# US 11,304,852 B2 · Hemostatic textile

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- Number: US 11,304,852 B2
- Document ID: US11304852B2
- Status: Granted
- Kind: B2
- Application number: 16/111,362
- Filed: 2018-08-24
- Published: 2018-12-20
- Granted: 2022-04-19
- Earliest claimed: 2006-01-11
- Assignees: The University of North Carolina at Chapel Hill; Eniegrion Inc
- Applicants: The University of North Carolina at Chapel Hill; Entegrion, Inc.
- Inventors: Thomas H. Fischer; E. Stan Eskridge; William M. Malloy; Malloy Evans
- Web page: https://patentgrep.com/patent/US11304852B2

## CPC

- A61F 13/01042: {Absorbency}
- A61F 13/00063: {comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic (drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00)}
- A61F 13/00072: {Packaging of dressings}
- A61F 13/00991: {for treating webs, e.g. for moisturising, coating, impregnating or applying powder}
- A61F 13/01012: {being made of natural material, e.g. cellulose-, protein-, collagen-based}
- A61F 13/01017: {synthetic, e.g. polymer based}
- A61L 15/16: Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L 15/18: containing inorganic materials
- A61L 15/20: containing organic materials
- A61L 15/28: Polysaccharides or their derivatives {(A61L15/225 takes precedence)}
- A61L 15/42: Use of materials characterised by their function or physical properties (liquid bandages A61L26/00)
- A61P 7/04: Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A61F 2013/00089: {Wound bandages (A61F2013/00361 takes precedence;)}
- A61F 2013/00463: {haemostatic}
- A61K 36/899: Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61L 2400/04: Materials for stopping bleeding
- C08K 7/14: Glass
- D02G 3/18: from glass or the like
- Y10T 442/30: Woven fabric [i.e., woven strand or strip material]
- Y10T 442/40: Knit fabric [i.e., knit strand or strip material]
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C08K: Use of inorganic or non-macromolecular organic substances as compounding ingredients (paints, inks, varnishes, dyes, polishes, adhesives C09)
- D02G: CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyimide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.

## Claims

### Claim 1

A packaged hemostatic textile comprising:
a textile material comprising glass fibers cowoven or knitted with bamboo rayon fibers, wherein when the textile material is in contact with a wound on an animal or human, hemostatic systems are activated in the animal or human, and wherein the textile material is packaged in a sterilized package.

### Claim 2 (depends on 1)

The packaged hemostatic textile of claim 1, wherein the glass fibers comprise continuous glass fibers.

### Claim 3 (depends on 1)

The packaged hemostatic textile of claim 1, wherein the glass fibers have a diameter of between 5 nanometers and 15 microns.

### Claim 4 (depends on 1)

The packaged hemostatic textile of claim 1, wherein the textile material comprises thrombin or a fraction containing thrombin.

### Claim 5 (depends on 1)

The packaged hemostatic textile of claim 1, wherein the textile material comprises a hemostatic agent selected from the group consisting of rehydrated lyophilized platelets, rehydrated lyophilized blood cells, fibrin, fibrinogen, and combinations thereof.

### Claim 6

A packaged hemostatic textile comprising:
a woven or knitted textile material that activates hemostatic systems in an animal or human when the textile material is in contact with a wound on the animal or human, wherein the woven or knitted textile material is packaged in a sterilized package, wherein the textile comprises bamboo rayon fibers.

### Claim 7 (depends on 6)

The packaged hemostatic textile of claim 6, wherein the textile material comprises thrombin or a fraction containing thrombin.

### Claim 8 (depends on 6)

The packaged hemostatic textile of claim 6, wherein the textile material comprises a hemostatic agent selected from the group consisting of rehydrated lyophilized platelets, rehydrated lyophilized blood cells, fibrin, fibrinogen, and combinations thereof.

### Claim 9 (depends on 6)

The packaged hemostatic textile of claim 6, wherein the textile material comprises glass fibers.

### Claim 10

A hemostatic textile comprising:
glass fibers cowoven or knitted with bamboo rayon fibers, wherein when the hemostatic textile is in contact with a wound on an animal or human, hemostatic systems are activated in the animal or human.

### Claim 11 (depends on 10)

The hemostatic textile of claim 10, wherein the glass fibers comprise continuous glass fibers.

### Claim 12 (depends on 10)

The hemostatic textile of claim 10, comprising thrombin or a fraction containing thrombin.

### Claim 13 (depends on 10)

The hemostatic textile of claim 10, comprising a hemostatic agent selected from the group consisting of rehydrated lyophilized platelets, rehydrated lyophilized blood cells, fibrin, fibrinogen, and combinations thereof.

### Claim 14 (depends on 10)

The hemostatic textile of claim 10, wherein the glass fibers have a diameter of between 5 nanometers and 15 microns.

### Claim 15 (depends on 10)

The hemostatic textile of claim 10, wherein the glass fibers comprise aluminoborosilicate glass.