersed crosslinked particles of another polymer
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)
- C09J: ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES (preparation of glue or gelatine C09H)

## Abstract

Provided are buffered adhesive compositions comprising a high molecular weight non-neutralized polymeric acid and a high molecular weight partially neutralized polymeric acid and products such as wound dressings and ostomy skin barriers incorporating the compositions.

## Claims

### Claim 1

An ostomy skin barrier comprising:
a first adhesive that includes a polymeric buffer composition;
a second adhesive, that includes a hydrocolloid; and
wherein the first adhesive includes 40 wt. % of polyisobutylene, 16 wt. % of styrene-isoprene-styrene copolymer, 5 wt. % of liquid PIB, 4 wt. % of polyethylene fibers, 20 wt. % of cross linked polyacrylic acid, and 15 wt. % of cross linked partially neutralized polyacrylic acid.

### Claim 2 (depends on 1)

The ostomy skin barrier of claim 1, wherein the second adhesive has a lower absorptive capacity than the first adhesive.

### Claim 3 (depends on 1)

The ostomy skin barrier of claim 1, wherein the second adhesive includes 55.5 wt. % polyisobutylene, 14.5 wt. % of styrene-isoprene-styrene copolymer, 5 wt. % of polyethylene fibers, 8.3 wt. % of pectin, and 16.7 wt. % of CMC.

### Claim 4

An ostomy skin barrier comprising:
a first barrier surface having a first adhesive that includes a polymeric buffer composition; and
a second barrier surface having a second adhesive includes a hydrocolloid; and
wherein the first adhesive includes 40 wt. % of polyisobutylene, 16 wt. % of styrene-isoprene-styrene copolymer, 5 wt. % of liquid PIB, 4 wt. % of polyethylene fibers, 20 wt. % of cross linked polyacrylic acid, and 15 wt. % of cross linked partially neutralized polyacrylic acid.

### Claim 5 (depends on 4)

The ostomy skin barrier of claim 4, wherein the first barrier surface is an inner layer formed from the first adhesive and the second barrier surface is a backing layer formed from the second adhesive, wherein the backing layer extends over and beyond the inner layer to form an edge portion of the barrier.

### Claim 6 (depends on 4)

The ostomy skin barrier of claim 4, wherein the first barrier surface is configured to contact a peristomal area that is immediately adjacent to a wearer's stoma.

### Claim 7 (depends on 5)

The ostomy skin barrier of claim 5, wherein the second adhesive has a lower absorptive capacity than the first adhesive reducing the likelihood that the edge portion will undesirably swell when contacted with a fluid.

### Claim 8 (depends on 4)

The ostomy skin barrier of claim 4, wherein the first barrier surface includes a release layer.

### Claim 9

A wound dressing comprising:
a flexible outer layer;
a first adhesive that includes a polymeric buffer composition
a second adhesive that includes a hydrocolloid; and
wherein the first adhesive includes 40 wt. % of polyisobutylene, 16 wt. % of styrene-isoprene-styrene copolymer, 5 wt. % of liquid PIB, 4 wt. % of polyethylene fibers, 20 wt. % of cross linked polyacrylic acid, and 15 wt. % of cross linked partially neutralized polyacrylic acid; and
wherein the first and second adhesives are applied to a side of the flexible outer layer.

### Claim 10 (depends on 9)

The wound dressing of claim 9, wherein the second adhesive has a lower absorptive capacity than the first adhesive.

### Claim 11

A method of manufacturing an ostomy skin barrier comprising the steps of:
forming a first adhesive into a first barrier surface, the first adhesive including a polymeric buffer composition; and
forming a second adhesive that includes a hydrocolloid; and
wherein the first adhesive includes 40 wt. % of polyisobutylene, 16 wt. % of styrene-isoprene-styrene copolymer, 5 wt. % of liquid PIB, 4 wt. % of polyethylene fibers, 20 wt. % of cross linked polyacrylic acid, and 15 wt. % of cross linked partially neutralized polyacrylic acid.

### Claim 12 (depends on 11)

The method of claim 11, wherein the first adhesive has a higher absorptive capacity than the second adhesive.