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US 11,299,529 B2Granted
Chimeric antigen receptors
AssigneeAGC Biologics S.p.A.
InventorsAttilio Bondanza, Monica Casucci, Maria Chiara Bonini
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Abstract
A chimeric antigen receptor (CAR) comprising an extracellular spacer which comprises at least part of the extracellular domain of human low affinity nerve growth factor (LNGFR) or a derivative thereof.
Claims19
A chimeric antigen receptor (CAR) comprising:
- (i) an antigen-specific targeting domain which targets an antigen selected from the group consisting of isoform 6 of CD44 (CD44v6), CD19, and CEA;
- (ii) an extracellular spacer which comprises at least part of the extracellular domain of human low affinity nerve growth factor receptor (LNGFR), wherein said at least part of the LNGFR is suitable for facilitating immunoselection and identification of cells transduced with said CAR, wherein the extracellular spacer comprises the first three TNFR-Cys domains of LNGFR;
- (iii) a transmembrane domain;
- and
- (iv) an intracellular signaling domain.
2 more elements
A chimeric antigen receptor (CAR) comprising:
- (i) an antigen-specific targeting means for targeting a tumour antigen selected from the group consisting of CD44v6, CD19, CEA, and combinations thereof;
- (ii) an extracellular spacer which comprises at least part of the extracellular domain of human low affinity nerve growth factor receptor (LNGFR), wherein said at least part of the LNGFR is suitable for facilitating immunoselection and identification of cells transduced with said CAR, wherein the extracellular spacer comprises the first three TNFR-Cys domains of LNGFR;
- (iii) a transmembrane domain;
- and
- (iv) an intracellular signalling domain.
2 more elements
Dependencies are inferred from the claim text.