# US 11,304,420 B2 · Anti-viral paints and coatings and articles comprising same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,304,420 B2 - Document ID: US11304420B2 - Status: Granted - Kind: B2 - Application number: 17/378,585 - Filed: 2021-07-16 - Published: 2021-11-18 - Granted: 2022-04-19 - Earliest claimed: 2019-02-03 - Assignees: Reactive Surfaces Ltd., LLP - Applicants: Reactive Surfaces Ltd., LLP - Inventors: Claude Steven McDaniel - Web page: https://patentgrep.com/patent/US11304420B2 ## CPC - A01N 63/40: Viruses, e.g. bacteriophages - C09D 5/14: Paints containing biocides, e.g. fungicides, insecticides or pesticides (C09D5/16 takes precedence) - A01N 25/10: Macromolecular compounds - A01N 63/50: Isolated enzymes; Isolated proteins (peptides A01N37/46) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D) ## Abstract Disclosed herein are material composition formulated for mitigating activity of a virus on a surface of an article. Methods of preparing such a material composition are also disclosed. ## Claims ### Claim 1 A method for mitigating contamination of a surface by particles of at least a coronavirus for which an enveloped bacterial virus having a lipid-rich viral membrane envelope is a biological surrogate, comprising: applying an anti-viral functionalized coating composition on a surface of a substrate to create an anti-viral functionalized surface thereof, wherein the anti-viral functionalized coating composition comprises an effective amount of an anti-viral additive admixed with a specified amount of a polymeric coating composition, wherein the anti-viral additive comprises antimicrobial peptide and lipolytic enzyme, wherein said antimicrobial peptide comprises SEQ ID NO. 40, wherein the effective amount of said antimicrobial peptide and the specified amount of said lipolytic enzyme jointly cause the anti-viral functionalized surface to provide an additive-induced amount of infective particles of the biological surrogate when the biological surrogate is brought into contact with the anti-viral functionalized surface that is at least 70% less than a baseline amount of infective particles of the biological surrogate, wherein a surface of a layer of the polymeric coating composition on the surface of the substrate supports presence of the baseline amount of infective particles of the biological surrogate when the biological surrogate is brought into contact with the surface of the layer of the polymeric coating composition. ### Claim 2 (depends on 1) The method of claim 1 wherein the infective particles of the biological surrogate are infective PHI-6 bacteriophage particles. ### Claim 3 (depends on 1) The method of claim 1 wherein said lipolytic enzyme comprises lipase. ### Claim 4 (depends on 3) The method of claim 3 wherein the anti-viral functionalized coating composition provides an additive-induced amount of infective particles of the biological surrogate brought into contact with the anti-viral functionalized surface that is at least 80% less than the baseline amount of infective particles of the biological surrogate. ### Claim 5 (depends on 4) The method of claim 4 wherein the infective particles of the biological surrogate are infective PHI-6 bacteriophage particles. ### Claim 6 (depends on 3) The method of claim 3 wherein: said antimicrobial peptide is present within the polymeric coating composition at a concentration of about 3% total solids; and said lipolytic enzyme is present within the polymeric coating composition at a concentration of about 1.5% total solids. ### Claim 7 (depends on 6) The method of claim 6 wherein: said antimicrobial peptide consists of SEQ ID NO. 40; and said lipolytic enzyme consists of lipase. ### Claim 8 (depends on 1) The method of claim 1 wherein: the infective particles of the biological surrogate are infective PHI-6 bacteriophage particles; and said lipolytic enzyme comprises lipase. ### Claim 9 (depends on 8) The method of claim 8 wherein the polymeric coating composition comprises water-based polyurethane. ### Claim 10 (depends on 8) The method of claim 8 wherein: said antimicrobial peptide is present within the polymeric coating composition at a concentration of about 3% total solids; and said lipolytic enzyme is present within the polymeric coating composition at a concentration of about 1.5% total solids. ### Claim 11 (depends on 10) The method of claim 10 wherein the anti-viral functionalized coating composition provides an additive-induced amount of infective particles of the biological surrogate brought into contact with the anti-viral functionalized surface that is at least 80% less than the baseline amount of infective particles of the biological surrogate. ### Claim 12 (depends on 1) The method of claim 1 wherein the polymeric coating composition comprises water-based polyurethane. ### Claim 13 (depends on 12) The method of claim 12 wherein said lipolytic enzyme comprises lipase. ### Claim 14 (depends on 13) The method of claim 13 wherein the infective particles of the biological surrogate are infective PHI-6 bacteriophage particles. ### Claim 15 (depends on 12) The method of claim 12 wherein the anti-viral functionalized coating composition provides an additive-induced amount of infective particles of the biological surrogate brought into contact with the anti-viral functionalized surface that is at least 80% less than the baseline amount of infective particles of the biological surrogate. ### Claim 16 (depends on 12) The method of claim 12 wherein: said antimicrobial peptide is present within the polymeric coating composition at a concentration of about 3% total solids; and said lipolytic enzyme is present within the polymeric coating composition at a concentration of about 1.5% total solids. ### Claim 17 (depends on 16) The method of claim 16 wherein said lipolytic enzyme comprises lipase. ### Claim 18 (depends on 16) The method of claim 16 wherein: said antimicrobial peptide consists of SEQ ID NO. 40; and said lipolytic enzyme consists of lipase. ### Claim 19 (depends on 1) The method of claim 1 wherein the polymeric coating composition comprises an oil-modified polyurethane dispersion resin. ### Claim 20 (depends on 19) The method of claim 19 wherein said lipolytic enzyme comprises lipase. ### Claim 21 (depends on 20) The method of claim 20 wherein the infective particles of the biological surrogate are infective PHI-6 bacteriophage particles. ### Claim 22 (depends on 19) The method of claim 19 wherein the anti-viral functionalized coating composition provides an additive-induced amount of infective particles of the biological surrogate brought into contact with the anti-viral functionalized surface that is at least 80% less than the baseline amount of infective particles of the biological surrogate. ### Claim 23 A method for mitigating contamination of a surface by particles of at least a coronavirus for which an enveloped bacterial virus having a lipid-rich viral membrane envelope is a biological surrogate, comprising: forming a layer of an anti-viral functionalized coating composition on a surface of a substrate to create an anti-viral functionalized surface, wherein the anti-viral functionalized coating composition comprises an effective amount of an anti-viral additive admixed with a specified amount of a polymeric coating composition, wherein the anti-viral additive comprises antimicrobial peptide and lipolytic enzyme, wherein said antimicrobial peptide comprises SEQ ID NO. 40, wherein the effective amount of said antimicrobial peptide and the specified amount of said lipolytic enzyme jointly cause the anti-viral functionalized surface to provide an additive-induced amount of infective particles of the biological surrogate when the biological surrogate is brought into contact with the anti-viral functionalized surface that is at least 70% less than a baseline amount of infective particles of the biological surrogate, wherein a surface of a layer of the polymeric coating composition on the substrate supports presence of the baseline amount of infective particles of the biological surrogate when the biological surrogate is brought into contact with the surface of the layer of the polymeric coating composition. ### Claim 24 (depends on 23) The method of claim 23 wherein said lipolytic enzyme comprises lipase. ### Claim 25 (depends on 23) The method of claim 23 wherein: said antimicrobial peptide consists of SEQ ID NO. 40; and said lipolytic enzyme consists of lipase.