# US 11,299,784 B2 · Biomarkers for predicting degree of weight loss

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- Number: US 11,299,784 B2
- Document ID: US11299784B2
- Status: Granted
- Kind: B2
- Application number: 16/304,758
- Filed: 2017-05-30
- Published: 2019-10-31
- Granted: 2022-04-12
- Earliest claimed: 2016-05-31
- Assignees: Societe des Produits Nestle S.A.
- Applicants: Nestec S.A.
- Inventors: Armand Valesia; Jorg Hager; Jerome Carayol
- Web page: https://patentgrep.com/patent/US11299784B2

## CPC

- C12Q 1/6883: for diseases caused by alterations of genetic material
- G16B 5/00: ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
- G16B 20/20: Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
- G16B 40/10: Signal processing, e.g. from mass spectrometry [MS] or from PCR
- G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems
- G16H 50/30: for calculating health indices; for individual health risk assessment
- G16H 50/70: for mining of medical data, e.g. analysing previous cases of other patients
- C12Q 2600/156: Polymorphic or mutational markers
- C12Q 2600/158: Expression markers
- C12Q 2600/178: miRNA, siRNA or ncRNA
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- G16B: BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

The present invention relates to a method for predicting the degree of weight loss attainable by applying one or more dietary interventions to a subject and/or the degree of maintenance of weight loss following one or more dietary interventions; which method comprises determining the level of microRNA-486 (miR-486) in one or more samples obtained from the subject; and/or determining the nucleotide of the subject at one or more polymorphic positions genetically linked to miR-486.

## Claims

### Claim 1

A method for weight loss in a human, the method comprising:
(a) determining a presence of Guanine (G) at position 26 of SEQ ID NO: 3 (rs545936) of the human; and
(b) administering a dietary intervention to the human having a G at position 26 of SEQ ID NO: 3 (rs545936), wherein the dietary intervention comprises a low calorie diet comprising a calorie intake of 600-1200 kcal/day for a duration of 4 weeks to 16 weeks.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the method further comprises determining one or more anthropometric measures and/or lifestyle characteristics of the subject.

### Claim 3

A method for improvement in glycemic control in a human, the method comprising:
(a) determining a presence of Guanine (G) at position 26 of SEQ ID NO: 3 (rs545936) of the human; and
(b) administering a dietary intervention to the human having a G at position 26 of SEQ ID NO: 3 (rs545936), wherein the dietary intervention comprises a low calorie diet comprising a calorie intake of 600-1200 kcal/day for a duration of 4 weeks to 16 weeks.