# US 11,298,567 B2 · Treatment plan evaluation tool

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,298,567 B2
- Document ID: US11298567B2
- Status: Granted
- Kind: B2
- Application number: 16/096,317
- Filed: 2017-04-17
- Published: 2019-05-02
- Granted: 2022-04-12
- Earliest claimed: 2016-04-28
- Assignees: Koninklijke Philips N.V.
- Applicants: Koninklijke Philips N.V.
- Inventors: Erkki Tapani Vahala; Lizette Warner; Kumar Raja Gattamaneni
- Web page: https://patentgrep.com/patent/US11298567B2

## CPC

- A61N 5/1075: {for testing, calibrating, or quality assurance of the radiation treatment apparatus}
- A61N 5/1039: {using functional images, e.g. PET or MRI}
- G01R 33/4812: {MR combined with X-ray or computed tomography [CT]}
- G01R 33/56563: {caused by a distortion of the main magnetic field B0, e.g. temporal variation of the magnitude or spatial inhomogeneity of B0 (G01R33/56509, G01R33/56518, G01R33/56536 take precedence)}
- G01R 33/58: Calibration of imaging systems, e.g. using test probes {, Phantoms; Calibration objects or fiducial markers such as active or passive RF coils surrounding an MR active material}
- A61N 2005/1074: {Details of the control system, e.g. user interfaces}
- G01R 33/56536: {due to magnetic susceptibility variations}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12)

## Abstract

It is an object of the invention to improve quality assurance when using MRI images for radiotherapy treatment planning. This object is achieved by a treatment plan evaluation tool A configured for calculating a quality indicator for a radiotherapy treatment plan. The radiotherapy treatment plan originates from a planning image, wherein the planning image is an MRI image acquired under a presence of a main magnetic field having a magnetic field inhomogeneity. The treatment plan evaluation tool is further configured to receive information about the magnetic field inhomogeneity and the treatment plan evaluation tool is further configured to calculate the quality indicator based on the information about the magnetic field homogeneity.

## Claims

### Claim 1

A treatment plan evaluation tool comprising a processor and/or controller configured for calculating a quality indicator for a radiotherapy treatment plan,
wherein the radiotherapy treatment plan originates from a planning image, wherein the planning image is a magnetic resonance imaging (MRI) image acquired under a presence of a main magnetic field having a magnetic field inhomogeneity;
wherein the treatment plan evaluation tool is further configured to receive information about the magnetic field inhomogeneity and wherein the treatment plan evaluation tool is further configured to calculate the quality indicator for the radiotherapy treatment plan by comparing the magnetic field inhomogeneity within an organ with a preset limit for the magnetic field inhomogeneity;
wherein the treatment plan evaluation tool is configured to weight the quality indicator for the radiotherapy treatment plan by organ type, wherein distortions in the planning image caused by the inhomogeneity in the magnetic field get a higher weight when they are at or near a sensitive or critical structure or organ; and
wherein the treatment plan evaluation tool is further configured to weight the quality indicator for the radiotherapy treatment plan by radiation beam orientation.

### Claim 2 (depends on 1)

The treatment plan evaluation tool of claim 1, configured to calculate the quality indicator for the radiotherapy treatment plan using one or more of the following inputs: amount of distortion, prescribed dose, planned dose, tissue sensitivity, distance between organ at risk and tumor, type of organ at risk or tissue represented in the planning image.

### Claim 3 (depends on 1)

The treatment plan evaluation tool of claim 1, configured to compare a geometric distortion caused by the magnetic field inhomogeneity at a location of an organ with a preset limit for the geometric distortion, wherein the treatment plan evaluation tool is configured to provide a warning to a user if the geometric distortion exceeds the preset limit.

### Claim 4 (depends on 1)

The treatment plan evaluation tool of claim 1, configured to display the quality indicator to a user.

### Claim 5 (depends on 1)

The treatment plan evaluation tool of claim 1, configured to use the information about the magnetic field inhomogeneity to geometrically correct the planning image.

### Claim 6 (depends on 1)

The treatment plan evaluation tool of claim 1, comprising a treatment planning unit, configured to generate a radiotherapy treatment plan based on the planning image.

### Claim 7 (depends on 6)

The treatment plan evaluation tool of claim 6, wherein the treatment planning unit is further configured to generate the radiotherapy treatment plan by optimizing the quality indicator.

### Claim 8 (depends on 1)

The treatment plan evaluation tool of claim 1, wherein the treatment plan evaluation tool is further configured to receive the information about the magnetic field homogeneity inhomogeneity from a three dimensional distortion map of at least a portion of an MRI imaging volume from which the planning image is obtained.

### Claim 9 (depends on 8)

The treatment plan evaluation tool of claim 8, wherein the three dimensional distortion map of the MRI imaging volume from which the planning image is obtained is generated from a planar two-dimensional phantom as it passes through the MRI imaging volume.

### Claim 10 (depends on 8)

The treatment plan evaluation tool of claim 8, wherein the three dimensional distortion map of the MRI imaging volume from which the planning image is obtained is a patient-customized map which reflects patient-specific distortions.

### Claim 11

A method, comprising:
determining a magnetic field inhomogeneity of a magnetic resonance imaging system;
acquiring one or more magnetic resonance images with the magnetic resonance imaging system, wherein one or more of the one or more magnetic resonance images result in a planning image;
using the planning image to generate a radiotherapy treatment plan; and
a treatment plan evaluation tool comprising a processor and/or controller using information about the magnetic field inhomogeneity to calculate a quality indicator for the radiotherapy treatment plan by comparing the magnetic field inhomogeneity within an organ with a preset limit, wherein the quality indicator for the radiotherapy treatment plan is weighted by organ type and wherein distortions in the planning image caused by the inhomogeneity in the magnetic field get a higher weight when they are at or near a sensitive or critical structure or organ, wherein the treatment plan evaluation tool is further configured to weight the quality indicator for the radiotherapy treatment plan by radiation beam orientation.

### Claim 12 (depends on 11)

The method of claim 11, wherein a determination of the magnetic field inhomogeneity is used as an input for the calculation of a quality indicator for multiple patients.

### Claim 13 (depends on 12)

The method of claim 12, wherein for each patient the magnetic field inhomogeneity is determined and used as an input for the calculation of the quality indicator.

### Claim 14 (depends on 11)

The method of claim 11, wherein the information about the magnetic field inhomogeneity is used to geometrically correct the one or more magnetic resonance images.

### Claim 15 (depends on 11)

The method of claim 11, wherein the quality indicator is calculated using one or more of the following inputs: amount of distortion, prescribed dose, planned dose, tissue sensitivity of tissue represented in the planning image.

### Claim 16 (depends on 11)

The method of claim 11, wherein the quality indicator is weighted by organ type and wherein distortions in the planning image caused by inhomogeneities in the magnetic field get a higher weight when they are at or near a sensitive or critical structure or organ.

### Claim 17 (depends on 11)

The method of claim 11, wherein the planning image is generated at least partially by optimizing the quality indicator.

### Claim 18 (depends on 11)

The method of claim 11, comprising a step of displaying the quality indicator to a user.

### Claim 19 (depends on 11)

The method of claim 11, wherein determining the magnetic field inhomogeneity of the magnetic resonance imaging system comprises obtaining a three dimensional distortion map of at least a portion of an MRI imaging volume from which the planning image is obtained.

### Claim 20 (depends on 19)

The method of claim 19, wherein obtaining the three dimensional distortion map of at least the portion of the MRI imaging volume from which the planning image is obtained comprises generating the three dimensional distortion map from a planar two-dimensional phantom as it passes through the MRI imaging volume.