# US 11,298,855 B2 · Method for manufacturing hyaluronate film, and hyaluronate film manufactured thereby

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- Number: US 11,298,855 B2
- Document ID: US11298855B2
- Status: Granted
- Kind: B2
- Application number: 16/491,054
- Filed: 2018-03-07
- Published: 2020-01-16
- Granted: 2022-04-12
- Earliest claimed: 2017-03-07
- Assignees: Jinwoo Bio Co., Ltd.
- Applicants: Jinwoo Bio Co., Ltd.
- Inventors: Dong Keon Kweon; Joo Yeon Hong; Ji Hyun Bang; Seung Taik Lim; So Mang Choi; Seul Ki Kim; Man Ha; Young Mo Lee
- Web page: https://patentgrep.com/patent/US11298855B2

## CPC

- B29C 39/003: {characterised by the choice of material}
- A61L 27/20: Polysaccharides
- A61L 27/60: Materials for use in artificial skin
- A61L 31/04: Macromolecular materials
- B29C 39/00: Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor (B29C41/00 takes precedence)
- B29C 39/02: for making articles of definite length, i.e. discrete articles
- B29C 39/04: using movable moulds (B29C41/02 takes precedence){not applied}
- B29C 39/24: Feeding the material into the mould
- B29C 39/42: Casting under special conditions, e.g. vacuum
- C08J 5/18: Manufacture of films or sheets
- C08L 5/08: Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
- B29C 2791/005: Using a particular environment, e.g. sterile fluids other than air
- B29D 7/01: Films or sheets
- B29K 2005/00: Use of polysaccharides or derivatives as moulding material
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)
- B29D: PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE (making granules B29B9/00; making preforms B29B11/00)
- B29K: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR {MOULDS, } REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS

## Abstract

The present invention relates to a method of manufacturing a hyaluronate film and a hyaluronate film manufactured thereby, and more particularly to a method of manufacturing a hyaluronate film through a solvent-casting process or using an automatic film applicator that facilitates mass production and to a hyaluronate film manufactured thereby, which is useful as a mask pack for cosmetics, a patch for medicaments and medical devices, a film-type adhesion inhibitor, etc. Unlike conventional liquid products, the hyaluronate film according to the present invention has a dry surface and thus entails no concern about microbial contamination, is easy to produce/manage/distribute/use, and has superior mechanical properties, whereby it can be utilized for various applications such as packs, patches, artificial skin and the like for cosmetics, medicaments, and medical devices.

## Claims

### Claim 1

A method of manufacturing a hyaluronate film through a solvent-casting process, the method comprising:
(a) preparing a 0.1 to 30 wt % hyaluronate solution by dissolving hyaluronate having a molecular weight of 0.1 to 2.5 MDa in a 5 to 29 vol % ethanol aqueous solution; and
(b) placing the hyaluronate solution in a mold and drying the hyaluronate solution using a constant-temperature and constant-humidity chamber under conditions of a relative humidity of 30 to 70% and a drying temperature of 30 to 50° C.

### Claim 2

A method of manufacturing a hyaluronate film using an automatic film applicator, the method comprising:
(a) preparing a hyaluronate solution having a viscosity of 300 to 100,000 cPs at 25° C. and containing 0.1 to 30 wt % hyaluronate by dissolving the hyaluronate in a 5 to 29 vol % ethanol aqueous solution;
(b) placing the hyaluronate solution in an automatic film applicator and casting a film to a thickness of 0.025 to 5 mm; and
(c) drying the cast film at 30 to 50° C.