Benzenesulfonamide compounds and their use as therapeutic agents

A method of treating a disease or a condition associated with aberrant Nav1.6 activity in a patient, wherein the disease or condition is epilepsy or epileptic seizure disorder, comprising administering to the patient a therapeutically effective amount of a compound of the following formula:

• wherein:
• R1 is an optionally substituted phenyl or optionally substituted pyridyl;
• R2 is an optionally substituted thiazolyl, an optionally substituted thiadiazolyl, an optionally substituted isothiazolyl, or an optionally substituted pyridinyl;
• R3 is —O— or —N(R13)—;
• R4, R5, and R13 are each independently selected from hydrogen, alkyl, and haloalkyl;
• each R6 is independently selected from hydrogen, halo, alkyl, and haloalkyl;
• R7 is halo;
• each R8 is independently selected from hydrogen, alkyl, and haloalkyl;
• m is 1 or 2;
• and
• n is 1 or 2;
• as an individual stereoisomer, enantiomer or tautomer thereof or a mixture thereof;
• or a pharmaceutically acceptable salt or solvate thereof.