# US 11,304,665 B2 · Computation of hemodynamic quantities from angiographic data

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- Number: US 11,304,665 B2
- Document ID: US11304665B2
- Status: Granted
- Kind: B2
- Application number: 16/161,558
- Filed: 2018-10-16
- Published: 2019-02-14
- Granted: 2022-04-19
- Earliest claimed: 2012-07-09
- Assignees: Siemens Healthcare GmbH
- Applicants: Siemens Healthcare GmbH
- Inventors: Puneet Sharma; Saikiran Rapaka; Xudong Zheng; Ali Kamen; Lucian Mihai Itu; Bogdan Georgescu; Dorin Comaniciu; Thomas Redel; Jan Boese; Viorel Mihalef
- Web page: https://patentgrep.com/patent/US11304665B2

## CPC

- A61B 5/7278: {Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals}
- A61B 5/02007: {Evaluating blood vessel condition, e.g. elasticity, compliance}
- A61B 5/02028: {Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction}
- A61B 5/021: Measuring pressure in heart or blood vessels
- A61B 5/026: Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)}
- A61B 6/481: {involving the use of contrast agents}
- A61B 6/504: {for diagnosis of blood vessels, e.g. by angiography}
- A61B 6/507: {for determination of haemodynamic parameters, e.g. perfusion CT}
- A61B 6/5217: {extracting a diagnostic or physiological parameter from medical diagnostic data}
- G16H 50/30: for calculating health indices; for individual health risk assessment
- G16Z 99/00: Subject matter not provided for in other main groups of this subclass
- A61B 34/10: Computer-aided planning, simulation or modelling of surgical operations
- A61B 2090/3762: {using computed tomography systems [CT]}
- A61B 2560/0475: Special features of memory means, e.g. removable memory cards
- G16H 50/50: for simulation or modelling of medical disorders
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16Z: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR

## Abstract

Methods for computing hemodynamic quantities include: (a) acquiring angiography data from a patient; (b) calculating a flow and/or calculating a change in pressure in a blood vessel of the patient based on the angiography data; and (c) computing the hemodynamic quantity based on the flow and/or the change in pressure. Systems for computing hemodynamic quantities and computer readable storage media are described.

## Claims

### Claim 1

A method for computing a hemodynamic quantity, the method comprising:
acquiring angiography data from a patient;
calculating, by a processor, a first flow in a blood vessel with a stenosis based on the angiography data;
calculating a plurality of second flows in the blood vessel, wherein calculating the first flow comprises calculating by motion tracking contrast agents represented in the angiography data, and wherein calculating the plurality of second flows comprises iteratively calculating the plurality of second flows from the first flow;
computing, by the processor, a baseline fractional flow reserve value from the first flow and the stenosis;
computing, by the processor, fractional flow reserve values from the plurality of second flows;
determining a sensitivity of the fractional flow reserve values to a difference between the first flow and the plurality of second flows relative to the baseline fractional reserve value; and
reporting the sensitivity.

### Claim 2 (depends on 1)

The method of claim 1 wherein computing comprises computing with a computational fluid dynamics model.

### Claim 3 (depends on 1)

The method of claim 1 wherein the first flow comprises flow from artificially generated stenoses.

### Claim 4 (depends on 1)

The method of claim 1 wherein calculating the first flow comprises calculating a third flow for a rest state, and calculating the first flow as a multiplication of the third flow by a flow rate scalar from the rest state to a hyperemic state, wherein the flow rate scalar comprises a rest-to-hyperemic flow rate ratio.

### Claim 5

A method for computing a hemodynamic quantity, the method comprising:
acquiring angiography data from a patient;
calculating, by a processor, a first flow in a blood vessel with a stenosis based on the angiography data;
calculating a plurality of second flows in the blood vessel, wherein calculating the plurality of second flows comprises calculating by motion tracking contrast agents representing in the angiography data, and wherein calculating the plurality of second flows comprises iteratively calculating the plurality of second flows from the first flow;
computing, by the processor, a baseline value of a hemodynamic quantity from the first flow and the stenosis;
computing, by the processor, values for the hemodynamic quantity from the plurality of second flows;
determining a sensitivity of the values of the hemodynamic quantity to a difference between the first flow and the plurality of second flows relative to the baseline value of the hemodynamic quantity; and
reporting the sensitivity.

### Claim 6 (depends on 5)

The method of claim 5 wherein the hemodynamic quantity comprises a fractional flow reserve.

### Claim 7 (depends on 5)

The method of claim 5 wherein computing comprises computing with a computational fluid dynamics model.

### Claim 8 (depends on 5)

The method of claim 5 wherein the first flow comprises flow from artificially generated stenoses.

### Claim 9 (depends on 5)

The method of claim 5 wherein calculating the first flow comprises calculating a third flow for a rest state, and calculating the first flow as a multiplication of the third flow by a flow rate scalar from the rest state to a hyperemic state, wherein the flow rate scalar comprises a rest-to-hyperemic flow rate ratio.

### Claim 10

A method for computing a hemodynamic quantity, the method comprising:
acquiring angiography data from a patient;
iteratively calculating, by a processor, a first flow in a blood vessel with a stenosis;
calculating a plurality of second flows in the blood vessel, wherein calculating the plurality of second flows comprises calculating by motion tracking contrast agents representing in the angiography data, and wherein calculating the plurality of second flows comprises iteratively calculating the plurality of second flows from the first flow;
computing, by the processor, a baseline fractional flow reserve value from the first flow and the stenosis;
computing, by the processor, fractional flow reserve values from the plurality of second flows;
determining a sensitivity of the fractional flow reserve values to a difference between the first flow and the plurality of second flows relative to the baseline fractional reserve value; and
reporting the sensitivity.

### Claim 11 (depends on 10)

The method of claim 10 wherein calculating the first flow comprises calculating a third flow for a rest state, and calculating the first flow as a multiplication of the third flow by a flow rate scalar from the rest state to a hyperemic state, wherein the flow rate scalar comprises a rest-to-hyperemic flow rate ratio.