# US 11,304,601 B2 · Methods and kits for assessing central nervous system integrity

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- Number: US 11,304,601 B2
- Document ID: US11304601B2
- Status: Granted
- Kind: B2
- Application number: 16/260,379
- Filed: 2019-01-29
- Published: 2019-05-23
- Granted: 2022-04-19
- Earliest claimed: 2012-03-26
- Assignees: New York University; The United States of America as represented by the Department of Veterans Affairs
- Applicants: New York University; The United States Government AS Represented By the Department of Veterans Affairs
- Inventors: Uzma Samadani; Shani Offen; Marisa Carrasco-Queijeiro; David Heeger
- Web page: https://patentgrep.com/patent/US11304601B2

## CPC

- A61B 3/113: for determining or recording eye movement
- A61B 3/0025: {characterised by electronic signal processing, e.g. eye models}
- A61B 5/031: {Intracranial pressure}
- A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)}
- A61B 5/4076: {Diagnosing or monitoring particular conditions of the nervous system}
- A61B 5/7246: {using correlation, e.g. template matching or determination of similarity}
- A61B 5/7264: {Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems}
- A61B 3/024: for determining the visual field, e.g. perimeter types
- A61B 5/7275: {Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor}
- G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction or associated cranial nucleus or supranuclear input, useful for detecting, diagnosing or screening for increased intracranial pressure, or useful for detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure by tracking eye movement of the subject. The methods may be performed by a) analyzing eye movement of the subject; b) comparing eye movement of the subject to eye movement of a control or the subject's own baseline eye movement; and c) identifying the subject as having eye movement significantly different from the control or the subject's own baseline eye movement.

## Claims

### Claim 1

A method for detecting or screening for reduced or impaired cranial nerve function or conduction in a subject, comprising:
a) tracking an eye movement of the subject using an eye tracker having a camera;
b) creating a dataset of the eye movement of the subject via a processor;
c) generating a plot of the dataset on a display, the plot reflecting a timecourse of eye position versus time;
d) identifying one or more streaking vertical lines in the plot to indicate a deficit in cranial nerve II function; and
e) prescribing a treatment including at least one of an antibiotic, a steroid or a surgical treatment if a deficit in cranial nerve II function is identified.

### Claim 2 (depends on 1)

The method according to claim 1, further comprising obtaining at least 100,000 samples of eye position.

### Claim 3 (depends on 1)

The method according to claim 1 wherein eye movement is tracked in response to a visual stimulus.

### Claim 4 (depends on 1)

The method according to claim 1, further comprising tracking the eye movement for a period of from 30 to 500 seconds.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the deficit in cranial nerve II function relates to multiple sclerosis.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the deficit in cranial nerve II function relates to a trauma.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the deficit in cranial nerve II function relates to a subdural hematoma.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the one or more streaking vertical lines are indicative of scanning vision.

### Claim 9

A method of screening for multiple sclerosis in a subject, comprising:
a) tracking an eye movement of the subject using an eye tracker having a camera;
b) creating a dataset of the eye movement of the subject via a processor;
c) generating a plot of the dataset on a display, the plot reflecting a timecourse of eye position versus time;
d) identifying one or more streaking vertical lines in the plot to indicate a deficit in cranial nerve II function; and
e) prescribing a treatment including at least one of an antibiotic, a steroid or a surgical treatment if a deficit in cranial nerve II function is identified.